Santibi plus: functions, dosage, side effects, how to use it

Use

What is the santibi plus used for?

Santibi Plus is a oral medicine in the form of tablets containing ethambutol HCl, isoniazid, and pirydoxine (vitamin B6).

The main active ingredients, ethambutol and isoniazid, are included in the class of antibiotic drugs that both work by stopping the growth of bacteria in the body.

Meanwhile, pirydoxine is used to treat vitamin B6 deficiency in the body that usually occurs as a result of taking drugs such as isoniazid.

This drug is included in the class of prescription drugs that can only be used as directed by a doctor and is obtained at a pharmacy using a prescription from a doctor. This drug is an anti-tuberculosis drug used to treat tuberculosis infection and prevent tuberculosis infection in people who have been infected with TB bacteria.

How do you use the Santibi Plus?

Using Santibi Plus must be in accordance with the rules for drug use, as follows.

• Follow the directions given by the doctor on the prescription paper.
• Your doctor may change your dose at any time according to your health condition.
• Do not use this medication in an amount more or less than the dose prescribed by your doctor.
• This medicine can be taken before or after meals, but this medicine should be taken at least 1-2 hours before meals or when the stomach is still empty.
• Try not to miss a dose of this medicine, as this can increase the risk of a more severe infection.
• You should have your eyes and liver checked frequently while using this medicine.

How do you save the Santibi Plus?

Santibi Plus is stored as follows.

• Santibi Plus should be placed in a place with room temperature, not too hot and not too cold.
• This medicine should be kept away from places that are damp and easily exposed to direct light.
• Do not store this medication in the bathroom.
• Do not store and freeze in the freezer.
• Do not place this medication in a place that is easily accessible to children or pets.

Meanwhile, Santibi Plus is disposed of in the following ways.

• This medicine should be discarded immediately if it is no longer used or if its validity period has expired.
• Do not flush this medication in the toilet or into drains.
• Discard this medication according to the directions on the drug packaging. If you are unsure about the correct way to dispose of your medicine, ask your pharmacist or a local waste disposal authority about how to safely dispose of your medicine.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the Santibi Plus dosage for adults?

Adult dosage for tuberculosis infection

• Initial dose: 3 tablets taken once a day.
• Maintenance dose: 4 tablets taken once a day.

After that, the drug is used at a dose of 15 milligrams (mg) / kilogram (kg) / day.

What is the dose of santibi plus for children?

Children's dosage for tuberculosis infection

This medicine should only be used by children over 13 years of age:

• Initial dose: 3 tablets taken once a day.
• Maintenance dose: 4 tablets taken once a day.

After that, the drug is used at a dose of 15 milligrams (mg) / kilogram (kg) / day.

In what dosage is Santibi Plus available?

Tablets with the active ingredient ethambutol HCl 250 mg, 100 mg isoniazid, and 6 mg vitamin B6.

Side effects

What are the possible side effects of using Santibi Plus?

The side effects of using santibi plus that may occur due to the ethambutol and isoniazid content in it are:

• Blurred eyesight and unable to focus. In fact, your vision may be lost and it can last up to an hour or more.
• Use of this medication may also increase the sensitivity of your eyes to light.
• Your eyeball hurts when you move it, so that the back of your eye hurts.
• Fever accompanied by coughing that makes it difficult for you to breathe.
• Numbness in your hands or feet.
• The body feels weak and you suddenly get sick and won't heal after three days.
• Jaundice (yellow eyes and skin) to dark urine and clay-colored stools.
• Seizures
• There is swelling of the glands.
• You feel confused until you hallucinate.
• Some parts of your body bleed easily (nosebleeds, or bleeding gums).
• Can't urinate at all.
• Liver disorders

If you experience the side effects that occur above, stop using Santibi Plus and contact your doctor immediately. Meanwhile, there are also other side effects that are milder but more common, such as:

• Skin rash or itchy skin
• The joint hurts
• Headache
• Nausea and vomiting, to constipation and loss of appetite.

Warnings & Precautions

What should be known before using Santibi Plus?

Before using santibi plus, there are a number of things you should know and pay attention to, such as the following.

• Do not use this medicine if you have liver problems, because the isonazide content in it may interact with your condition.
• Make sure you know that taking drugs containing isoniazid can cause fatal liver problems, especially if you are 35-65 years of age.
• Also, make sure that you know that using Santibi Plus can cause vision problems. Therefore, let the doctor first check the health condition of your eyes to find out whether it is safe for you to use ethambutol.
• Avoid consuming alcohol while using drugs containing isoniazid as it can damage your liver condition.
• Make sure that Santibi Plus which contains isoniazid is safe for you to use. Therefore, tell your doctor if you have certain health conditions such as liver problems, kidney failure, neurological disorders, diabetes, or HIV.
• Tell your doctor if you regularly consume alcohol.
• Tell your doctor if you have a nutritional deficiency.
• Tell your doctor if you are using intravenous drugs.
• Tell your doctor if you have ever stopped using any medicines that contain isoniazid.
• Before starting to use the drug, you should undergo an enzyme test in your liver to determine whether it is safe for you to use Santibi Plus. Especially if you are over 35 years of age.
• This medicine should not be given to children under 13 years of age.

Is santibi plus safe for use by pregnant and lactating women?

It is still not known with certainty whether this drug can affect pregnant women. However, the US Food and Drug Administration (FDA) or the equivalent of the Food and Drug Administration (BPOM) in Indonesia includes the two main active ingredients of Santibi Plus, namely ethambutol and isoniazid, into the risk of pregnancy category C.

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Meanwhile, there is no evidence that Santibi Plus can be released from breast milk and consumed by a breastfeeding baby. If you are going to use this drug, you should first consult your doctor about the risks and benefits of using it. Only use this medication if the benefits outweigh the risks of using it.

Interaction

What drugs can interact with Santibi Plus?

There are several drugs that can interact with Santibi Plus. Due to the content of its main active ingredients, namely ethambutol and isoniazid, santibi plus can most often interact with the following medicines:

• Acetaminophen
• Cymbalta (duloxetine)
• Humira (adalimumab)
• Leflunomide
• Lomitapide
• Rifampin
• Singulair
• Tylenol
• Vigabatrin

What food and alcohol can the santibi plus interact with?

Certain medications should not be consumed at mealtimes or when eating certain types of food because interactions may occur. Consuming alcohol or tobacco-derived products with certain drugs can also cause interactions. Discuss with your health care professional the use of drugs with food, alcohol, or products derived from tobacco.

What health conditions can the santibi plus interact with?

The use of Santibi Plus can interact with several health conditions, such as:

• Liver disorders
• Hemodialysis, or blood washing
• Kidneys that can't function properly
• Hyperuricemia, uric acid levels in the blood that increase beyond normal limits
• Optic neuritis, which is inflammation of the optic nerve
• Eriferous neuropathy, which is a disorder of the peripheral nervous system

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you miss a dose, take the missed dose immediately. But if time indicates to take the next dose, skip the missed dose and keep taking the medication according to the usual schedule. Do not double your dose as you do not know the risk of side effects of this TB medicine if you use multiple doses and this does not guarantee you will get better sooner.

Hello Health Group does not provide medical advice, diagnosis or treatment.