Perphenazine: functions, dosage, side effects, how to use it

Functions & Usage

What is Perphenazine used for?

Perphenazine is a drug to treat certain mental / mood disorders (eg schizophrenia, manic phase bipolar disorder, schizoaffective disorder). This medicine helps you think more clearly, reduce nervousness, and be better able to perform daily activities.

Perphenazine can reduce aggressive habits and the desire to hurt yourself / others. This medication may also reduce hallucinations (eg listening / seeing things invisible to the eye). Perphenazine is a psychiatric drug (a type of antipsychotic) that works by helping to restore the balance of certain natural substances (such as dopamine) in the brain.

How do you use Perphenazine?

This medicine should be taken usually 1-3 times a day with or without food or as directed by a doctor.

Dosage is based on medical condition and response to therapy. Your doctor may order you to take a low dose initially, gradually increasing the dose to reduce the chance of side effects such as muscle spasms. Follow the doctor's instructions carefully.

When you start treatment, regular doctor visits may be necessary to find the best dosage for you. Follow all scheduled medical / lab appointments.

Take this medicine regularly for maximum benefits. To help you remember, take it at the same time each day. Although you may notice some of the drug's effects after starting it, it may take 4-6 weeks of regular use to fully benefit. Do not stop taking this medication without consulting your doctor. The condition may get worse if the medicine suddenly stops taking it. The dose may need to be decreased gradually. Tell your doctor if your condition doesn't get better or if it gets worse.

How to store Perphenazine?

Store the medicine at room temperature away from light and moisture. Do not store in the bathroom and freeze medication. Medicines under different brands may have different storage methods. Check the product box for instructions on how to store it, or ask the pharmacist. Stay away from children and pets.

It is forbidden to flush the medicine in the toilet or throw it into the drain if not told to. Properly discard this product if it is past the deadline or is no longer needed. Consult a pharmacist or local waste disposal company for more in-depth details on how to safely dispose of the product.

Precautions & Warnings

What should be considered before using Perphenazine?

Before deciding to use this drug, the risks of using the drug must be weighed against its benefits. This is a decision you and your doctor will make. For this drug, the following should be considered:

Allergy

Tell your doctor if you have had any unusual or allergic reactions to this medicine or any other medicines. Also, tell your healthcare professional if you have any other type of allergies, for example to foods, dyes, preservatives, or animals. For over-the-counter products, read labels or packaged products carefully.

Children

Certain side effects, such as muscle spasms of the face, neck and back, movements such as convulsions, inability to move the eyes, turning the body, or weakening of the arms and legs, are more common in children, who are usually more sensitive than adults against a number of side effects of the combination perphenazine and amitriptyline. The combination of perphenazine and amitriptyline should be used with caution in children with depression. Studies have shown relapse in children who think about or attempt suicide in clinical trials for this drug. More studies are needed to confirm the combination of perphenazine and amitriptyline is safe and effective in children.

Elderly

Confusion, visual disturbances, dizziness or fainting, drowsiness, dry mouth, constipation, disturbed urination, trembling hands and fingers, and symptoms of tardive dyskinesia (such as involuntary movements of the mouth, tongue, jaw, arms, and / or feet) is especially likely to appear in elderly patients. Elderly patients are usually more susceptible than adults to the effects of the combination of perphenazine and amitriptyline.

Is Perphenazine safe for pregnant and lactating women?

Pregnancy

Perphenazine has not been officially included in the category of pregnancy. Animal studies have not been reported. There are no controlled data on human pregnancy.

Breastfeeding

There are not adequate studies in women to determine infant risk when using this medicine during breastfeeding. Consider the potential benefits against the potential risks before using this medicine while breastfeeding.

Side effects

What are the possible side effects of Perphenazine?

Get emergency medical help if you experience signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

Stop using perphenazine and contact your doctor immediately if you experience serious side effects such as:

• Seizures or involuntary movements of the eyes, lips, tongue, face, arms, or legs
• Uncontrolled shaking, salivating, difficulty swallowing, impaired balance or difficulty walking
• Restless, nervous, or irritable
• Confusion, unnatural thoughts or habits
• Feel like passing out
• Convulsions
• Reduced night vision, narrowed vision, watery eyes, increased sensitivity to light
• Nausea and stomach pain, rash, and jaundice
• High fever, stiff muscles, confusion, sweating, fast or irregular heartbeat, very fast breathing
• Pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms
• Little or no urine comes out
• Muscle pain or swelling accompanied by fever, swollen glands, muscle aches, shortness of breath, vomiting, abnormal thoughts or habits, and discolored skin; or
• Slow heart rate, weak pulse, fainting, slow breathing (may stop).

Milder side effects may include:

• Dizziness, drowsiness, anxiety
• Blurry vision, headache
• Sleep disturbance (insomnia), strange dreams
• Constipation
• Dry mouth or stuffy nose
• Swollen breasts or discharge
• Menstrual cycle changes
• Weight gain, swelling of the hands or feet
• Impotence, difficulty orgasm
• Mild hives or rash

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Interactions

What drugs can interfere with the drug Perphenazine?

Using this medication with the following medicines is not recommended. Your doctor may decide not to treat you with this drug or change some of the other medicines you take.

• Amifampridine
• Bepridil
• Cisapride
• Clorgyline
• Dronedarone
• Droperidol
• Furazolidone
• Grepafloxacin
• Iproniazid
• Isocarboxazid
• Levomethadyl
• Linezolid
• Mesoridazine
• Methylene Blue
• Metoclopramide
• Moclobemide
• Nialamide
• Pargyline
• Phenelzine
• Pimozide
• Piperaquine
• Procarbazine
• Ranolazine
• Selegiline
• Sparfloxacin
• Terfenadine
• Thioridazine
• Toloxatone
• Tranylcypromine

Using this medication with the medicines below is usually not recommended, but may be needed in some cases. If the two drugs are prescribed together, your doctor may change the dose or the length of time you take one or both drugs.

• Acecainide
• Alfuzosin
• Almotriptan
• Amiodarone
• Amisulpride
• Amoxapine
• Amprenavir
• Anagrelide
• Apomorphine
• Aprindine
• Aripiprazole
• Arsenic Trioxide
• Artemether
• Asenapine
• Astemizole
• Atazanavir
• Azimilide
• Azithromycin
• Bretylium
• Brompheniramine
• Bupropion
• Buserelin
• Buspirone
• Chloral Hydrate
• Chloroquine
• Chlorpheniramine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Clonidine
• Clozapine
• Cocaine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Dasatinib
• Delamanid
• Desipramine
• Deslorelin
• Desvenlafaxine
• Dextromethorphan
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Droperidol
• Eletriptan
• Eliglustat
• Enflurane
• Epinephrine
• Erythromycin
• Escitalopram
• Eslicarbazepine Acetate
• Etylephrine
• Fentanyl
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Foscarnet
• Frovatriptan
• Gatifloxacin
• Gemifloxacin
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Halothane
• Histrelin
• Hydrocodone
• Hydromorphone
• Hydroxytryptophan
• Ibutilide
• Iloperidone
• Imipramine
• Indacaterol
• Iobenguane I 123
• Isoflurane
• Isradipine
• Ivabradine
• Ketoconazole
• Lacosamide
• Lapatinib
• Leuprolide
• Levalbuterol
• Levofloxacin
• Levomilnacipran
• Levorphanol
• Levothyroxine
• Lidoflazine
• Lithium
• Lithium Carbonate
• Lopinavir
• Lorcainide
• Lorcaserin
• Lumefantrine
• Mefloquine
• Meperidine
• Methadone
• Methoxamine
• Metrizamide
• Metronidazole
• Midodrine
• Milnacipran
• Mirtazapine
• Moricizine
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Naratriptan
• Nefazodone
• Nefopam
• Nilotinib
• Norepinephrine
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olodaterol
• Ondansetron
• Oxilofrine
• Oxycodone
• Oxymorphone
• Paliperidone
• Palonosetron
• Pazopanib
• Pentamidine
• Pentazocine
• Perflutren Lipid Microsphere
• Phenylephrine
• Pixantrone
• Posaconazole
• Procainamide
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propoxyphene
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Rasagiline
• Risperidone
• Rizatriptan
• Saquinavir
• Sematilide
• Sertindole
• Sertraline
• Sevoflurane
• Sibutramine
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Spiramycin
• Sulfamethoxazole
• Sultopride
• Sumatriptan
• Sunitinib
• Suvorexant
• Tapentadol
• Tedisamil
• Telavancin
• Telithromycin
• Tetrabenazine
• Toremifene
• Tramadol
• Trazodone
• Trifluoperazine
• Trimethoprim
• Trimipramine
• Triptorelin
• Tryptophan
• Umeclidinium
• Valproic Acid
• Vandetanib
• Vardenafil
• Vasopressin
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voriconazole
• Vortioxetine
• Ziprasidone
• Zolmitriptan
• Zotepine

Using this medication with the medicines below may increase your risk of certain side effects, but using both drugs may be the best treatment for you. If the two drugs are prescribed together, your doctor may change the dose or the length of time you take one of the two drugs.

• Acenocoumarol
• Arbutamine
• Atomoxetine
• Belladonna
• Belladonna Alkaloids
• Betel Nut
• Bethanidine
• Carbamazepine
• Cimetidine
• Diazepam
• Dicumarol
• Evening Primrose
• Fluvoxamine
• Fosphenytoin
• Galantamine
• Guanethidine
• Meperidine
• Midodrine
• Orphenadrine
• Paroxetine
• Phenprocoumon
• Phenylalanine
• Phenytoin
• Procyclidine
• Rifapentine
• Ritonavir
• S-Adenosylmethionine
• St. John's Wort
• Topiramate
• Trihexyphenidyl
• Warfarin

Can certain foods and drinks interfere with the work of the drug Perphenazine?

Certain drugs cannot be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. The following interactions have been selected on the basis of their significant potential and are not necessarily all inclusive.

Using this medication with any of the following is usually not recommended, but may not be avoided in some cases. When used together, your doctor may change the dose or length of time you use this medication, or give specific instructions about using food, alcohol, or tobacco.

• Tobacco
• Ethanol

What health conditions can interfere with the performance of the drug Perphenazine?

The presence of other medical disorders may affect the use of this drug. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcoholism - certain side effects such as heat stroke may be more frequent
• Asthma (history) or other lung disease
• Bipolar disorder (mania-depression)
• Blood disease
• Breast cancer
• Difficulty urinating
• Enlarged prostate
• Epilepsy or other seizure disorder
• Glaucoma
• Heart or blood vessel disease
• Mental illness (severe)
• Parkinson's disease
• Stomach or intestinal problems - the combination of perphenazine and amitriptyline might make the condition worse
• Kidney illness
• Liver disease - higher levels of perphenazine and amitriptyline in the blood may occur, which increases the chance of side effects
• Overactive thyroid - the combination of perphenazine and amitriptyline might increase certain serious side effects on the heart
• Reye's syndrome - the chance of unwanted effects on the liver may increase

Dose

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Perphenazine for adults?

Usual adult dosage for psychosis

For patients who are moderately disturbed, not hospitalized:

Tablets: 4-8 mg 3 times a day. The dose should be reduced as soon as possible to the minimum effective dose.

For hospitalized psychotic patients:

Tablets: 8-16 mg 2-3 times a day. Avoid excessive doses of 64 mg per day.

Concentrate: 8-16 mg 2-4 times a day. Avoid excessive doses of 64 mg per day.

Prolonged doses in excess of 24 mg per day should be reserved for inpatients or patients under continuous supervision for early detection and management of adverse reactions.

For patients requiring immediate control for whom oral administration is not feasible: 5 mg by deep IM injection. It may be repeated every 6 hours, not exceeding the daily dose of 15 mg for outpatients or 30 mg for inpatients. If necessary, an initial IM dose of 10 mg may be given for symptoms of severe psychosis.

Usual adult dose for nausea / vomiting

For severe nausea and vomiting:

Tablets: 8-16 mg daily in separate doses, up to 24 mg if necessary. The reduction in the initial dose is essential. Prolonged doses in excess of 24 mg per day should be reserved for hospitalized patients or patients under continuous supervision for early detection and management of adverse reactions.

What is the dosage of Perphenazine for children?

Usual children's dosage for psychosis

> 12 years:

For patients who are moderately disturbed, not hospitalized:

Tablets: 4 mg 3 times a day. The dose should be reduced immediately to the minimum effective dose.

For inpatients of psychosis:

Tablets: 8 mg 2 times a day.

For patients requiring immediate control or inappropriate oral administration:

5 mg by deep IM injection. Maybe repeated every 6 hours.

Usual children's dose for nausea / vomiting

> 12 years:

For severe nausea and vomiting:

Tablets: 8 mg per day in separate doses. The reduction in the initial dose is very important.

For patients requiring immediate control or inappropriate oral administration: 5 mg by deep IM injection. Maybe repeated every 6 hours.

In what dosages and preparations is Perphenazine available?

Injection: 2 g, 4 g, 8 g, 16 g

What to do in an emergency or overdose?

Overdose symptoms may include:

• Difficult to respond to the surrounding environment
• Coma (loss of consciousness over a period of time)
• Convulsions
• Fast or irregular heartbeat

In case of an emergency or overdose, contact the local emergency services provider (118/119) or immediately to the nearest hospital emergency department.

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.