Drotrecogin alpha: functions, dosage, side effects, how to use it

Drotrecogin Alfa What Medicine?

What is drotrecogin alpha for?

Drotrecogin alpha is a form of human protein (Protein C). This drug is generally used to treat sepsis in patients who have a high risk of death due to multisystem organ failure. Besides this drug can also be used for many benefits that are not listed in this guide.

How do you use drotrecogin alpha?

This medication is given by injection through a needle into a vein. You can get this injection in the hospital because this medicine has to be given slowly through an IV, and it can take up to 4 days to complete.

How do you store drotrecogin alpha?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.
Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Drotrecogin Alfa dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of drotrecogin alpha for adults?

Adult Dose for Sepsis

This drug was withdrawn from the market in America by manufacturers voluntarily in October 2011 because it did not succeed in providing benefits for the survival of patients with severe sepsis and septic shock. The following dosage information applies when drugs are available in the US:

24 mcg / kg / day by intravenous infusion administered for 96 hours.

What is the dose of drotrecogin alpha for children?

Children's Dose for Sepsis

This drug was withdrawn from the market in America by the manufacturer voluntarily in October 2011 because it was not successful in providing benefits for the survival of patients with severe sepsis and septic shock. The following dosage information applies when drugs are available in the US:

Some study data:

0-18 years: 24 mcg / kg / day by intravenous infusion given over 96 hours

In what dosage is drotrecogin alpha available?

Injection, lyophilized, infusion powder 5 mg, 20 mg

Drotrecogin Alfa side effects

What side effects can be experienced due to drotrecogin alfa?

Stop using this drug and seek medical help if you experience symptoms of itching allergy. hard to breath; swelling of your face, lips, tongue, or throat.

Stop using this drug and seek medical help if you experience the following serious side effects:

• there is blood in the urine or stool
• experiencing coughing up blood or vomiting that is colored like coffee grounds
• bleeding from the incision or injection marks in your skin
• bleeding that is difficult to stop

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drotrecogin Alfa Drug Warnings and Cautions

What should be known before using drotrecogin alpha?

DO NOT use this medication if:

• You are allergic to ingredients in this medicine
• You have internal bleeding or have a brain tumor
• You have had a stroke in the last 3 months
• You have recently (in the past 2 months) had brain or spinal surgery or recently suffered a serious head injury
• You have been badly injured and are at risk of severe bleeding
• You're using an epidural catheter

Contact your doctor or nurse right away if any of the things mentioned happen to you.

Is drotrecogin alpha safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

There is not yet sufficient information about the safety of using this medicine during pregnancy and breastfeeding. Always consult your doctor to weigh the potential benefits and risks before using this medication.

Drotrecogin Alfa Drug Interactions

What medicines may interact with drotrecogin alfa?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Taking this medication with the drugs below may increase your risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If these two drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them:

• anticoagulants (eg warfarin)
• glycoprotein IIb / IIIa inhibitors (eg, abciximab)
• heparin
• platelet inhibitors (for example, clopidogrel)
• salicylates (eg aspirin)
• or tissue plasminogen activator (eg, reteplase)

Can food or alcohol interact with drotrecogin alfa?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with drotrecogin alfa?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• if you are pregnant, planning to become pregnant, or are breastfeeding
• if you are taking prescription or over-the-counter medications, herbal remedies, or dietary supplements
• if you have an allergy to any type of medicine, food, or other substance
• if you have bleeding in the brain, have blood clots, have low platelet levels, have bleeding in the stomach (especially in the last 6 weeks), other bleeding problems, also if you have a high risk of bleeding, have problems with blood vessels in the brain, or a bulging blood vessel (aneurysm), for example, in the brain or stomach.
• if you have kidney or liver problems, have HIV, have recently had an organ transplant, or have ulcers
• if you have recently had an injury, had surgery, or had a stroke

Drotrecogin Alfa overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

Because Drotrecogin Alfa is given only when needed, and only by doctors and medical professional nurses, you will not miss a dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.