Domperidone: functions, dosage, side effects, how to use it

Function

What is domperidone for?

Domperidone is a drug that aims to increase the movement or contraction of the stomach and intestines. Domperidone is a drug that you can use to treat nausea and vomiting caused by other drugs. Domperidone is a drug that is often used to treat symptoms of Parkinson's disease.

Parkinson's is a progressive disorder of the nervous system, and affects the person's ability to move. This disease begins with a small tremor in the hand, or usually a muscle feeling stiff, and gets worse over time.

Usage and Storage

How do I use domperidone?

You can take this drug by following the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

Domperidone drugs are drugs that are taken orally and rectally (through the anus). Take the medicine 15-30 minutes before meals and before you go to sleep if needed. Do not crush or chew the medicine.

How do I store domperidone?

Domperidone is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules.

Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed.

Consult your pharmacist or local waste disposal agency about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the domperidone dosage for adults?

The following is the recommended domperidone dosage for adults:

Nausea and vomiting

The dose of domperidone that can be taken by mouth for nausea and vomiting is 10-20 mg every 4-8 hours. The maximum amount of domperidone is 80 mg / day.

For domperidone taken rectally or anus, the dose is 60 mg 2 times a day.

Non-ulcer dyspepsia

The dose of domperidone that can be taken for non-ulcer dyspepsia is 10-20 mg 3 times a day and at night.

Migraine

The dose of domperidone that can be taken for migraines is as much
20 mg every 4 hours, and combined with paracetamol as needed. Maximum of 4 doses in 24 hours.

What is the domperidone dosage for children?

Domperidone doses that can be taken for nausea and vomiting in children are as follows:

Children 2 years and over and weighing more than 35 kg, can take 10-20 mg doses 3-4 times a day. Maximum dose is 80 mg daily.

Meanwhile, for use through the rectum or anus, use this drug as much as 60 mg 2 times a day.

Important to note. Every child has a different weight even though they are the same age. Children who are overweight, on average, need more than the recommended dosage on the domperidone drug packaging label. This does have an effect on the effectiveness of the drug. Likewise, if the child is underweight.

However, you need to note that if you want to overdo the dose, consult your doctor first. In essence, mistakes in taking medication in children can be avoided if you first ask a doctor or pharmacist for advice and comply with the drinking rules.

In what preparations is this drug available?

Domperidone is available in the form of a 10 mg tablet, as well as a suppository capsule to be inserted through the rectum or anus with a size of 30 mg.

Side effects

What are the possible side effects of domperidone?

Some of the side effects of domperidone can just happen without the need for serious medical treatment. These side effects may disappear as you treat Parkinson's disease, and as your body adjusts to the medication. Later, your doctor can tell you about ways to prevent or reduce some of these side effects.

Check with your doctor if you experience any of the following side effects that are persistent or bothersome or if you have any further questions:

The side effects of domperidone that are quite common are:

• Milk comes out of the nipple
• dry mouth
• breast enlargement in men
• headache
• itchy rash
• heatstroke
• itchy skin
• itchy, red, painful, or swollen eyes
• irregular menstruation
• breast pain

Side effects of domperidone are quite rare:

• frequent urination
• change in appetite
• constipation
• diarrhea
• difficulty urinating, or painful or painful urination
• difficult to speak
• dizzy
• sleepy
• heartburn
• restless
• underpowered
• leg cramps
• mental disorders
• nervous
• pounding
• sluggish
• stomach cramps
• thirsty
• tired
• limp

Not everyone experiences the above side effects. There may be some side effects not listed above. It should also be noted, the side effects vary from person to person.

If you have concerns about certain side effects, and even experience other conditions, please consult your doctor or pharmacist.

Other side effects of domperidone drugs

Domperidone is a drug commonly used to treat symptoms of nausea and vomiting in patients with Parkinson's disease (Parkinson's), and the risk of side effects is relatively small.

On the other hand, cardiotoxicity or damage to the heart muscle due to the consumption of the drug domperidone is quite common. Even arrhythmias, sudden death, and heart attacks have been reported as a result of taking domperidone through high levels of infusion.

Although domperidone is the drug recognized as the first choice for treating the symptoms of nausea and vomiting due to Parkinson's disease, the use of doses above 30 mg per day should still be investigated and monitored by a doctor. Because this can trigger heart attacks and sudden death in elderly patients.

Precautions and Warnings

What should be known before using domperidone?

Tell your doctor if you:

• Allergy (hypersensitivity) to domperidone or other ingredients containing domperidone
• Signs of an allergic reaction include: rash, difficulty breathing, swelling of the lips, face, throat, or tongue
• Have a pituitary gland tumor (prolactinoma)
• Black, bloody, dark bowel movements that can indicate gastric or intestinal bleeding
• Blocked or torn intestine
• Suffering from or have had liver problems

Is this drug safe for pregnant and lactating women?

There is not enough research into the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication.

The reason is, Foods and Drugs Administration or the FDA in the United States (the equivalent of the Indonesian Food and Drug Administration) is taking action on reports that some women who are breastfeeding or pumping breast milk buy this drug to increase their milk production. Domperidone is known to increase the secretion of prolactin, a hormone required by lactation.

This drug is included in the risk of pregnancy category C according to the FDA in the United States. The following references the risk category for pregnancy:

• A = Not at risk
• B = No risk in several studies
• C = May be risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

Drug Interactions

What medicines might interact with domperidone?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this description.

Keep a list of all the products you use (including prescription drugs, non-prescription drugs, and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Although certain drugs cannot be used together, in other cases two different drugs can be used together although drug interactions may occur. In this case, the doctor can change the dose, or other warnings may be needed.

While you are using this medicine it is very important for your doctor to know if you are taking any of the drugs mentioned below. The following interactions were selected based on differences in drug potential and not necessarily all included.

Using this medication with the drugs below is usually not recommended. Your doctor may decide not to treat you with this drug or change some of the drugs you are taking.

• yeast infection medicine (eg ketoconazole or pentamidine)
• antibiotics for infections (eg erythromycin, levofloxacin, or spiramycin)
• antidepressant drugs (citalopram or escitalopram)
• antihistamine or allergy medication (mequitaine or mizolastine)
• anti-arrhythmic drugs (disopyramide, hydroquinidine, quinidine, or sotalol)
• apomorphine

Can food or alcohol interact with this drug?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Smoking or consuming alcohol with certain drugs can also cause interactions to occur.

Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with this drug?

The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems, in particular:

• Bleeding from the stomach or other digestive problems
• Pituitary (brain) tumor
• Liver disease
• Sensitive to domperidone
• Kidney illness
• Heart disease

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency room.

Symptoms of an overdose that can be caused by taking domperidone are:

• So it's hard to talk
• Disorientation (dazed)
• Feel dizzy
• Fainting
• Heart rate becomes irregular
• The head was floating
• Loss of balance or loss of muscle control

What should I do if I miss a dose?

If you forget a dose of this medicine, take the normal dose as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule.

Better, don't, take medication that is not in accordance with the rules of the doctor can make your disease even worse. If it continues, of course this could allow you to be hospitalized, or even lead to death.

Forgetting to take medicine, increasing or decreasing the dose, carelessly putting down the medicine are mistakes that need to be avoided. Reporting from Food and Drug Administration in the United States, Centers for Disease Control and Prevention (CDC) states that carelessly taking medication causes 30-50 percent of treatment failures and 125,000 deaths per year.