Xigduo XR: functions, dosage, side effects, how to use

Function

What is the use of Xigduo XR?

Xigduo extended release tablet (XR) is an oral drug consisting of a combination of two drugs, namely dapagliflozin and metformin. Xigduo XR is a drug used to help control blood sugar in adult patients with type two diabetes. Its use in conjunction with a proper diet and exercise program will help control blood sugar to be more optimal. Xigduo XR is not given as a treatment for type one diabetes patients and those with diabetic ketoacidosis.

Dapagliflozin contained in Xigduo XR works by lowering the rate of glucose re-absorption by the kidneys. Glucose that is not reabsorbed into the bloodstream is excreted along with urine. Meanwhile, metformin which is also one of the ingredients in Xigduo XR works by reducing the amount of glucose produced by the liver and making your intestines absorb less glucose during the digestive process.

What are the rules for using Xigduo XR?

Take Xigduo XR as prescribed by your doctor. Take this medicine once in the morning at the same time as food. Swallow this medication whole, do not crush, split, or chew this tablet. Doing so will increase the risk of side effects.

Your doctor will probably give you a low dose at the start of treatment and will increase it gradually. Dosage is given taking into account your health condition and your body's response to treatment. Do not change your dose without discussing it with your doctor.

Take this drug regularly to get its benefits. To make it easier for you to remember to drink it at the same time every day.

What are the rules for storing Xigduo XR?

This medication is best stored at room temperature away from direct light. Do not store this medication in a damp place, such as a bathroom. Keep out of reach of children and pets.

Do not flush this medication down the toilet or flush it down the drain unless instructed to do so. Discard this product if it has reached its expiration date or is no longer used. Consult your pharmacist or local waste disposal company regarding the proper way to dispose of this product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Xigduo XR for adult patients?

The administration of Xigduo XR was based on each individual's response to treatment. The following is the dosage reference for adult patients with type two diabetes:

• Initial dose for patients who have not taken dapagliflozin: 5 mg, once daily
• Initial dose for patients who have not taken metformin extended release : 2,000 mg
• For patients who need 5 mg dapagliflozin and 2,000 mg metformin extended release , use two Xigduo XR tablets in a dosage of 2.5 mg dapagliflozin / 1,000 mg metformin extended release
• Maximum daily dose: dapagliflozin 10 mg / metformin extended release 2,000 mg (can use two Xigduo XR tablets in a dosage of 5 mg / 1,000 mg, once a day)

Patients taking metformin extended release at night, you should skip the dose that night before starting treatment with Xigduo XR in the morning.

In what dosage and dosage is Xigduo XR (dapagliflozin-metformin HCl XR) available?

Tablets (extended release), Oral: 2.5 mg / 1,000 mg; 5 mg / 500 mg; 5 mg / 1,000 mg; 10 mg / 500 mg.

Side effects

What side effects may occur due to consumption of Xigduo XR?

Using too much metformin can sometimes cause lactic acidosis in certain people. It is characterized by unusual fatigue, dizziness, intense drowsiness, muscle pain, difficulty breathing, irregular heartbeat, or stomach pain accompanied by nausea and vomiting. Contact your doctor immediately if you notice these symptoms.

Tell your doctor if you notice any of the following symptoms of side effects:

• Urinating less urine
• Dehydration, characterized by weakness, dizziness, feeling like falling
• Symptoms of a urinary tract infection characterized by pain or a burning sensation when urinating, frequent urination, bloody urine, fever, pain in the pelvis or waist
• Symptoms of a genital infection, such as pain, burning, itching, rash, redness, odor, or excretion of fluid from the penis or vagina
• Runny or stuffy nose, sore throat

Serious allergic reactions are known to rarely occur as a result of using this drug. Even so, stop treatment and contact your doctor if you get signs of a drug allergic reaction, such as itching, redness, swelling of the face, eyes, lips, tongue and throat, and difficulty breathing.

The list above does not cover all possible side effects that may occur. Talk to your doctor about the possible side effects that you are worried about.

Warnings and Precautions

What should I know before taking Xigduo XR?

• Tell your doctor if you have an allergy to dapagliflozin (Farxiga) or metformin and all other medicines
• Tell your doctor about any medical history you have, including any diseases you have or are currently having, especially if you have kidney disease, low blood pressure, urinary tract infections, urinary tract cancer, problems with your heart or pancreas, and if you have any symptoms. a low-salt diet
• Some people who take dapagliflozin develop urinary tract cancer, but no research has proven that this drug is the main cause.
• You may need to stop Xigduo XR treatment if you plan to have an X-ray procedure using contrast fluid. Inform your doctor about the use of this drug before doing a CT scan / MRI
• Tell your doctor if you are planning or are pregnant. Dapagliflozin can pose a risk to the fetus if it is taken in the second or third trimester
• Metformin can stimulate ovulation in premenopausal women and increase the chances of having an unplanned pregnancy. Talk to your doctor about using the best birth control device while using this medicine
• Xigduo XR is not for those younger than 18 years

Is Xigduo XR safe for pregnant and lactating women?

By the US Food and Drug Administration, the FDA, Xigduo XR falls into category D (there is positive evidence of risk). For this reason, the use of Xigduo XR must be stopped as soon as pregnancy is detected. Likewise for nursing mothers, it is not recommended to give breast milk to their child while taking this medicine.

Drug Interactions

What medicines may interact with Xigduo XR?

The following is a list of drugs that may interact with Xigduo XR (dapagliflozin-metformin XR), namely:

• Digoxin (digitalis, Lanoxin)
• Diuretic
• Insulin or other diabetes medication
• Rifampin
• Ritonavir
• NSAID class drugs, such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, and meloxicam
• Medicines for seizures, such as phenobarbital and phenytoin

The above list may not include all of the drugs that interact with Xigduo XR. Keep a list of all medications you have or are currently taking and inform your doctor before taking Xigduo XR, including prescription, non-prescription, vitamin, or herbal medicines.

Certain drugs that are taken at the same time may cause drug interactions, and may prevent the drug from working optimally or increase the risk of side effects. Even so, sometimes doctors prescribe two drugs that may interact simultaneously if deemed necessary by adjusting the dose.

Overdose

What should I do if I overdose on Xigduo XR?

Call emergency medical help right away (119) or the nearest hospital emergency department if you have overdosed on Xigduo XR. Symptoms of a Xigduo XR overdose are fainting and difficulty breathing. An overdose of this drug can also cause lactic acidosis, which is characterized by nausea / vomiting / diarrhea, rapid breathing, and an irregular heartbeat.

What should I do if I miss my medication schedule?

If you forget your scheduled medication, take it as soon as you remember. If the distance is too close, ignore the missed schedule and continue with your regular dose. Do not double your dose on a single medication schedule.