Celecoxib: functions, dosage, side effects, how to use it

What medicine is Celecoxib?

What is Celecoxib for?

Celecoxib is a pain reliever medication that is often used to treat arthritis, gout, ankylosing spondylitis, and pain during menstruation. This drug belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), specifically COX-2 inhibitors, which reduce pain, swelling, and inflammation.

Celecoxib dosage and celecoxib side effects will be described further below.

How do I use Celecoxib?

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

Take this medication as directed by your doctor, usually once or twice a day. To reduce stomach upset, this drug is better taken at the same time as food. The dosage is based on the medical condition and response to treatment. Take celecoxib at the lowest dose and only for the specified time period (see warning section).

Take this medication with a full glass of mineral water (240 mL) unless otherwise advised by your doctor. Do not lie down for about 10 minutes after taking the medicine. In certain conditions (such as arthritis), it may take up to two weeks of regular use of the drug before you get full efficacy.

If you are taking this medication "as needed" (not on a daily schedule), remember that it will work best if it is taken at the first sign of pain. If you wait for the pain to get worse, the medicine may not work very well.

How do I store Celecoxib?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Celecoxib dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Celecoxib for adults?

For treating acute pain, the dose of celecoxib is 400 mg at baseline, followed by 200 mg if needed on the first day. Then 200 mg twice a day as needed.

The dosage will depend on the condition of each patient.

What is the dosage of Celecoxib for children?

Children 2 years of age or older

To overcome Juvenile Rheumatoid Arthritis, doses of celecoxib are in the range of 50 - 100 mg taken by mouth twice a day. The dose of the drug will depend on the child's age and body weight.

In what dosage is Celecoxib available?

The available doses of celecoxib are:

• Capsules, oral: 50mg, 100mg, 200mg, 400mg

Celecoxib side effects

What side effects can be experienced due to Celecoxib?

The most common side effects of using the drug celecoxib are:

• Stomach disorders such as diarrhea, bloating, passing wind
• Dizziness, restlessness, headache
• Runny nose or congestion
• Sore throat
• Mild skin rash
• Allergic reactions

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Celecoxib Drug Warnings and Cautions

What should be known before using Celecoxib?

Some things you should know before using celecoxib are:

• Do not use celecoxib before or after heart bypass surgery (coronary artery bypass graft, or CABG). This medicine can threaten heart conditions or circulation problems such as heart attack or stroke, especially if used for a long time.
• This medication may also cause serious effects on the stomach or digestion, including bleeding or perforation (hole formation).
• You should not use this medication if you have an allergy to celecoxib, or if you have a history of allergies to aspirin, sulfa drugs, or other NSAID drugs.

Is Celecoxib safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA). The following references the pregnancy risk categories according to the FDA:

• A = Not at risk
• B = No risk in several studies
• C = May be risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

Celecoxib Drug Interactions

What medicines may interact with Celecoxib?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Using this medication with any of the following drugs is not recommended. Your doctor may decide not to treat you with this drug or change some of the medicines you have used.

• Ketorolac

Using this medication with any of the following drugs is usually not recommended, but may be needed in some cases. If both drugs are prescribed together, your doctor may change the dose or the frequency with which you use one or both drugs.

• Abciximab
• Anagrelide
• Apixaban
• Ardeparin
• Argatroban
• Beta Glucan
• Bivalirudin
• Ceritinib
• Certoparin
• Cilostazol
• Citalopram
• Clopidogrel
• Clovoxamine
• Cyclosporine
• Dabigatran Etexilate
• Dabrafenib
• Dalteparin
• Danaparoid
• Desirudin
• Dipyridamole
• Duloxetine
• Enoxaparin
• Eptifibatide
• Erlotinib
• Escitalopram
• Femoxetine
• Feverfew
• Flesinoxan
• Fluoxetine
• Fondaparinux
• Ginkgo
• Gossypol
• Heparin
• Lepirudin
• Levomilnacipran
• Meadowsweet
• Methotrexate
• Milnacipran
• Nadroparin
• Nefazodone
• Nitisinone
• Parnaparin
• Paroxetine
• Pemetrexed
• Pentosan Polysulfate Sodium
• Pentoxifylline
• Pralatrexate
• Prasugrel
• Protein C
• Reviparin
• Rivaroxaban
• Sibutramine
• Tacrolimus
• Ticlopidine
• Tinzaparin
• Tirofiban
• Venlafaxine
• Vilazodone
• Vortioxetine
• Warfarin
• Zimeldine

Using this medication with one of the following drugs will increase your risk of certain side effects, but taking the two drugs at the same time may be the best treatment for you. If both drugs are prescribed together, your doctor may change the dose or frequency of use of one or both drugs.

• Acebutolol
• Acetohexamide
• Alacepril
• Alprenolol
• Amiloride
• Amlodipine
• Arotinolol
• Aspirin
• Atenolol
• Azilsartan Medoxomil
• Azosemide
• Befunolol
• Bemetizide
• Benazepril
• Cyclopenthiazide
• Benzthiazide
• Bepridil
• Betaxolol
• Bevantolol
• Bisoprolol
• Bopindolol
• Bucindolol
• Bumetanide
• Bupranolol
• Buthiazide
• Candesartan Cilexetil
• Canrenoate
• Captopril
• Carteolol
• Carvedilol
• Celiprolol
• Chlorothiazide
• Chlorpropamide
• Chlorthalidone
• Cilazapril
• Clopamide
• Cyclopenthiazide
• Delapril
• Desvenlafaxine
• Dilevalol
• Diltiazem
• Enalaprilat
• Enalapril Maleate
• Eprosartan
• Esmolol
• Ethacrynic Acid
• Felodipine
• Fluconazole
• Flunarizine
• Fosinopril
• Furosemide
• Gallopamil
• Gliclazide
• Glimepiride
• Glipizide
• Gliquidone
• Glyburide
• Hydrochlorothiazide
• Hydroflumethiazide
• Imidapril
• Indapamide
• Irbesartan
• Isradipine
• Labetalol
• Lacidipine
• Landiolol
• Levobunolol
• Lidoflazine
• Lisinopril
• Lithium
• Losartan
• Manidipine
• Mepindolol
• Methyclothiazide
• Metipranolol
• Metolazone
• Metoprolol
• Moexipril
• Nadolol
• Nebivolol
• Nicardipine
• Nifedipine
• Nilvadipine
• Nimodipine
• Nipradilol
• Nisoldipine
• Nitrendipine
• Olmesartan Medoxomil
• Oxprenolol
• Penbutolol
• Pentopril
• Perindopril
• Pindolol
• Piretanide
• Polythiazide
• Pranidipine
• Propranolol
• Quinapril
• Ramipril
• Sotalol
• Spirapril
• Spironolactone
• Talinolol
• Tasosartan
• Telmisartan
• Temocapril
• Tertatolol
• Timolol
• Tolazamide
• Tolbutamide
• Torsemide
• Trandolapril
• Triamterene
• Trichlormethiazide
• Valsartan
• Verapamil
• Xipamide
• Zofenopril

Can food or alcohol interact with Celecoxib?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Celecoxib?

Some of the health conditions that may interact with the drug celecoxib are:

• Anemia
• Congestive heart failure
• Edema (fluid retention or swelling in the body)
• Have a history of heart attack
• Heart disease
• Hypertension (high blood pressure)
• Kidney disease, mild to moderate
• Have a history of stomach ulcers or bleeding
• Have a history of stroke
• Aspirin-sensitive asthma
• Sensitive to aspirin
• Severe kidney problems
• Severe liver problems
• Sulfa or sulfonamide allergy (for example, sulfamethoxazole, bactrim®, or septra®) - should not be used in patients with these conditions
• Heart surgery (for example, coronary artery bypass graft surgery) - this medication should not be used to relieve pain before or after surgery
• Certain genetic conditions (low cyp2c9 (liver enzyme) metabolism)
• Liver disease, mild or moderate — use with caution. You may need to decrease the dose of medication

Celecoxib overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of an overdose of the drug celexocib are:

• Lack of energy
• Sleepy
• Nausea
• Throws up
• Stomach ache
• Vomits blood or looks like coffee grounds
• Bloody or clay-colored stools
• Loss of consciousness
• Itchy rash
• Rash
• Swelling of the eyes, face, tongue. lips, throat, arms, hands, feet, ankles or lower legs
• Difficulty breathing or swallowing

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.