Tigecycline: functions, dosage, side effects, how to use

What Drug Tigecycline?

What is Tigecycline for?

Tigecycline is a drug used to treat certain serious bacterial infections and may be resistant to other antibiotics. This drug is known as the glycycline antibiotic.

It is in the tetracycline class of antibiotics. Works by stopping bacterial growth.

How do I use Tigecycline?

This medication is given by injection into the pulse within 30-60 minutes by a healthcare provider. The dose is usually repeated every 12 hours or as directed by your doctor. The dose and length of treatment will depend on your condition and response to therapy.

If you are using this medicine yourself at home. Learn all preparation and usage instructions from your healthcare provider. Gently stir the medicine into the mixture. Don't shake it. The medicinal mixture should be yellow to orange in color. Before use, inspect this product visually for particles or a green / black discoloration. If there is either of the two, do not use the liquid. Learn how to store and dispose of medical equipment safely.

Antibiotics work best when the amount of the drug in the body is kept at a constant level. So, use this drug at even intervals of time.

Continue to use this medication until the prescribed amount is finished even though the symptoms have disappeared within a few days. Stopping the drug too quickly allows the bacteria to continue to grow, which can lead to a return of infection.

Tell your doctor if your condition gets worse or doesn't get better within 14 days.

How do I store Tigecycline?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Tigecycline dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Tigecycline for adults?

Dosage for intraabdominal infections in adults:

The initial dose is 100 mg intravenously, followed by 50 mg intravenously every 12 hours

Duration of therapy: 5 to 14 days

Approved indications: for the treatment of complications of intraabdominal infections due to immunity Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, K pneumoniae, Enterococcus faecalis (vancomycin-susceptible to immunity), Staphylococcus aureus (methicillin-susceptible and - susceptible to resistance), Streptococcus group Anginosus (including S Anginosus, S intermedius, and S constellatus), Bacteroides fragilis, B thetaiotaomicron, B uniformis, B vulgatus, Clostridium perfringens, and Peptostreptococcus micros

Dosage for skin and soft tissue infections in adults:

The initial dose is 100 mg intravenously, followed by 50 mg intravenously every 12 hours

Duration of therapy: 5 to 14 days

Dosage for skin and structure infections in adults:

The initial dose is 100 mg intravenously, followed by 50 mg intravenously every 12 hours

Duration of therapy: 5 to 14 days

Dosage for pneumonia infection in adults:

The initial dose is 100 mg intravenously, followed by 50 mg intravenously every 12 hours

Duration of therapy: 7 to 14 days

What is the dosage of Tigecycline for children?

Dosage for intraabdominal infections in children:

For complications of infection:

Ages 8 to 11 years: 1.2 mg / kg intravenously every 12 hours

maximum dose 50 mg / dose

Ages 12 to 17 years: 50 mg intravenously every 12 hours

Dosage for skin and structure infections in children:

For complications of infection:

Ages 8 to 11 years: 1.2 mg / kg intravenously every 12 hours

maximum dose 50 mg / dose

Ages 12 to 17 years: 50 mg intravenously every 12 hours

Dosage for pneumonia infection in children:

For pneumonia due to transmitted bacteria:

Ages 8 to 11 years: 1.2 mg / kg intravenously every 12 hours

maximum dose 50 mg / dose

Ages 12 to 17 years: 50 mg intravenously every 12 hours

In what dosage is Tigecycline available?

Injection 5 ml; 10 ml.

Tigecycline side effects

What side effects can be experienced due to Tigecycline?

If you experience signs of an allergic reaction to this medicine, seek medical attention immediately: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

Stop using tigecycline and contact your doctor if you experience serious side effects such as:

• Diarrhea that is watery or bloody;
• Severe headaches, ear pressure, dizziness, nausea, vision problems, and pain behind the eyes;
• Nausea, upper stomach pain, itching, loss of appetite, dark urine, pale, yellow stools on the skin or eyes); or
• Severe pain in the upper abdomen radiating to the back, nausea and vomiting, rapid heart rate.

Mild side effects include:

• Dizziness, sleep problems (insomnia);
• Headache; or
• Itching or discharge from the vagina.

Not everyone experiences the above side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Tigecycline Drug Warnings and Cautions

What should be known before using Tigecycline?

When deciding to use a drug, the risks and benefits of the drug must be considered. This is a joint decision of you and your doctor. For this drug, the following should be considered:

Allergy

Tell your doctor if you have had an unusual or allergic reaction to this drug or any other medicine. Tell your health care provider if you have any other allergies such as food allergies, food coloring, preservatives, or animals. For non-prescription products, read the composition on the label or packaging carefully.

Children

The use of tigecycline injection in children is not recommended. Safety and efficacy are unknown.

Tigecycline can cause permanent tooth discoloration and slow bone growth. This medicine should not be given to children aged 8 years or younger, unless as directed by a pediatrician.

Elderly

Research that has been done to date has not shown the specific problems that limit the use of phenols in the elderly.

Is Tigecycline safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Tigecycline Drug Interactions

What medicines may interact with Tigecycline?

Although certain drugs are not recommended to be used together, in other cases two different drugs can be used together even though drug interactions may occur. In these cases, your doctor may change the dose, or other precautions need to be taken. Tell your health care provider if you are using other prescription or nonprescription drugs.

Using this medication with the following drugs may increase your risk of certain side effects, but using both drugs may be the best treatment for you. If both drugs are prescribed together, your doctor may change the dose or how often one or both drugs are used.

• Tacrolimus
• Warfarin

Can food or alcohol interact with Tigecycline?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions may interact with Tigecycline?

The presence of other health problems can affect the use of this drug. Tell your doctor if you have other health problems, specifically:

• Diarrhea or
• Liver disease or
• Pancreatitis (inflammation of the pancreas) —use with caution. Can aggravate the condition.
• Severe liver disease — use with caution. The effect may increase due to the slower disposal of the drug from the body

Tigecycline overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of an overdose can include:

• Nausea
• gag

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.