Is it true that appendicitis was passed down from parents? & bull; hello healthy

Appendicitis (appendicitis) is a condition characterized by inflammation of the appendix. Appendectomy is the most commonly performed emergency surgical procedure and accounts for 1-2% of all surgical operations. Acute appendicitis is quite common and most sufferers are adolescents and young adults. In the century since the discovery of the disease, there has been no progress in explaining the etiology and pathogenesis of appendicitis. According to the leading theory, the initial occurrence of acute appendicitis is narrowing of the lumen by factors such as foreign bodies, intestinal parasites, tumors, or enlargement of lymphoid follicles due to viral infection. However, a constriction of the duct has also been identified in 30-40% of appendicitis that has been eliminated. Then, are all cases of appendicitis related to lowered eyebrows? You can see a complete explanation below.

Is the appendix actually lowered?

Family history

First, in 1937, Baker described a family tree in which 50% of the family was operated on for appendicitis. Andersson et al. and also Arnbjornsson demonstrated a high incidence of appendicitis among close family members. Hiraiwa et al. found in their large-scale study in Japan, that about 40% of children with both parents were affected, 20% of whom developed acute appendicitis in childhood. The family's predisposition to acute appendicitis may be explained by environmental factors, such as certain bacterial infections, certain eating habits, or genetic differences in resistance to bacterial infection. Adamidis et al. said that low fiber intake plays an important role in the pathogenesis of acute appendicitis and also accounts for 70% of cases.

Brender et al. found in their case-controlled study, that seven patients with a history of appendicitis had siblings with the same history. Finally, they stated that these results indicate a tendency for the intestinal tract to be passed down from the family.

Genetic factors

Genetic factors play a role in the emergence of acute appendicitis. Basta et al. showed the likelihood of appendicitis was 10 times greater in children who had at least one relative who had reported appendicitis, compared to children without a family free of appendicitis. They also found that the proportion of families with appendicitis varied directly with level of association: 21% in first-degree families, 12% in second-degree families, and 7% in third-degree families. This complex sorting analysis was supported by a multiple gene model with a total heritability of 56%.

Basta et al. has supported the hypothesis that acute appendicitis is familial, as well as the possibility that the HLA system (human leukocyte antigen) and ABO blood group are related. They found that blood group A had a higher risk of developing appendicitis than group O. They also found that the Rh CcD-Ee phenotype (characteristic) was significantly more common in appendicitis patients. In this study, we can say that there is a role for inherited dual (polygenic) genes in acute appendicitis.

Conclusion

Although there has not been much progress in explaining the etiology and pathogenesis of acute appendicitis, the propensity for families to develop acute appendicitis can be explained by environmental factors such as certain bacterial infections, certain dietary habits, or genetic differences in fighting bacterial infection. However, the complex sorting analysis was supported by a multiple gene (polygenic) model with 56% heritability. This means that nearly half of the variability in acute appendicitis risk is due to genetic factors. In this study, we can say that there is a role for inherited dual genes in acute appendicitis. A positive family history of the disease increases the risk of acute appendicitis by almost 3 times.