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Norfloxacin: functions, dosage, side effects, how to use it

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What drug Norfloxacin?

What is norfloxacin for?

Norfloxacin is a drug used to treat various bacterial infections. This drug belongs to a class of drugs called quinolone antibiotics. It works by stopping bacterial growth.

This antibiotic only treats bacterial infections. Medicines will not work for viral infections (eg, cold, flu). unnecessary or excessive use of any antibiotic can cause its effectiveness to decrease.

How to use norfloxacin?

Take this medication by mouth, usually twice daily, at least 1 hour before or 2 hours after meals or with dairy products (eg, milk, yogurt). Drink with a full glass of water (8 ounces or 240 milliliters). Dosage is based on your medical condition and response to treatment. Drink plenty of fluids while using this medicine unless your doctor directs you otherwise.

Take this medication at least 2 hours before or 2 hours after taking medications containing magnesium, aluminum, or calcium. Some examples include quinapril, certain forms of ddI (chewable / dispersed tablets or ready-to-drink solutions for children), vitamins / minerals, and antacids. Follow the same directions if you are consuming juices fortified with calcium, subsalicylate, sucralfate, iron, and zinc. Drugs / products that bind to norfloxacin and prevent full absorption.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. It is important not to miss a dose. You need to remember to take this medication at the same time every day.

Continue to take this medication until the prescribed amount is finished, even if symptoms disappear after a few days. Stopping treatment too early allows bacteria to continue growing, which can result in a return of infection.

Tell your doctor if your condition persists or gets worse.

How is norfloxacin stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Norfloxacin dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of norfloxacin for adults?

Normal dosage for adults with urinary tract infections:

Without complications:

Caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis: 400 mg taken every 12 hours for 3 days

Caused by other organisms: 400 mg taken every 12 hours for 7 to 10 days

Complicated: 400 mg orally every 12 hours for 10 to 21 days

Normal Dosage for Adults with Cystitis:

Caused by E coli, K pneumoniae, or P mirabilis: 400 mg taken every 12 hours for 3 days

Due to other organisms: 400 mg taken every 12 hours for 7 to 10 days

Normal dosage for adults with prostatitis:

Acute or chronic: 400 mg taken every 12 hours for 28 days

Normal Dosage for Adults with Gonococcal Infection

With complications: 800 mg taken at one time

7 days of doxycycline therapy (if not pregnant) or a single dose of azithromycin are also recommended for possible coexisting infections with chlamydia.

Normal Dosage for Adults with Campylobacter Gastroenteritis:

400 mg taken every 12 hours for 3 days

Immunocompromised patients may require 7 to 14 days of therapy.

Normal Dosage for Adults with Epididymitis - Non-Specific:

Not sexually transmitted: 400 mg taken every 12 hours for 14 days

Normal Dosage for Adults with Pyelonephritis:

Mild infections: 400 mg diminu every 12 hours for 14 days

Normal Dose for Adults with Enteric Salmonella Fever:

400 mg taken every 12 hours for 7 to 14 days

Normal Dose for Adults with Salmonella Gastroenteritis:

400 mg taken every 12 hours for 5 days. However, most cases of self-limiting and ending antibiotic therapy do not mean to slow recovery.

Immunocompromised patients may require 14 days of therapy.

Adult Dose for Shigellosis:

400 mg taken every 12 hours for 5 days

Immunocompromised patients may require 7 to 10 days of therapy.

Normal dosage for adults with diarrhea:

400 mg taken every 12 hours for 3 days. However, most cases of self-limiting and ending antibiotic therapy do not appear to slow recovery.

Immunocompromised patients may require 7 to 14 days of therapy.

What is the dosage of norfloxacin for children?

The dosage for children has not been determined. Consult your doctor for more information.

In what dosage is norfloxacin available?

Tablets, taken by mouth: 400 mg

Norfloxacin side effects

What side effects can be experienced due to norfloxacin?

Get emergency medical help if you have any of the following signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking norfloxacin and call your doctor right away if you have sudden pain, snapping or a voice, bruising, swelling, pain, stiffness, or loss of motion in any of your joints. Rest until you receive further medical or instructional care.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody
  • headache with chest pain and severe dizziness, fainting, fast or pounding
  • irregular heart rhythm, new or worsening cough, difficulty breathing
  • hallucinations, tremors, feeling restless or anxious, unusual thoughts or behavior, seizures (seizures)
  • ringing in the ears, vision problems, pain behind your eyes
  • confusion, nausea and vomiting, swelling, rapid weight gain, urinating less than usual or not at all
  • numbness, burning sensation, pain, or tingling in the hands or feet
  • pain in the upper abdomen, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • pale skin, easy bruising or bleeding, muscle weakness, fever, glands, swollen glands, general feeling of pain
  • the first sign of any skin rash, no matter how mild
  • severe skin reactions - fever, sore throat, swelling in your face or tongue, burning sensation in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially on the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea or diarrhea, stomach cramps, heartburn
  • anal pain
  • headache, dizziness
  • sweating
  • back pain
  • vaginal itching or discharge

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Norfloxacin Drug Warnings and Cautions

What should be known before using norfloxacin?

Before using norfloxacin, tell your doctor and pharmacist if you are allergic or have a severe reaction to norfloxacin / other quinolones or fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available in the US), gemifloxacin (factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin) (not available in the US), moxifloxacin (Avelox), nalidixic acid (NegGram), ofloxacin (Floxin), and Sparfloxacin (Zagam) (not available in the US), or other drugs.

Tell your doctor and pharmacist what prescription and non-prescription drugs, vitamins, herbal products, and nutritional supplements you are taking or plan to take. Be sure to mention these medications such as: other antibiotics; anticoagulants (“blood thinners”) such as warfarin (Coumadin, Jantoven); certain antidepressants; antipsychotics (drugs to treat mental illness); caffeine or drugs containing caffeine (Excedrin, NoDoz, Vivarin, others); cisapride (Propulsid) (not available in the US); clozapine (Clozaril, FazaClo); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'); erythromycin (E.E.S, E-Mycin, Erythrocin, etc.); glyburide (DiaBeta, in Glucovance, Micronase, others); certain medications for irregular heartbeats such as amiodarone (Cordarone), procainamide (Procanbid), quinidine, and sotalol (Betapace, Betapace AF, Sorine); nitrofurantoin (Furadantin, Macrobid, Macrodantin); probenecid (in Col-Probenecid, Probalan); nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Naprosyn, others); ropinirol (Requip); tacrine (Cognex); theophylline (Elixophyllin, Theo-24, Uniphyl, others); and Tizanidine (Zanaflex). Your doctor may need to change the dose of your medication or monitor you carefully for side effects.

If you are taking antacids that contain aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), ddI (Videx) sucralfate (Carafate), or supplements or multivitamins that contain iron or zinc, take this medication 2 hours before or 2 hours after you take norfloxacin.

Tell your doctor if you or someone in your family have or have had a prolonged QT interval (a rare heart problem that can cause irregular heartbeats, fainting or sudden death) or irregular heartbeats and if you have or have ever had nerve problems., low levels of potassium in your blood, slow heart rate, chest pain, seizures, myasthenia gravis (a condition that causes certain muscle weakness), cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can cause a stroke or mini-stroke), or glucose -6-phosphate dehydrogenase (G-6PD) deficiency (an inherited blood disorder).

Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. If you become pregnant while on norfloxacin treatment, call your doctor.

You should know that this drug can cause dizziness, lightheadedness, and fatigue. Don't drive a car, operate machinery, or participate in activities that require alertness and coordination until you know how norfloxacin affects you.

Plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet rays (tanning tables and sun lamps), and wear protective clothing, sunglasses, and sunscreen. Norfloxacin can make your skin sensitive to sunlight or ultraviolet rays. If your skin becomes red, swollen, or blistered, call your doctor.

Is norfloxacin safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

  • A = No risk,
  • B = not at risk in several studies,
  • C = May be risky,
  • D = There is positive evidence of risk,
  • X = Contraindicated,
  • N = Unknown

There are not sufficient studies in women to find out the risk to the baby when the mother takes this drug during breastfeeding. Consider the potential benefits and potential risks before taking this medication during breastfeeding.

Drug Interactions of Norfloxacin

What medicines may interact with norfloxacin?

Drug interactions can change how your medications work or increase your risk of serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription / nonprescription drugs and herbal products) and tell your doctor and pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

  • antiarrhythmics (eg, amiodarone, Disopyramide, dofetilide, quinidine, sotalol), cisapride, diuretics (eg, furosemide, hydrochlorothiazide), macrolide or ketolide antibiotics (eg, erythromycin, telithromycin), drugs for mental or mood disorders, medicines that can affect your heart rate, phenothiazines (for example, chlorpromazine), or tricyclic antidepressants (for example, amitriptyline) because of the risk of serious side effects, including irregular heartbeats and other heart problems, can increase. Check with your doctor or pharmacist if you are not sure if your medicine can affect your heart rate
  • non-steroidal anti-inflammatory drugs (NSAIDs) (eg ibuprofen) because the risk of side effects, such as seizures, may increase
  • corticosteroids (eg prednisone) because of the increased risk of tendon damage
  • probenecid because it can increase the risk of norfloxacin side effects
  • nitrofurantoin because it can decrease the effectiveness of norfloxacin
  • anti-clotting (eg, warfarin), caffeine, clozapine, cyclosporine, methotrexate, ropinirol, serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, venlafaxine), sulfonylureas (eg, glyburide), tacrine, theophyllines, or tizanidine due to their risk of side effects can be increased with norfloxacin
  • live vaccines or mycophenolate because of their effectiveness may be decreased by norfloxacin

Can food or alcohol interact with norfloxacin?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider. For this medication, use caution with dairy-based foods.

What health conditions can interact with norfloxacin?

The presence of other medical problems may affect the use of this drug. Make sure you tell your doctor if you have any other medical problems, especially:

  • bradycardia (slow heart rate)
  • diabetes
  • diarrhea
  • heart disease
  • heart rhythm problems (for example, long QT interval), or family history
  • hypokalemia (low potassium in the blood), uncorrected
  • liver disease (including hepatitis)
  • myocardial ischemia (reduced blood supply to the heart)
  • seizures (epilepsy), or a history of epilepsy - use with caution. It might make things worse
  • brain disease (for example, hardening of the arteries)
  • Kidney illness
  • organ transplant (eg, heart, kidney, or lung), history of organ transplantation
  • gout disorders (eg, rheumatoid arthritis), history of gout - use with caution. May cause side effects to be worse
  • G6PD deficiency (enzyme problem) - anemia may occur while using this medicine
  • myasthenia gravis (severe muscle weakness), or a history of the disease
  • tendinitis (inflammation of the tendons), its history
  • tendon rupture, case history, should not be used in patients with this condition.

Norfloxacin overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Norfloxacin: functions, dosage, side effects, how to use it
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