Diazoxide: functions, dosage, side effects, how to use

Diazoxide What Medicine?

What is diazoxide for?

Diazoxide is a drug used to treat very low blood sugar levels (hypoglycemia). Certain conditions such as tumors in the pancreas, cancer, and leucine sensitivity can cause too much insulin release. Insulin is a natural substance that can lower blood sugar. This drug works by preventing the release of insulin from the pancreas, helping to restore normal blood sugar levels.

Diazoxide is a thiazide class of drugs, but does not have the diuretic effect of other thiazides. Diazoxide should not be used to treat low blood sugar for people with malnutrition.

How is diazoxide used?

Take this medication by mouth, as directed by your doctor, usually 2 to 3 times daily (every 8 to 12 hours). Your doctor may direct you to follow a diet specific to your condition. Consult your doctor, pharmacist, or nutritionist for more details.

Do not switch between the diazoxide capsule and suspension form without discussing it with your doctor first. Your dosage may need to be adjusted. If you are using this medication as a solution, shake the bottle thoroughly before taking each dose. Carefully measure the dose using a special measuring device / spoon. Don't use a household spoon as you may not get the right dose. Do not drink the medicinal solution if the color has turned dark. Just throw it away.

The dosage is based on your body weight, medical condition, and response to treatment. You need to check your blood sugar and urine levels for sugar and ketone conditions on a regular basis. Your doctor will adjust the dosage based on this test. Your doctor may regularly change your dose when you first start taking the drug to find the best dose for you. Follow your doctor's directions carefully for proper dosage and blood / urine tests.

Use this remedy regularly for optimal benefits. You need to remember to take this drug at the same time every day. Tell your doctor if your condition persists or gets worse after 2 to 3 weeks

How is diazoxide stored?

Diazoxide is a drug that should be stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Diazoxide dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of diazoxide for adults?

• For treating hypertension emergency, the dose of diazoxide is 1-3 mg / kg, every 5 -15 minutes, then every 4-24 hours by infusion. This drug must be given in less than 30 seconds into a peripheral vein. The maximum dose is 150 mg.
• To treat hypoglycemia, the dose of diazoxide is 3-8 mg / kg / day taken by mouth in divided doses every 8 or 12 hours. Higher doses (up to 15 mg / kg / day) have been used in refractory hypoglycemia.

What is the dose of diazoxide for children?

• For treating hypertension emergency in children, the diazoxide dosage is 1-3 mg / kg, every 5 -15 minutes, then every 4-24 hours by infusion. This drug must be given in less than 30 seconds into a peripheral vein. The maximum dose is 150 mg.
• To treat hypoglycemia in children, the dose of diazoxide is 3-8 mg / kg / day taken by mouth in divided doses every 8 or 12 hours. Higher doses (up to 15 mg / kg / day) have been used in refractory hypoglycemia.

In what dosage is diazoxide available?

• Capsules, ora
• Proglycem 100 mg

Diazoxide side effects

What side effects can be experienced due to diazoxide?

Mild side effects that may occur after taking diazoxide drugs are:

• Nausea
• Gag
• Stomach ache
• Loss of appetite
• Diarrhea
• Mild itching or skin rash
• Headache
• Dizzy
• Restless

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Diazoxide Drug Warnings and Cautions

What should be known before using diazoxide?

• You should not take this medication if you are allergic to diazoxide
• Have a history of heart disease or blood pressure due to certain drugs such as hydrochlorothiazide (HCTZ), HydroDIURIL, Hyzaar, Lopressor HCT, Vasoretic, Zestoretic, and others.
• Diazoxide should not be used to treat hypoglycemia caused by diet.
• To make sure diazoxide is safe for you, tell your doctor if you have a history of congestive heart failure, high blood pressure, kidney disease, gout, low levels of potassium in the blood (hypokalemia).

Is diazoxide safe for pregnant and lactating women?

Diazoxide has been categorized as pregnancy category C by the FDA. This medicine is not indicated for use during pregnancy. Animal studies have shown evidence of stunted fetal growth and fetal survival in puppies, as well as prolonged puerperium. There are no adequate or controlled data from human pregnancy studies. Diazoxide should only be used during pregnancy when it is clear what the needs are. If given during labor, diazoxide may be able to stop uterine contractions, which requires the use of an oxytocic agent.

There are no data on the excretion of diazoxide into human milk. The manufacturer recommends that because of the potential for serious side effects in a nursing infant, the decision to make is between stopping breastfeeding or stopping the drug, taking into account the importance of the drug to the mother.

Diazoxide Drug Interactions

What medicines may interact with diazoxide?

Tell your doctor about all medicines you are taking, and any medicines you have started taking or have stopped taking during treatment with diazoxide, especially:

• Diuretics (water pills)
• Blood thinners such as warfarin (Coumadin, Jantoven).

Other drugs can also interact with diazoxide, including prescription and non-prescription drugs, vitamins, and herbal products. Tell your doctor about all medicines you are using now and all medicines you have recently stopped using.

Can food or alcohol interact with diazoxide?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with diazoxide?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems.

Diazoxide overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Overdose symptoms may include extreme thirst or very dry mouth, bad breath, upset stomach, vomiting, increased urinary frequency, confusion, and high blood ketone levels.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.