The 10 most deadly rare diseases in history

Colds, fever, colds, or headaches are a variety of diseases that are easy to treat, so the chances of survival are high. Unlike a number of deadly diseases that are also rare below. It is not only making shudder, because until now the modern medical world has not succeeded in finding an effective antidote or treatment for these conditions. Here's a list of the deadliest diseases in the world.

Various rare and deadly diseases in the world

1. Noma (Cancrum oris)

Noma (cancrum oris) is an infection that causes ulcers to form in the mouth or on the genitals. Boils that were previously visible to the naked eye can "move" into the body's tissues until they don't appear again, causing defects from within the body.

The hope of survival from this deadly disease is quite small. Nearly 90 percent of people who get Noma eventually die from complications of the infection. Noma generally occurs in malnourished children in areas with poor sanitation and hygiene. This infection most commonly occurs in children between 2 and 5 years of age.

2. Mycetoma (Madura Foot)

Mycetoma is a chronic skin disease that causes swelling of the legs and eventually becomes disabling. Mycetoma which is caused by a fungus (Eumycetoma) or filamentous bacteria (Actinomycetoma) it has another name " Madura foot "- eits, not from Madura in Indonesia, you know! Mycetoma first identified in Madurai, India, in the mid-19th century

Mycetoma usually appears in agricultural workers or in individuals who walk barefoot in dry and dusty conditions.

3. Complex Regional Pain Syndrome (CRPS)

CRPS is a disease that causes excruciating pain, making the sufferer experience chronic fatigue due to lack of energy. CPRS is caused by damage to the nervous system and central nervous system in the brain. The pain can be so devastating that it causes mental health problems, such as depression and anxiety disorders.

A person suffering from CRPS will feel his body burning hot and experience a sharp pain and throbbing sensation. It can also cause numbness, swelling, joint pain, and insomnia.

4. Leprosy

Leprosy is a skin infection caused by bacteria Mycobacterium leprae . Leprosy is common in Indonesia. Leprosy causes inflammation of the skin, eyes, nerves and respiratory tract which can eventually lead to loss of body parts that look terrible and vision loss.

The most common symptom of leprosy is pale colored patches on the skin that are scattered randomly and feel numb. The infected body part will be eaten away by the bacteria. Symptoms of leprosy usually appear within three to five years after exposure to the bacteria M. leprae . Some people experience no symptoms until 20 years later.

The time interval between contact with bacteria and the appearance of symptoms can be very long, making it difficult for doctors to diagnose when and where leprosy first infected. Difficulty in diagnosis is what makes treatment late, and ultimately fatal.

5. Filaria worms (Loa Loa worms)

Filarial worms are parasites that like to live in the eye and are the second leading cause of blindness worldwide. Filarial worms are not only harmful to eye health. When these worms enter other parts of the body, sufferers can experience elephantiasis. Other potential symptoms include rash, stomach pain, arthritis, and papules.

6. Vibrio vulnificus

These bacteria enter the body through raw shellfish, through open wounds, and jellyfish stings which can cause severe infections. This disease causes several symptoms including vomiting, severe diarrhea, dermatitis, and severe stomach pain.

Not only that, but Vibrio vulnificus also weakens the immune system, affects the liver and blood flow and can eventually be deadly if not treated properly. This condition occurs due to high temperatures and a decrease in salt levels on the coast which causes high levels of pathogens.

7. Pica

Pica is an eating disorder characterized by inappropriate eating behavior, namely the desire to eat things that are not actually eaten. The most common form of pica is the desire to eat any of the following: dirt, chalk, matchsticks, lint, paper, toothpaste, cigarette butts and cigarette ash, dry paint flakes, and glue.

Depending on the type of item eaten, pica can cause severe infections in the organs of the body and can be deadly. Pica usually starts in childhood and usually lasts only a few months. However, it is likely to be more difficult to treat in children with disabilities.

8.Fibrodysplasia Ossificans Progressiva (FOP)

Fibrodysplasia Ossificans Progressiva (FOP) is a disorder caused by a genetic mutation that causes muscle tissue and body connective tissue, such as tendons and ligaments, to be gradually replaced by solid bone. This abnormal bone formation outside the original skeleton will over time inhibit movement and make the sufferer look like a statue. This process generally becomes visible in early childhood, starting with the neck and shoulders, then working its way down the body and into the legs.

FOP is caused by a genetic mutation, namely the ACVR1 gene. This gene is involved in the growth and development of bones which makes them mutate more and more.

9. Clarkson's disease

Systemic capillary leak syndrome is a rare disorder characterized by leakage of plasma from the blood vessels. This causes swelling. Symptoms start from a sudden and unexplained increase in small blood vessels (capillaries). If left untreated, it can lead to organ failure and death. This condition is also called a disease Clarkson's disease .

10. Elephant man syndrome

This case originally occurred in a man from England in 1862. He experienced a change in the texture of his skin which became thickened roughly, resembling elephant skin. This rare disorder is characterized by an overgrowth of various organs and tissues of the body. The organs and tissues affected by this disorder grow disproportionately with the rest of the body.

This overgrowth affects the size difference between the right and left sides of the body. The growth pattern of this organ or excess tissue varies widely but can affect almost any part of the body.