Danazol: functions, dosage, side effects, how to use it

Danazol What Medicine?

What is Danazol for?

Danazol is a drug used by women to treat pelvic pain and immersion due to uterine disorders (endometriosis). In addition, danazol is a drug that is also used to treat breast pain and nodules that arise due to breast conditions (fibrocystic breast disease). This drug is also consumed by men and women to prevent swelling of the stomach, arms, legs, face, respiratory tract caused by a congenital disease (hereditary angioedema).

Danazol is a drug that contains androgen hormones similar to testosterone. For the treatment of endometriosis and treatment of fibrocystic breast disease, this drug works to reduce the amount of hormones produced by the ovaries. These hormones usually worsen the condition of the body. For the treatment of angioedema, danazol helps increase the amount of certain proteins in your immune system (immune system).

Danazol dosage

How to use this drug?

Danazol is a medicine that is taken orally, usually twice daily or as directed by your doctor. You can take this drug with or without food, but the most important thing is to take this drug in the same way and dosage.

The dosage is based on your medical condition and your body's response to treatment

Use this drug regularly to get maximum results. You are advised to take this drug at the same time every day. Tell your doctor if your condition does not improve or if it gets worse.

How to store this drug?

Danazol is a drug that is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Pay attention to the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Danazol side effects

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Danazol for adults?

• Endometriosis

The usual dose for the treatment of endometriosis for adults is 100 mg to 200 mg orally twice a day. For the treatment of severe endometriosis a starting dose of 400 mg orally twice daily may be required.

To ensure that the patient is not pregnant, therapy should be started during menstruation. If this is not possible, a pregnancy detection test should be done to make sure the patient is not pregnant. Non-hormonal birth control methods are recommended for sufferers of this disease.

After knowing the body's response to the use of the initial dose (amenorrhea developing), the follow-up dose should be titrated to the minimum dose that suppresses disease movement.

Treatment should be carried out for 3 to 6 months on a regular basis. Even if needed, Danazol can be consumed for up to 9 months. If some symptoms appear in the body, treatment with Danazol can still be started again.

• Fibrocystic breast

The usual dose for the treatment of fibrocystic breast disease is 50 mg to 200 mg orally twice a day.

To ensure that the patient is not pregnant, therapy should be started during menstruation. If this is not possible, a pregnancy detection test should be done to make sure the patient is not pregnant. Non-hormonal birth control methods are recommended for sufferers of this disease.

Aches and pains usually occur within 1 to 3 months of treatment. Meanwhile, to get rid of nodules (swelling) it takes 4 to 6 months of regular treatment. Some symptoms will appear within one year of treatment in 50% of sufferers of this disease. However, treatment can still be started again.

• Angiodema

The usual dose for the treatment of angioedema is 200 mg orally, two to three times a day.

To ensure that the patient is not pregnant, therapy should be started during menstruation. If this is not possible, a pregnancy detection test should be performed to ensure that the patient is not pregnant. Non-hormonal birth control methods are recommended for those with this disease.

After knowing the body's response to the use of the initial dose of the drug (prevention of edema development), treatment should be carried out at intervals of 1 to 3 months by reducing the dose of drug use per interval. A reduction in drug dosage by up to 50% should be considered. If angioedema recurs, the daily dose can be increased to 200 mg.

What is the dosage of Danazol for children?

Danazol is a drug whose dosage is unknown for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosages is Danazol available?

Danazol is a drug that is available in capsules of 50 mg, 100 mg and 200 mg.

Danazol Drug Warnings and Cautions

What side effects can I experience due to Danazol?

Common side effects include weight gain, acne, skin flushing, sweating, voice changes, hair growth on the body (female, vaginal dryness / irritation, or reduced breast size.

Not everyone experiences these side effects. There may be some side effects not listed above. If you are concerned about any side effects, please consult your doctor or pharmacist.

Danazol Drug Interactions

What should be known before using Danazol?

Before taking Danazol, pay attention to the following

• Tell your doctor and pharmacist if you are allergic to danazol or any other medicines.
• Tell your doctor and pharmacist any medications you are taking (with or without a prescription), especially anticoagulants (blood thinners) such as warfarin (Coumadin). diabetes medications such as insulin; drugs for seizure, especially carbamazepine (Tegretol); and also tell the types of vitamins you are taking.
• Tell your doctor if you have ever had migraines. heart, liver, or kidney disease; seizures (epilepsy); or have had a stroke, blood clot, or breast cancer.

Is Danazol safe for pregnant and breastfeeding women?

Danazol is a drug whose effects on pregnant and lactating women are not yet known. There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category X according to the Food and Drug Administration (BPOM) in America.

Following are references to pregnancy risk categories according to the Food and Drug Administration (BPOM) in America

:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

There are no definite studies on the risk that occurs to the baby if a breastfeeding mother takes this drug during breastfeeding. However, you still have to consider the benefits and potential risks that arise before taking this drug.

Danazol overdose

What medicines may interact with Danazol?

Danazol is a drug that can interact with other drugs. Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Taking this drug with any of the following medicines is not recommended. Your doctor may not prescribe this medicine to you or will replace some of the drugs you are already taking.

• Simvastatin

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Anisindione
• Atorvastatin
• Bupropion
• Dicumarol
• Fluvastatin
• Lovastatin
• Phenprocoumon

Taking this medication with the drugs below may increase your risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Carbamazepine
• Cyclosporine
• Tacrolimus
• Warfarin

Can food or alcohol interact with Danazol?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Danazol?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• There is abnormal bleeding in the vagina or
• The occurrence of blood clots or
• Suffering from heart disease or
• Suffering from kidney disease or
• Suffering from liver disease or
• Suffering from Porphyria (enzyme problems) or
• Tumors appear due to too much androgens (male hormones) - should not be taken by patients with this condition.
• Diabetes or
• Epilepsy or
• Fluid retention or edema (swelling of the body by fluids) or
• Heart failure or
• Hypertension (high blood pressure) or
• Kidney failure or
• Migraine headaches or
• Polycythemia (blood disease) - Taking Danazol can worsen the condition of the body, especially causing fluid retention (too much fluid in the body).

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.