Diplunisal: function, dosage, side effects, how to use it

What is the drug?

What is it for?

Diplunisal is used to relieve mild to moderate pain from a variety of conditions. This medication is also used to reduce pain, swelling, and joint stiffness caused by arthritis. Reducing these symptoms helps you to carry out your normal daily activities. These drugs are known as nonsteroidal anti-inflammatory drugs (NSAIDs).

OTHER USES: This section lists uses for this drug that are not listed on approved labels, but may be prescribed by your healthcare professional. Use this medication for the conditions listed below only if it has been prescribed by your doctor and health care professional.

This drug can also be used to treat gout attacks.

How to use diflunisal?

Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this medicine. Take this medication with food / milk or right after meals to prevent stomach upset.

Late this drug entirely. Do not crush or chew the tablet. Doing so can increase side effects.

Dosage is based on your medical condition and response to treatment. Don't take more than 1,500 milligrams per day. To minimize the risk of side effects (for example, stomach bleeding), use this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take it more often than prescribed. For ongoing conditions such as arthritis, continue to use as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

In certain conditions (for example, arthritis), it may take up to 2 weeks of regular use before the full benefits of this medication are felt.

If you are taking these medications as needed (not on a regular schedule), remember that pain medications work best if they are used when signs of illness first appear. If you wait until the pain has worsened significantly, the medication may not work very well.

Tell your doctor if your condition worsens.

How is storage diflunisal?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Diflunisal dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of diflunisal for adults?

Normal Adult Dosage for Pain Relief

Initial dose: 1000 mg taken one time.

Treatment: 500 mg taken every 12 hours. Some patients may need 500 mg every 8 hours.

Normal dosage for adults with osteoarthritis

250 to 500 mg taken by mouth twice daily.

The dose can be increased or decreased according to the patient's response. Maintenance doses higher than 1500 mg / day are not recommended.

Normal Dosage for Adults with Rheumatoid Arthritis

250 to 500 mg taken by mouth twice daily.

The dose can be increased or decreased according to the patient's response. Maintenance doses higher than 1500 mg / day are not recommended.

What is the dose of diflunisal for children?

There is no provision for the dosage of this drug for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is diflunisal available?

Tablet, oral:

Generic: 500 mg

Diflunisal side effects

What side effects can be experienced due to diflunisal?

Some of the serious side effects include but are not limited to fatal bleeding from the stomach, chest pain, stroke and shortness of breath.

Get emergency medical help if you have any of the following signs of an allergic reaction: hives; hard to breath; swelling of your face, lips, tongue, or throat.

Stop using diflunisal and call your doctor at once if you have any of the serious side effects such as:

• chest pain, slurred speech, problems with vision or balance, and feeling weak or short of breath
• bloody stools, coughing up blood or vomiting that looks like coffee grounds
• fever, chills, body aches, flu symptoms
• pale or yellowing skin, dark colored urine, confusion
• swelling or rapid weight gain
• urinating less than usual or not at all
• nausea, upper abdominal pain, hives, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• skin rash, bruising, severe tingling, numbness, pain, muscle weakness
• fever, sore throat, and headache with severe blistering, peeling, and reddish skin rash
• the first sign of any skin rash, no matter how mild.

Less serious side effects may include:

• mild nausea, stomach pain, vomiting,
• diarrhea, constipation, passing wind
• dizziness, drowsiness, headache, tired feeling
• sleep problems (insomnia)
• ringing in your ears.

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Warning and Caution of Diplunisal Drugs

What should be known before using diflunisal?

Before using diflunisal, tell your doctor and pharmacist if you are allergic to diflunisal, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), or any other medications.

Tell your doctor and pharmacist what prescription and non-prescription drugs, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to name the drug listed in the IMPORTANT WARNING section and one of the following drugs: acetaminophen (Tylenol); enzyme (ACE) angiotensin-converting inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and Trandolapril (Mavik); angiotensin II receptor antagonists such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan); antacids; cyclosporine (Neoral, Sandimmune); diuretics ('water pills'); indomethacin (Indocin); lithium (Eskalith, Lithobid); methotrexate (Rheumatrex); and sulindac (Clinoril). Your doctor may need to change the dose of your medication or watch you carefully for side effects.

Tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING or asthma sections, especially if you also have a runny nose or nasal polyps (swelling of the nasal passages); swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease.

Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you are planning pregnancy, or you are breastfeeding. If you become pregnant while taking diflunisal, contact your doctor.

If you are having surgery, including dental surgery, tell your doctor or dentist that we are using diflunisal.
Call your doctor if you think you may have a virus, such as chicken pox or the flu. Do not take diflunisal if you have a virus, and do not give diflunisal to a child who has the virus.

Is diflunisal safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

There are not sufficient studies in women to find out the risk to the baby when the mother takes this drug during breastfeeding. Consider the potential benefits and potential risks before taking this medication during breastfeeding.

Diflunisal Drug Interactions

What medicines may interact with diflunisal?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Taking this drug with any of the following medicines is not recommended. Your doctor may not prescribe this drug to you or will replace some of the drugs you are already taking.

• Ketorolac

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Abciximab
• Anagrelide
• Apixaban
• Ardeparin
• Argatroban
• Beta Glucan
• Bivalirudin
• Certoparin
• Cilostazol
• Citalopram
• Clopidogrel
• Clovoxamine
• Cyclosporine
• Dabigatran Etexilate
• Dalteparin
• Danaparoid
• Desirudin
• Dipyridamole
• Duloxetine
• Enoxaparin
• Eptifibatide
• Erlotinib
• Escitalopram
• Femoxetine
• Feverfew
• Flesinoxan
• Fluoxetine
• Fondaparinux
• Ginkgo
• Gossypol
• Heparin
• Lepirudin
• Levomilnacipran
• Meadowsweet
• Methotrexate
• Milnacipran
• Nadroparin
• Nefazodone
• Parnaparin
• Paroxetine
• Pemetrexed
• Pentosan Polysulfate Sodium
• Pentoxifylline
• Phenprocoumon
• Pralatrexate
• Prasugrel
• Protein C
• Reviparin
• Rivaroxaban
• Sibutramine
• Tacrolimus
• Ticlopidine
• Tinzaparin
• Tirofiban
• Venlafaxine
• Vilazodone
• Vortioxetine
• Zimeldine

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Acebutolol
• Acenocoumarol
• Acetohexamide
• Alacepril
• Alprenolol
• Amiloride
• Amlodipine
• Anisindione
• Arotinolol
• Atenolol
• Azilsartan Medoxomil
• Azosemide
• Befunolol
• Bemetizide
• Benazepril
• Cyclopenthiazide
• Benzthiazide
• Bepridil
• Betaxolol
• Bevantolol
• Bisoprolol
• Bopindolol
• Bucindolol
• Bumetanide
• Bupranolol
• Buthiazide
• Candesartan Cilexetil
• Canrenoate
• Captopril
• Carteolol
• Carvedilol
• Celiprolol
• Chlorothiazide
• Chlorpropamide
• Chlorthalidone
• Cilazapril
• Clopamide
• Cyclopenthiazide
• Delapril
• Desvenlafaxine
• Dicumarol
• Dilevalol
• Diltiazem
• Enalaprilat
• Enalapril Maleate
• Eprosartan
• Esmolol
• Ethacrynic Acid
• Felodipine
• Flunarizine
• Fosinopril
• Furosemide
• Gallopamil
• Gliclazide
• Glimepiride
• Glipizide
• Gliquidone
• Glyburide
• Hydrochlorothiazide
• Hydroflumethiazide
• Imidapril
• Indapamide
• Irbesartan
• Isradipine
• Labetalol
• Lacidipine
• Landiolol
• Levobunolol
• Lidoflazine
• Lisinopril
• Losartan
• Manidipine
• Mepindolol
• Methyclothiazide
• Metipranolol
• Metolazone
• Metoprolol
• Moexipril
• Nadolol
• Nebivolol
• Nicardipine
• Nifedipine
• Nilvadipine
• Nimodipine
• Nipradilol
• Nisoldipine
• Nitrendipine
• Olmesartan Medoxomil
• Oxprenolol
• Penbutolol
• Pentopril
• Perindopril
• Pindolol
• Piretanide
• Polythiazide
• Pranidipine
• Propranolol
• Quinapril
• Ramipril
• Sotalol
• Spirapril
• Spironolactone
• Talinolol
• Tasosartan
• Telmisartan
• Temocapril
• Tertatolol
• Timolol
• Tolazamide
• Tolbutamide
• Torsemide
• Trandolapril
• Triamterene
• Trichlormethiazide
• Valsartan
• Verapamil
• Warfarin
• Xipamide
• Zofenopril

Can food or alcohol interact with diflunisal?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with diflunisal?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• anemia
• asthma
• bleeding problems
• blood clots
• edema (fluid retention or body swelling)
• heart attack, history
• heart disease (for example, congestive heart failure)
• high blood pressure
• Kidney illness
• liver disease (for example, hepatitis)
• stomach pain or intestinal ulcers or bleeding
• history of stroke - use with caution. This medicine can make the condition worse.
• a history of aspirin sensitivity - this drug should not be used in patients with this condition
• heart surgery - this drug is not recommended for pain relief right before or after surgery.

Diplunisal overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Overdose symptoms may include:

• sleepy
• gag
• stomach ache
• diarrhea
• decreased frequency of urination
• quick breath
• fast heart rate
• sweating
• ringing in the ears
• confusion
• coma (loss of consciousness for a period of time)

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.