Flumazenil: functions, dosage, side effects, how to use

Functions & Usage

What is the drug Flumazenil used for?

Flumazenil is a drug used to relieve drowsiness, a drunken sensation, and other effects caused by benzodiazepines.

Flumazenil is a benzodiazepine antagonist. These drugs work by blocking receptors in the brain and central nervous system from activating benzodiazepines, helping to reduce drowsiness and the effects of anesthesia.

How do you use the drug Flumazenil?

Take flumazenil as directed by your doctor. Check the drug label for precise dosing instructions.

Flumazenil is usually given as an injection by a doctor in a doctor's office, hospital, or clinic. If you are using flumazenil at home, carefully follow the injection procedures taught to you by your healthcare provider.

Do not use flumazenil if this medicine contains foreign particles or changes color, or if the bottle is cracked or damaged for any reason.

If flumazenil accidentally gets on your skin, wash it off immediately with soap and water.

Keep this product, as well as syringes and syringes, out of the reach of children and from pets. Do not reuse syringes, needles, or other materials. Discard properly after use. Ask your doctor or pharmacist to explain the regulations for the correct disposal of medical equipment.

If you miss a dose of flumazenil, contact your doctor immediately.

Ask your doctor any questions you have about how to use flumazenil.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How to store Flumazenil?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Precautions & Warnings

What should be considered before using the drug Flumazenil?

Before using Flumazenil, tell your doctor if:

• You are allergic to any of the ingredients in flumazenil or benzodiazepines (for example, alprazolam)
• You have been given a benzodiazepine to control a potentially life-threatening condition (for example, increased pressure in the head, seizures)
• You experience the side effects of an overdose of a drug used to treat depression

Is the drug Flumazenil safe for pregnant and lactating women?

• Pregnancy

Flumazenil has been classified as pregnancy category C by the FDA. Animal studies have failed to reveal evidence of a teratogenic effect. Increased embryonic mortality has been reported in rabbits treated with doses greater than 60 times the maximum recommended human dose. No data on human pregnancy. Flumazenil is only recommended for use during pregnancy when the benefits outweigh the risks. The use of flumazenil during labor and delivery is not recommended.

• Breastfeeding:

There are no data on the excretion of flumazenil into human milk. The manufacturer recommends caution when administering flumazenil to breastfeeding women.

Side effects

What are the possible side effects of Flumazenil?

Get emergency medical help if you have any of these signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, difficulty breathing, swelling of your face, lips, tongue, or throat, or feel like you might pass out.

Stop using Flumazenil and call your doctor if you have any of the following serious side effects:

• Seizures
• Weak or shallow breathing
• Continue to be drowsy for more than 2 hours after receiving flumazenil
• Confusion, fear, panic attacks
• Fast or uneven heartbeat

Less serious side effects include:

• Pain or irritation where the medicine was injected
• Agitation or tremors (shaking)
• Warmth, redness, or tingling under your skin
• Dizzy
• Sweating or chills
• Headache
• Blurred vision
• Ringing in ears

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Interactions

What medicines can interfere with the drug Flumazenil?

Some DRUGS MAY INTERACT with flumazenil. However, no specific interactions with flumazenil are known at this time.

This list may not be a complete list of all possible interactions. Ask your doctor if flumazenil might interact with other medicines you are taking. Check with your doctor before you start, stop, or change the dose of any medicine.

Can certain foods and drinks interfere with the drug Flumazenil?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interfere with the performance of the drug Flumazenil?

The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems, such as:

• If you are pregnant, planning to become pregnant, or are breastfeeding
• If you are taking prescription or nonprescription drugs (especially benzodiazepines), herbs, or dietary supplements
• If you have an allergy to drugs, food, or other substances
• If you have a history of seizures, panic disorder, liver disorders, alcohol or other substance abuse, or you have had a recent head injury

Dose

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Flumazenil for adults?

Usual Adult Dose to Counter the Effects of Sedation

Initial dose: 0.2 mg IV once for 15 seconds.

Repeat dose: 0.2 mg can be repeated every minute until the desired level of consciousness is reached. The maximum total dose is 1 mg. Most patients receive a dose of 0.6-1 mg.

Resedation dose: 0.2 mg every minute up to a total of 1 mg / dose and 3 mg / hour.

Usual Adult Dose for Benzodiazepine Overdose

Initial dose: 0.2 mg IV once for 30 seconds.

Repeat dose: 0.5 mg can be repeated every minute. The maximum total dose is 3 mg. Some patients who receive a dose of 3 mg may receive an additional dose of up to 5 mg. Most patients receive a dose of 1-3 mg.

Resedation dose: 0.5 mg every 20 minutes for a total of 1 mg / dose and 3 mg / hour.

What is the dosage of the drug Flumazenil for children?

Usual Children's Dose for Reversal of Sedation

IV:

Infants and Children: Benzodiazepine antidotes when used in conscious sedation or general anesthesia:

Initial dose: 0.01 mg / kg (maximum dose: 0.2 mg) given for 15 seconds; can be repeated 0.01 mg / kg (maximum dose: 0.2 mg) after 45 seconds, and then every minute for a maximum total cumulative dose of 0.05 mg / kg or 1 mg, whichever is lower; Commonly used total dose: 0.08-1 mg (average: 0.65 mg)

Management of benzodiazepine overdoses: little available information;

Initial dose: 0.01 mg / kg (maximum dose: 0.2 mg) with repeated doses of 0.01 mg / kg (maximum dose: 0.2 mg) given every minute for a maximum total cumulative dose of 1 mg; as an alternative to repeated bolus doses, a continuous infusion of 0.005-0.01 mg / kg / hr can be used; further study is needed.

Usual Children's Dose for Benzodiazepine Overdose

1-17 years:

Initial dose: 0.01 mg / kg IV over 15 seconds.

Repeat dose: 0.01 mg / kg given for 15 seconds; can be repeated 0.01 mg / kg after 45 seconds, then every minute for a maximum total cumulative dose of 0.05 mg / kg. Continuous IV infusion: 0.005-0.01 mg / kg / day used in preterm conditions (gestational age: 32 weeks) exposed to high doses of intrapartum diazepam.

Benzodiazepine-induced myoclonus:

IV:

0.078 mg / kg is effective in a single, full-term neonate receiving continuous midazolam infusion.

In what dosages and preparations is Flumazenil available?

Solution, intravenous: 0.5 mg / 5 mL (5 mL), 1 mg / 10 ml (10 ml)

What to do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (119) or immediately to the nearest hospital emergency department.

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.