Captopril and hydrochlorothiazide: functions, dosage, side effects, how to use

Captopril and Hydrochlorothiazide What Drugs?

What are captopril and hydrochlorothiazide for?

Captopril belongs to a class of drugs known as ACE inhibitors. This medicine works by calming the blood vessels so that blood can flow more easily. Meanwhile hydrochlorothiazide is a "water pill" (diuretic). This medicine increases the amount of your urine, which aims to flush out excess salt and fluids in the body.

Captopril and hydrochlorothiazide are commonly used to treat high blood pressure (hypertension). In addition, these two drugs are also used to help prevent strokes, heart attacks, and kidney problems. This drug may also be used to treat congestive heart failure.

Always consult a doctor first before deciding to take this drug.

How are captopril and hydrochlorothiazide used?

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist. Some things you should know before taking this drug include:

• Take this medication one hour before meals, usually once a day or as directed by your doctor. It is better to avoid taking this medicine within 4 hours before your bedtime, in order to avoid waking up at night to urinate. Consult your doctor or pharmacist if you have questions regarding the dosage schedule for drug use.
• Drink enough mineral water to prevent losing too much fluid in the body (dehydration). If your fluid intake is restricted, consult your doctor for further instructions.
• If you are also taking cholestyramine or colestipol drugs, take captopril / hydrochlorothiazide at least 4 to 6 hours after using either of these drugs.
• The dosage is based on the medical condition and response to treatment. The manufacturer recommends a daily dose of not more than 150 milligrams of captopril and 50 grams of hydrochlorothiazide.
• Take this medicine regularly to get optimal benefits. To help you remember, take this medication at the same time each day.
• Do not stop using this medication before consulting a doctor. It is very important to continue using this drug even if you feel better.
• Most people with high blood pressure do not feel significant side effects. It takes 6-8 weeks before the properties of this drug will be felt.

Tell your doctor if your condition worsens (for example, your routine reports of high blood pressure increase).

How are captopril and hydrochlorothiazide stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Captopril and Hydrochlorothiazide dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for captopril and hydrochlorothiazide for adults?

Standard adult dosage for congestive heart failure

• Initial dose: 1 tablet (captopril + hydrochlorothiazide 25 mg / 15 mg) taken once a day, one hour before meals. The dosage will depend on the patient's condition.
• Maintenance dose: Combination tablets can be given in divided doses up to 3 times a day. In general, the daily dose of captopril should not exceed 150 mg and hydrochlorothiazide should not exceed 50 mg.

Standard adult dosage for hypertension

• Initial dose: 1 tablet (captopril-hydrochlorothiazide 25 mg / 15 mg) taken once a day, one hour before meals. The dosage will depend on the patient's condition.
• Combination tablets can be given in divided doses up to 3 times a day. In general, the daily dose of captopril should not exceed 150 mg and hydrochlorothiazide should not exceed 50 mg.

What is the dosage of captopril and hydrochlorothiazide for children?

There is no provision for the dosage of this drug for children (less than 18 years). This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosages are captopril and hydrochlorothiazide available?

Captopril and hydrochlorothiazide are available in tablet form.

Captopril and Hydrochlorothiazide side effects

What side effects can be experienced due to captopril and hydrochlorothiazide?

Less serious side effects from using this drug include:

• Coughs
• Dizzy
• Headache
• Tired feeling
• Blurred vision
• Diarrhea
• Constipation
• Nausea
• Mild skin rash
• Sweating
• Allergic reactions

Tell your doctor right away if you experience serious side effects such as:

• Eye pain, visual disturbances.
• High levels of potassium in the body (slow heart rate, weak pulse, muscle weakness, tingling feeling).
• Low potassium levels (confusion, irregular heartbeat, excessive thirst, increased urine output, discomfort in the legs, muscle weakness or loss of balance)
• Dry mouth, thirst, nausea, vomiting.
• Feelings of weakness, drowsiness, restlessness, or lightheadedness.
• Redness, blisters, peeling, or a rash.
• Jaundice (yellowing of the skin or eyes).
• Urinating less frequently or not at all.
• Swelling, weight gain, shortness of breath.
• Fever, chills, body aches, flu symptoms.

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Captopril and Hydrochlorothiazide Drug Warnings and Cautions

What should be known before using captopril and hydrochlorothiazide?

Do not use this medication if you are allergic to hydrochlorothiazide or captopril, or if you:

• Have a history of asthma or allergies
• If you can't pee

You should not use this medication if you are allergic to ACE inhibitors, such as: benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Are captopril and hydrochlorothiazide safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA). The following references the pregnancy risk categories according to the FDA:

• A = Not at risk
• B = No risk in several studies
• C = May be risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

Captopril and Hydrochlorothiazide Drug Interactions

What medicines may interact with captopril and hydrochlorothiazide?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur.

In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Taking this drug with any of the following medicines is not recommended. Your doctor may not prescribe this drug to you or will replace some of the drugs you are already taking.

• Aliskiren
• Colchicine
• Dofetilide

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Acetyldigoxin
• Afatinib
• Allopurinol
• Alteplase, Recombinant
• Amiloride
• Arsenic Trioxide
• Azathioprine
• Azilsartan
• Bosutinib
• Candesartan Cilexetil
• Canrenoate
• Cyclophosphamide
• Dabigatran Etexilate
• Deslanoside
• Digitalis
• Digitoxin
• Digoxin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Droperidol
• Eplerenone
• Eprosartan
• Everolimus
• Flecainide
• Interferon Alfa-2a
• Irbesartan
• Ketanserin
• Levomethadyl
• Lithium
• Losartan
• Methotrexate
• Metildigoxin
• Morphine
• Morphine Sulfate Liposome
• Nilotinib
• Olmesartan Medoxomil
• Ouabain
• Pixantrone
• Pomalidomide
• Potassium
• Proscillaridin
• Romidepsin
• Sotalol
• Spironolactone
• Telmisartan
• Topotecan
• Trabectedin
• Triamterene
• Trimethoprim
• Valsartan
• Vincristine
• Vincristine Sulfate Liposome

Taking this medication with the drugs below may increase your risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Aceclofenac
• Acemetacin
• Alacepril
• Amtolmetin Guacil
• Aspirin
• Azosemide
• Bemetizide
• Benazepril
• Cyclopenthiazide
• Benzthiazide
• Bepridil
• Bromfenac
• Bufexamac
• Bumetanide
• Bupivacaine
• Bupivacaine Liposome
• Buthiazide
• Capsaicin
• Captopril
• Carbamazepine
• Celecoxib
• Chlorothiazide
• Chlorpromazine
• Chlorpropamide
• Chlorthalidone
• Cholestyramine
• Choline Salicylate
• Cilazapril
• Clonixin
• Clopamide
• Cyclopenthiazide
• Cyclothiazide
• Delapril
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Dislunisal
• Digoxin
• Dipyrone
• Enalaprilat
• Enalapril Maleate
• Ethacrynic Acid
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Flufenamic Acid
• Flurbiprofen
• Fosinopril
• Furosemide
• Ginkgo
• Glipizide
• Gold Sodium Thiomalate
• Gossypol
• Hydrochlorothiazide
• Hydroflumethiazide
• Ibuprofen
• Ibuprofen Lysine
• Icatibant
• Imidapril
• Indapamide
• Indomethacin
• Ketoprofen
• Ketorolac
• Licorice
• Lisinopril
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Methyclothiazide
• Metolazone
• Moexipril
• Morniflumate
• Nabumetone
• Naproxen
• Nepafenac
• Nesiritide
• Niflumic Acid
• Nimesulide
• Oxaprozin
• Oxyphenbutazone
• Parecoxib
• Pentopril
• Perindopril
• Phenylbutazone
• Piketoprofen
• Piretanide
• Piroxicam
• Polythiazide
• Pranoprofen
• Proglumetacin
• Propyphenazone
• Proquazone
• Quinapril
• Quinethazone
• Ramipril
• Rofecoxib
• Salicylic Acid
• Salsalate
• Sodium Salicylate
• Spirapril
• Sulindac
• Temocapril
• Tenoxicam
• Tiaprofenic Acid
• Tolfenamic Acid
• Tolmetin
• Topiramate
• Torsemide
• Trandolapril
• Trichlormethiazide
• Valdecoxib
• Xipamide
• Zofenopril

Can food or alcohol interact with captopril and hydrochlorothiazide?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with captopril and hydrochlorothiazide?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• Have a history of angiodema
• Anuria (unable to urinate)
• Asthma
• Diarrhea
• Heart failure
• Hyponatremia (low sodium in the blood)
• Kidney disease
• Diabetes
• Gout
• Hyperuricemia (high uric acid in the blood)
• Liver disease
• Systemic lupus erythematosus (SLE) —this condition can get worse

Captopril and Hydrochlorothiazide overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of an overdose include:

• Sleepy
• Coma
• Difficulty breathing
• Stomach ache

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.