Perindopril: functions, dosage, side effects, how to use

What Drug Perindopril?

What is Perindopril for?

Perindopril is a drug used to treat high blood pressure (hypertension). Lowering high blood pressure can help prevent strokes, heart attacks, and kidney problems. This drug is also used to prevent heart attacks in patients with certain types of heart disease (stable coronary artery disease).

Perindopril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so that blood can flow more easily.

OTHER USES: This section contains uses of this drug that are not listed on professional labels approved for this medicine, but which may be prescribed by your healthcare professional. Use this medication for the conditions listed in this section only if it has been so prescribed by your healthcare professional.

This drug can also be used to treat congenital heart failure and to help protect the kidneys from damage caused by diabetes.

How to use Perindopril?

Take this medication, usually once or twice daily or as directed by your doctor. Dosage is based on your medical condition and response to treatment. For the treatment of high blood pressure, drug manufacturers recommend using no more than 16 milligrams per day.

Use this remedy regularly for the most benefit. Remember to use it at the same time every day. Do not skip doses or stop taking this medication unless directed by your doctor. Keep taking this medication even if you feel well. Most people with high blood pressure don't feel sick. This medication may take up to several weeks before the full benefits take effect.

Tell your doctor if your condition gets worse, such as increasing blood pressure.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How is Perindopril stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Perindopril dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the Perindopril dosage for adults?

Usual Adult Dose for Coronary Artery Disease

Initial dose: 4 mg orally once a day for two weeks, then increase according to tolerance to a maintenance dose of 8 mg orally once a day.

Maintenance dose: 4 mg to 8 mg orally once a day.

Usual Adult Dose for Congenital Heart Failure

Initial dose: 4 mg orally once a day

Maintenance dose: 4 mg to 8 mg orally every day in one or two divided doses

Usual Adult Dose for Diabetes Nephropathy

Initial dose: 4 mg orally once a day

Maintenance dose: 4 mg to 8 mg orally every day in one or two divided doses

Usual Adult Dose for Hypertension

Initial dose: 4 mg orally once a day

Maintenance dose: 4 mg to 8 mg orally every day in one or two divided doses

Usual Adult Dose for Dysfunction
Left Ventricle

Initial dose: 4 mg orally once a day

Maintenance dose: 4 mg to 8 mg orally every day in one or two divided doses

Usual Adult Dose for Myocardial Infarction

Initial dose: 4 mg orally once a day

Maintenance dose: 4 mg to 8 mg orally every day in one or two divided doses

Usual parent dosage for Coronary Artery Disease

Over 70 years:

Initial dose: 2 mg orally once a day for the first week, followed by 4 mg orally once a day in the second week, then 8 mg orally once a day for maintenance if tolerated.

Maintenance dose: 4 mg to 8 mg orally once a day.

What is the dosage of Perindopril for children?

Safety and effectiveness have not been established in pediatric patients (less than 18 years).

In what dosage is Perindopril available?

Tablet

2 mg

4 mg

8 mg

Perindopril side effects

What side effects can I experience due to Perindopril?

Stop using perindopril and call your doctor if you have any of the following serious side effects:

• feeling like you might pass out
• fever, chills, body aches, flu symptoms, sores in mouth and throat
• urinating less than usual or not at all
• swelling, rapid weight gain
• high potassium level (slow heart rate, weak pulse, muscle weakness, tingling feeling)
• pale skin, easy bruising or bleeding
• jaundice (yellowing of the skin or eyes)

Less serious side effects may include:

• dizzy
• back pain
• cough

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Perindopril Drug Warnings and Cautions

What should be known before using Perindopril?

In deciding to use a drug, the risks of taking the drug must be carefully considered. This is up to you and your doctor. For this drug, the following should be considered:

Allergy

Tell your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to food, coloring, preservatives, or animals. For non-prescription products, read labels or ingredients carefully.

Children

Appropriate studies have not been carried out on the relationship of age to the effects of perindopril in the pediatric population. Safety and efficacy have not been confirmed.

Parents

The precise studies carried out to date have not shown specific problems in the elderly that will limit the usefulness of perindopril in the elderly.

Is Perindopril safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Studies in women show that this drug poses minimal risk to the baby when used during breastfeeding.

Perindopril Drug Interactions

What medicines may interact with Perindopril?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval

Taking this drug with any of the following medicines is not recommended. Your doctor may not prescribe this drug to you or will replace some of the drugs you are already taking.

• Aliskiren

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Alteplase, Recombinant
• Amiloride
• Azathioprine
• Azilsartan
• Candesartan Cilexetil
• Canrenoate
• Eplerenone
• Eprosartan
• Irbesartan
• Losartan
• Olmesartan Medoxomil
• Potassium
• Spironolactone
• Telmisartan
• Triamterene
• Trimethoprim
• Valsartan

Taking this medication with the drugs below may increase your risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Aceclofenac
• Acemetacin
• Amtolmetin Guacil
• Aspirin
• Azosemide
• Bemetizide
• Cyclopenthiazide
• Benzthiazide
• Bromfenac
• Bufexamac
• Bumetanide
• Bupivacaine
• Bupivacaine Liposome
• Buthiazide
• Capsaicin
• Celecoxib
• Chlorothiazide
• Chlorthalidone
• Choline Salicylate
• Clonixin
• Clopamide
• Cyclopenthiazide
• Cyclothiazide
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Dislunisal
• Dipyrone
• Ethacrynic Acid
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Furosemide
• Gold Sodium Thiomalate
• Hydrochlorothiazide
• Hydroflumethiazide
• Ibuprofen
• Ibuprofen Lysine
• Indapamide
• Indomethacin
• Ketoprofen
• Ketorolac
• Lithium
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Methyclothiazide
• Metolazone
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Niflumic Acid
• Nimesulide
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Phenylbutazone
• Piketoprofen
• Piretanide
• Piroxicam
• Polythiazide
• Pranoprofen
• Proglumetacin
• Propyphenazone
• Proquazone
• Quinethazone
• Rofecoxib
• Salicylic Acid
• Salsalate
• Sodium Salicylate
• Sulindac
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Torsemide
• Trichlormethiazide
• Valdecoxib
• Xipamide

Can food or alcohol interact with Perindopril?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with Perindopril?

The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems such as:

• Angioedema (swelling of the face, lips, tongue, throat, arms, or legs) with other ACE inhibitors, history. Can increase the risk of this condition happening again
• Collagen vascular disease (autoimmune disease) together with the risk of kidney disease. Increased blood problems
• Congenital heart failure, severe. Use can cause kidney problems
• Diabetes
• Kidney problems. Increased risk of potassium levels in the body becoming too high
• Diabetics who also use Aliskiren (Tunjukna®)
• Hereditary angioedema or idiopathic angioedema
• Patients with kidney disease who are also taking Aliskiren (Tesorna®) - should not be used in patients with this condition
• Electrolyte imbalance (eg low sodium in the blood)
• Fluid imbalance (caused by dehydration, vomiting, or diarrhea)
• Liver disease. Use with care. It might make things worse.

Perindopril overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.