Phenindione: functions, dosage, side effects, how to use it

Functions & Usage

What is Phenindione used for?

Phenindione is a drug to prevent and treat blood clots in the veins and arteries, for example, clots in the legs, lungs, brain or heart.

Phenindione belongs to a group of drugs called anticoagulants. This medicine increases the time it takes for the blood to clot.

How do you use Phenindione drugs?

Always take phenindione tablets exactly as your doctor says. Read the label on the packaging to see how many Phenindione tablets to take, and how often to take. You should ask your doctor or pharmacist if you are not sure. Adult:

• The usual starting dose is 200 mg (20 tablets) on the first day
• After the first day the dose is usually reduced to 100 mg (10 tablets) per day.

Starting from the 3rd day of treatment, the doctor will increase or decrease the dose depending on the results of blood tests that will be done at initial and regular intervals during treatment.

• Swallow the tablet whole with a glass of water
• Try to take the tablets at the same time every day
• Do not take more tablets than your doctor recommends.

This product is not suitable for use by children.

If you have to go to another doctor, hospital, or dentist, tell them that you are being treated with phenindione tablets and ask them to call your doctor themselves.

How to store Phenindione?

Store the medicine at room temperature away from light and moisture. Do not store in the bathroom and freeze medication. Medicines under different brands may have different storage methods. Check the product box for instructions on how to store it, or ask the pharmacist. Stay away from children and pets.

It is forbidden to flush the medicine in the toilet or throw it into the drain if not told to. Properly discard this product if it is past the deadline or is no longer needed. Consult a pharmacist or local waste disposal company for more in-depth details on how to safely dispose of the product.

Precautions & Warnings

What should be considered before using Phenindione drugs?

Don't take phenindione tablets if you:

• Allergy to phenindione or other ingredients in this medicine (see section 6 of this brochure)
• Experiencing liver or kidney problems
• Pregnant or trying to get pregnant
• Within the last 72 hours after having had surgery or in the last 48 hours after delivery
• Suffering from unusual bleeding or bruising
• Suffering from uncontrollable high blood pressure
• Have a tissue infection of the lining of the heart called bacterial endocarditis
• Have a rare sugar intolerance disorder
• The doctor has told you that you have bleeding inside the brain (hemorrhagic stroke).

Be careful taking phenindione tablets especially if you:

• Elderly
• Weight has recently decreased or increased dramatically
• Experiencing short-term illness
• Have kidney or liver problems that are not classified as severe
• Are sick or have diarrhea
• Moderate dietary changes that may result in reduced vitamin K
• Have a protein C or S deficiency (blood clotting disorder)
• Suffering from brain and blood vessel disease
• Suffer from severe heart disease, lack of iron levels in the blood (which may result in pale eyes and skin)
• Have been seriously injured
• Have stomach ulcers
• Bleeding in the stomach or intestines
• Thyroid hormone levels increase or decrease
• Suffering from cancer
• Reduced blood supply to the brain (ischemic stroke)
• Has quit smoking

Tell your doctor if any of the above conditions occur to you as they may change the effect of pheninidione tablets and require an adjustment of the dosage.

Is the drug Phenindione safe for pregnant and lactating women?

Ask your doctor or pharmacist for advice before taking any medication. Phenindione tablets should not be taken if you are pregnant, think you are pregnant or are planning to become pregnant. If you think you may be pregnant, contact your doctor immediately. Phenindione tablets can cause adverse effects on the fetus, and alternative medicines are available. Talk to your doctor before taking medication if you are breastfeeding.

Side effects

What are the possible Phenindione side effects?

Like other medicines, phenindione tablets can cause side effects, although not everyone experiences them. Stop using phenindione tablets and tell your doctor immediately if you experience:

• Signs of an allergic reaction include rash, hives, swollen lips, difficulty breathing
• Blood disorders (the doctor will do tests to check for them)
• Hair loss
• Diarrhea
• Jaundice
• The skin is red or black because the skin may die. In addition, the skin may be blue in color, including on the toes. This is a rare complication, most commonly occurring during the first few days of therapy with phenindione tablets, and often associated with a large initial dose
• Kidney or liver problems
• Bleeding or blood clots in the brain
• Blood clot in the chest
• Nosebleed
• Vomiting blood
• Black stool
• Nausea or vomiting
• Taste disturbances
• Fever
• Abnormal bleeding from the stomach, intestines or rectum
• Pancreatitits in the form of severe stomach or back pain
• Blood in the urine.

Other side effects may include:

• The color of urine may be pink or orange.

If side effects become serious, or you notice any side effects not listed in this brochure, tell your doctor or pharmacist.

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Interactions

What drugs can interfere with the action of the drug Phenindione?

Although certain drugs should not be used together, in other cases two different drugs may be used together even if interactions are possible. In this case, the doctor may want to change the dose, or other warnings may be important. Tell your healthcare professional if you are taking prescription or nonprescription drugs.

Can certain foods and drinks interfere with the work of Phenindione drugs?

Certain drugs cannot be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs may also cause interactions. Discuss with a healthcare professional about using drugs with food, alcohol, or tobacco.

What health conditions can interfere with the performance of the drug Phenindione?

The presence of other medical disorders may affect the use of this drug. Make sure you tell your doctor if you have any other medical problems.

Dose

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Phenindione for adults?

The usual starting dose is 200 mg (20 tablets) on the first day. After the first day the dose is usually reduced to 100 mg (10 tablets) per day.

Starting from the 3rd day of treatment, the doctor will increase or decrease the dose depending on the results of blood tests that will be done at initial and regular intervals during treatment.

What is the dosage of the drug Phenindione for children?

Safety and effectiveness have not been confirmed in pediatric patients (less than 18 years).

In what dosages and preparations is Phenindione available?

Tablets: 10 mg; 25 mg; 50 mg

What to do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (118/119) or immediately to the nearest hospital emergency department.

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.