Piperacillin + tazobactam: functions, dosage, side effects, how to use

Piperacillin + Tazobactam What Drugs?

What is piperacillin + tazobactam for?

Piperacillin and Tazobactam are penicillin antibiotics that fight bacteria in the body.

Piperacillin and Tazobactam are a combination drug used to treat a variety of different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.

This medicine is sometimes given at the same time as other antibiotics.

Piperacillin and Tazobactam can also be used for purposes not listed in the medication guide.

How do I use piperacillin + tazobactam?

Piperacillin and Tazobactam are injected into a vein through an IV. You may be told how to use the IV at home. Do not inject this medicine yourself if you do not know how to administer the injection and correctly regulate the needles used, IV tubes, and other items used to inject the medicine.

Piperacillin and Tazobactam are usually given for 7 to 10 days, depending on the infection being treated. Follow all directions on your prescription label. Do not use this medication in amounts greater or less or for longer than recommended.

Piperacillin and Tazobactam must be mixed with a liquid (diluent) before using them. If you are using the injection at home, make sure you understand how to properly mix and store the medication.

Prepare the dose only when you are ready to give the injection. Do not use this medication if the medicine has changed color or has particles in it. Contact your pharmacist for new drugs.

If you are using this medicine long-term you may need frequent medical tests from your doctor.

Use the syringe for one-time use only, then dispose of it in a special puncture container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of reach of children and pets.

Use this medication for the length as prescribed. Your symptoms may improve before the infection is completely cleared. Skipping doses can also increase the risk of further infection that is resistant to antibiotics. Piperacillin and Tazobactam will not treat viral infections such as the common cold or flu.

This medication may cause unusual results on certain medical tests. Tell the doctor who treats you that you are taking Piperacillin and tazobactam.

Store unmixed medications with liquid diluents at cool room temperature.

The medicine that is already mixed in the infusion bag should be used within 24 hours if you store it at room temperature.

The drug mixture in the infusion pump should be used within 12 hours if you store it at room temperature.

The mixed medicine in an infusion bag can also be stored in the refrigerator for up to 7 days. Don't freeze it. Throw away any unused mixture that hasn't been used at that time.

How to store piperacillin + tazobactam?

This medication is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines out of reach of children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Piperacillin + Tazobactam dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of piperacillin + tazobactam for adults?

Usual Adult Dose for Intraabdominal Infection:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for 7 to 10 days, depending on the nature and severity of the infection; Once the patient is stable and able to tolerate oral drugs, oral antibiotic therapy can be changed according to microbiological sensitivity data.

In severe infections, piperacillin levels immediately withdrawn before the 4th or 5th dose may be helpful. Serum piperacillin levels greater than 16 mcg / mL may be associated with increased effectiveness.

Usual Adult Dose for Peritonitis:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for 7 to 10 days, depending on the nature and severity of the infection.

Usual Adult Dose for skin or soft tissue infections:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Endometritis:

3.375 g infusion every 6 hours; 4.5 g IV infusion every 8 hours has also been used.

Duration: Parenteral therapy should be continued for at least 24 hours after the patient remains feverish, pain free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if chlamydial infection is also present in the late postpartum patient (breastfeeding should be stopped).

Usual Adult Dose for Pelvic Inflammatory Disease:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for 7 to 10 days, depending on the nature and severity of the infection
If the patient is not pregnant, 14 days of oral doxycycline therapy should be considered to treat a possible chlamydial infection at the same time. The patient's partner should also be examined.

Usual Adult Dose for Lung Inflammation:

Those with pneumonia (moderate level): 3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used

Duration: for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Nosocomial Lung Inflammation:

Moderate to severe: 4.5 g infusion every 6 hours.

Duration: for 7 to 14 days, depending on the nature and severity of the infection.

Initial empiric treatment with broad spectrum coverage according to antibiogram and / or hospital emergency room is highly recommended if resistant organisms have been identified.

If the causative organism is not pseudomonas aeruginosa, the duration of treatment should be as short as possible (eg, only 7 days) to reduce the risk of superinfection with resistant organisms.

Usual Adult Dose for Aspiration of Pneumonia:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: Parenteral therapy should be continued until the patient's clinical condition is stable and the fever has subsided. Oral antibiotic therapy may be changed later according to microbiological sensitivity data. Treatment of documented anaerobic pleuropulmonary infections should be continued until the oozing has cleared, or a residual scar forms, sometimes for 2 to 4 months.

Usual Adult Dose for Bacteremia:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for about 14 days, depending on the nature and severity of the infection; Once the patient is stable and able to tolerate oral drugs, oral antibiotic therapy can be changed according to microbiological sensitivity data.

In severe infections, even piperacillin levels (withdrawn immediately before the 4th or 5th dose) may help. Serum piperacillin levels exceeding 16 mcg / mL may increase effectiveness.

Usual Adult Dose for Deep Neck Infection:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for about 2 to 3 weeks, depending on the nature and severity of the infection; Once the patient is stable and able to tolerate oral drugs, oral antibiotic therapy can be changed according to microbiological sensitivity data.

Usual Adult Dose for Neutropenia fever:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: Therapy should be continued for about 14 days, or until more specific therapy can be changed for proven infection, or until the patient has no fever for 24 hours after the absolute neutrophil count is greater than 500 / mm3. The total duration of therapy depends on the nature and severity of the infection. Once the patient is stable and able to tolerate oral drugs, oral antibiotic therapy can be changed according to microbiological sensitivity data.

In severe infections, even piperacillin levels (withdrawn immediately before the 4th or 5th dose may be helpful. Serum piperacillin levels greater than 16 mcg / ml may increase effectiveness.

Usual Adult Dose for Joint Infection:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: Therapy should be continued for about 3 to 4 weeks, depending on the nature and severity of the infection. Longer therapy, 6 weeks or more, may be needed for prosthetic joint infections. In addition, it is usually necessary to clean the prosthesis involved.

Usual Adult Dose for Osteomyelitis:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: Therapy should be continued for about 4 to 6 weeks, depending on the nature and severity of the infection. Chronic osteomyelitis may require additional oral antibiotic therapy, possibly for up to 6 months. Surgical debridement of the devitalized bone is essential for the management of osteomyelitis.

Usual Adult Dose for Pyelonephritis:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for about 14 days, depending on the nature and severity of the infection; Once the patient is stable and able to tolerate oral drugs, oral antibiotic therapy can be changed according to microbiological sensitivity data.

Usual Adult Dose for Urinary Tract Infection:

3.375 g infusion every 6 hours; 4.5 g infusion every 8 hours has also been used.

Duration: for approximately 7 to 10 days, depending on the nature and severity of the infection; Once the patient is stable and able to tolerate oral drugs, oral antibiotic therapy can be changed according to microbiological sensitivity data.

What is the dosage of piperacillin + tazobactam for children?

Usual Children's Dose for Peritonitis:
2 to 9 months: 80 mg / kg (piperacillin component) infusion every 8 hours
9 months or more:
40 kg or less: 100 mg / kg (piperacillin component) infusion every 8 hours
Greater than 40 kg: 3.375 g infusion every 6 hours

Usual Children's Dose for Appendicitis:
2 to 9 months: 80 mg / kg (piperacillin component) infusion every 8 hours
9 months or more:
40 kg or less: 100 mg / kg (piperacillin component) infusion every 8 hours
Greater than 40 kg: 3.375 g infusion every 6 hours

Piperacillin + Tazobactam side effects

What side effects can be experienced due to piperacillin + tazobactam?

Seek immediate medical help if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Call your doctor if you have serious side effects such as:

• diarrhea that is watery or bloody

• pale or yellowed skin, dark colored urine, fever, confusion or weakness

• feeling of dizziness or shortness of breath, fast heart rate, difficulty concentrating

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red spots under your skin;

• dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heartbeat, feeling dizzy, fainting;

• fever, chills, body aches, flu symptoms

• white patches or sores inside your mouth or lips or
  convulsions

Milder side effects may include:

• nausea, vomiting, stomach pain or irritability

• constipation, mild diarrhea

• headache, dizziness, agitation

• cold

• anxiety, sleep problems (insomnia)

• skin rash or hives

• pain, swelling, or other irritation at the injection site or

• itching or discharge in the vagina

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Warnings and Cautions Piperacillin + Tazobactam

What should be known before using piperacillin + tazobactam?

Before using a particular medication, weigh the risks and benefits first, which is a decision you and your doctor should make. For this drug, pay attention to the following:

Tell your doctor if you have any unusual or allergic reactions to this or any other medicine. Also tell your doctor if you have any other types of allergies such as to food, coloring, preservatives, or animal allergies. For over-the-counter products, read the labels on the packaging carefully.

Sufficient research to date has not demonstrated the problems related to children that would limit the use of the Piperacillin and Tazobactam combination in children. However, the safety and efficacy of this drug have not been determined for children younger than 2 months of age.

Sufficient research to date has not demonstrated specific geriatric problems that will limit the usefulness of Piperacillin and the Tazobactam combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require adjusting the dose for patients receiving the combination Piperacillin and Tazobactam.

Is piperacillin + tazobactam safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Breastfeeding

Studies in women have shown that this drug poses only a slight risk to the baby when used during breastfeeding.

Drug Interaction Piperacillin + Tazobactam

What medicines may interact with piperacillin + tazobactam?

It is not recommended to use this medicine with any of the following medicines. Your doctor may decide not to give you this drug or change some of the other drugs you are taking.

• Acrivastine
• Bupropion
• Chlortetracycline
• Demeclocycline
• Doxycycline
• Lymecycline
• Meclocycline
• Methacycline
• Methotrexate
• Minocycline
• Oxytetracycline
• Rolitetracycline
• Tetracycline
• Vecuronium
• Warfarin

Can food or alcohol interact with piperacillin + tazobactam?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with piperacillin + tazobactam?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• bleeding problems
• congestive heart failure
• diarrhea
• heart disease
• hypokalemia (low potassium in the blood)
• kidney failure - use with caution. It might make your condition worse
• cystic fibrosis (genetic disorder) - The risk for fever and skin rash in patients with this condition may increase
• kidney disease - use with caution. Side effects may increase as the cleansing of the drug in the body slows down

Piperacillin + Tazobactam overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.