Progesterone: functions, dosage, side effects, how to use

What drug progesterone?

What is Progesterone?

Progesterone is a hormone in women that plays an important role in regulating ovulation and menstruation.

Progesterone is a drug with the function of causing menstruation in women who have not yet menopause but who cannot menstruate due to a lack of progesterone in the body. This drug can also prevent overgrowth in the lining of the uterus in women who are menopausal and receiving estrogen hormone replacement therapy.

Progesterone can also be used for other purposes not listed in this medical guide.

Progesterone dosage and side effects of progesterone are detailed below.

How is Progesterone used?

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

Progesterone is sometimes given for short periods of time, for example 6 to 12 days at the time of the menstrual cycle. Following your dosing schedule is very important for this drug to work effectively. Try not to miss a single dose.

Take progesterone pills with a full glass of mineral water.

Apply progesterone cream to the skin as directed by your doctor.

An injection of progesterone is injected into a muscle. A doctor, nurse, or other health care provider will give this injection. You may be given instructions on how to use the injection at home. Do not use this medication at home if you do not really understand how to administer injections and how to properly dispose of needles and syringes after they are used to administer medications.

This medication may cause unexpected results on certain medical tests. Tell the doctor treating you if you are taking progesterone.

Your doctor will need to see you on a regular schedule while you are using this medicine. Don't miss a single meeting.

How is Progesterone stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Progesterone dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the Progesterone dosage for adults?

Standard adult dosage for amenorrhea:

5 to 10 mg IM for 6 to 8 consecutive days

400 mg taken by mouth for 10 days. The dose is given at night.

Standard adult dosage for uterine bleeding:

5 to 10 mg IM daily for 6 doses

Standard adult dosage for Endometrial Hyperplasia — prophylaxis:

200 mg taken by mouth for 12 consecutive days, per 28 day cycle. The dose is given at night.

Standard adult dosage for Progesterone deficiency:

Assisted Reproductive Technology (ART) - Gel:

90 mg of 8% gel, once daily vaginally, in women requiring supplementation.

90 mg of 8% gel, twice daily vaginally, in women with partial or complete ovarian failure requiring replacement.

If pregnancy occurs, vaginal treatment can be continued until the placenta is formed, 10 to 12 weeks.

Assisted Reproductive Technology (ART) - 100 mg given vaginally two or three times a day starting with oocyte collection and continuing for up to 10 weeks of total duration. Its effectiveness in women over 35 years of age is not certain. The standard dosage in this age group has not been determined.

Progesterone deficiency associated with menopause and perimenopause:

Menopause and perimenopause: progesterone 1.7% topical cream: apply approximately ¼ to ½ teaspoon on palms, heel tips, or other tender areas once or twice daily.

Standard adult dosage for preterm birth:

Study (n = 459) - National Institute of Child Health and Human Development (NICHD) - prevention of recurrent preterm birth in women at high risk: 17-alpha-hydroxyprogesterone caproate (17P) 250 mg IM once a week starting at 21 weeks of pregnancy until the time of birth or the 36th week of pregnancy.

Study (n = 142) - Reduced the incidence of sudden preterm delivery in women at increased risk: 100 mg of suppositories vaginally daily, between 24 and 34 weeks of gestation.

Standard adult dosage for convulsions:

(Study = 25) - Catamenial epilepsy: 200 mg lozenges three times daily were associated with exacerbation of convulsions during the luteal phase of the menstrual cycle. For patients with perimenstrual exacerbations, the dose is given on day 23 to day 25 of the menstrual cycle. For patients with exacerbation of convulsions during the luteal phase, the dose is given on day 15 to day 25 of each menstrual cycle. The desired serum progesterone level is between 5 and 25 mg / mL 4 hours after using lozenges. All patients continued using their anti-seizure medication.

Standard adult dosage for Perimenopausal Symptoms

Progesterone deficiency associated with menopause and perimenopause: 1.7% topical progesterone cream: rub ¼ or ½ teaspoon on palms, heels, or other soft skin parts once or twice a day.

What is the dosage of Progesterone for children?

There is no provision for the dosage of this drug for children (less than 18 years). This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is Progesterone available?

Progesterone is available in the following dosages.

100 mg capsule

Progesterone side effects

What side effects can be experienced due to Progesterone?

Seek medical help immediately if you experience an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

Stop using this drug and contact your doctor if you experience the following serious side effects:

• Sudden numbness or weakness, especially on one side of the body
• Sudden headache, confusion, eye pain, problems with vision, speech, or balance;
• The heart beats fast
• Chest pain or tightness, pain radiating to the arm or shoulder, nausea, sweating
• Unusual vaginal bleeding
• Migraine
• Nausea, stomach pain, fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
• Swelling in the hands, ankles, or feet
• Fever, chills, body aches, flu symptoms
• There is a lump in the breast
• Depressive symptoms (difficulty sleeping, weakness, mood changes).

Less serious side effects include:

• Mild nausea, diarrhea, bloating, stomach cramps
• Dizziness, spinning sensation
• Feels hot when blinking
• Mild headaches
• Joint pain
• Breast pain
• Cough
• Acne or increased hair growth; or
• The vagina feels itchy, dry, or whitish

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Progesterone Drug Warnings and Cautions

What should be known before using Progesterone?

In deciding to use this drug, the risks of using the drug must be weighed carefully with the benefits that will be obtained later. This is a decision you and your doctor will make. For this remedy, here's what you need to consider:

Allergy

Tell your doctor if you have had any different reactions or are allergic to this or any other medicine. And tell your doctor if you have certain allergies, such as to food, dyes, preservatives, or animals. For over-the-counter products, read the labels or ingredients on the packaging carefully.

Children

There is no indication for the use of progesterone in children. Safety and effectiveness have not been tested.

Elderly

To date, there are no studies that show a specific problem in geriatrics related to the limited use of progesterone in the elderly. However, elderly patients are more likely to have problems with breast cancer, stroke or dementia, requiring an adjustment in the dose for patients receiving progesterone.

Is Progesterone safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the US Food and Drug Administration (FDA). The following references the pregnancy risk categories according to the FDA:

A = No risk, B = not at risk in several studies, C = May be risky, D = There is positive evidence of risk, X = Contraindicated, N = Unknown

Breastfeeding

Studies in women have shown that this drug poses little risk to the baby when used while breastfeeding.

Progesterone Drug Interactions

What medicines may interact with Progesterone?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Using this medication with any of the following drugs is usually not recommended, but may be needed in some cases. If both drugs are prescribed together, your doctor may change the dose or the frequency with which you use one or both drugs.

• Dabrafenib
• Eslicarbazepine Acetate

Can food or alcohol interact with Progesterone?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Progesterone?

The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems, in particular:

• Abnormal vaginal bleeding
• Allergy to peanuts or peanut oil
• Blood clots (for example, deep vein thrombosis, pulmonary embolism)
• Breast cancer
• Heart attack
• Liver disease
• Stroke — Should not be used in patients with this condition
• Asthma
• Diabetes
• Edema (fluid retention or swelling in the body)
• Endometriosis
• Epilepsy
• Heart disease
• Hypercalcemia (high calcium in the blood)
• Hypercholesterolemia (high cholesterol in the blood)
• Kidney illness
• Migraine
• Systemic lupus erythematosus (SLE)
• Thyroid problems — Use with caution. Can make conditions worse.

Progesterone overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.