Estradiol: functions, dosage, side effects, how to use

Use

What is Estradiol for?

Estradiol is a female hormone drug that is used to help reduce menopausal symptoms (such as burning sensation, vaginal dryness). Menopause symptoms are caused by the body producing less estrogen.

If you are taking this medication to treat symptoms in and around the vagina only, products that are used directly inside the vagina should be considered before any medications are taken, absorbed through the skin, or injected.

Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other drugs (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. This medication should be considered prior to estrogen treatment.

Certain estrogen products can also be used to treat cancer (certain types of prostate cancer and breast cancer that have spread to other parts of the body), and by women who are unable to produce enough estrogen (for example, because of hypogonadism or primary ovarian failure).

How do you use Estradiol?

Take this medication with or without food as directed by your doctor. You can drink it with food or right after eating to prevent stomach upset.

If you are taking a slowly dissolving tablet (extended-release tablet), do not crush, chew, or dissolve the tablet as doing so can release all of the drug at the same time, increasing the risk of side effects.

Also, do not split slowly dissolving tablets, unless they have a clear dividing line or your doctor or pharmacist did not tell you to. Swallow or split the tablet without crushing or chewing.

Dosage is based on medical condition and response to treatment. Take this medicine regularly for maximum benefits.

To help you remember, take it at the same time each day as directed. Follow the dosing schedule carefully.

Do not increase your dose or take your medication more often or for longer than directed. Tell your doctor if your condition doesn't get better or if it gets worse.

How to store this drug?

Store Estradiol at room temperature away from light and moisture. Do not store in the bathroom and freeze medication.

Medicines under different brands may have different storage methods. Check the product box for instructions on how to store it, or ask the pharmacist. Stay away from children and pets.

It is forbidden to flush the medicine in the toilet or throw it into the drain if not told to. Dispose of this product properly if the medicine is past the deadline or is no longer needed.

Consult a pharmacist or local waste disposal company for more in-depth details on how to safely dispose of the medicine.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of Estradiol for adults?

The following are the recommended Estradiol dosages for adults:

Oral estradiol

• Prostate cancer: for androgen-dependent, inoperable and progressive cancer: 10 mg, 3 times daily for at least 3 months.
• Moderate to severe vasomotor symptoms associated with menopause: 1-2 mg / day adjusted as needed may be cyclic (3 weeks of drinking, 1 week of discontinuation) or continuing. Associated with progestogens in women with uterus.
• Prevention of osteoporosis in postmenopausal women: 0.5 mg / day on a cyclic basis (23 days on drink and 5 days off).
• Hypogonadism: 1-2 mg / day on a cyclic basis for 3 weeks of drinking, followed by 1 week of drug-free.

Intradiol intramuscular

• Prostate cancer: As a valerate: ≥30 mg every 1-2 weeks
• Moderate to severe vasomotor symptoms associated with menopause: as cypionate: 1-5 mg every 3-4 weeks As valerate: 10-20 mg every 4 weeks. Associated with progestogens in women with uterus.
• Hypogonadism: As a valerate: 10-20 mg every 4 weeks. As a cypionate: 1.5-2 mg monthly.

Transdermal estradiol

• Moderate to severe vasomotor symptoms associated with menopause: each patch delivers 0.025 mg / day: Initially, use once a week, adjusting dosage as needed to control symptoms. Try reducing or stopping treatment at 3-6 month intervals. Associated with progestogens in women with uterus.
• Prevention of osteoporosis in postmenopausal women: each patch delivers 14 mcg / day. Use the patch once or twice every week. Adjust dosage by monitoring biochemical markers and bone mineral density. 14 days of progestogen treatment is needed in women with a very good uterus every 6-12 months.

Vaginal estradiol

• Vulvar and vaginal atrophy: insert 2-4 g / day of vaginal cream into the vagina for 2 weeks, then slowly reduce it to half the initial dose for 2 weeks followed by the regular dose 1 g 1-3 times / week
• Postmenopausal vaginal atrophy: insert a vaginal ring containing 2 mg of estradiol and leave it for 90 days.
• Urogenital symptoms: insert a vaginal ring containing 2 mg of estradiol and leave it for 90 days.
• Atrophic vaginitis: Initial: Enter 1 tablet (20 mcg) once a day for 2 weeks. Enter 1 tablet twice a week. Try stopping or reducing the medication at 3-6 month intervals.

What is the dose of Estradiol for children?

The dosage for children has not been determined. Consult your doctor for more information.

In what dosage and preparation is this drug available?

Tablet, oral: 0.5 mg, 1 mg, 2 mg

Side effects

What are the possible side effects of Estradiol?

Like other medicines, Estradiol is a hormone drug that has the potential to cause side effects and allergic reactions.

Signs of an allergic reaction that can arise due to the hormone drug Estradiol are:

• itchy rash
• difficulty breathing
• swelling of the face, lips, tongue, or throat

Other side effects that can be caused by Estradiol are:

• Unusual vaginal bleeding (especially if you are menopausal)
• Chest pain or heaviness, pain radiating to the arm or shoulder, nausea, sweating, generally feeling unwell
• Sudden numbness or weakness, especially on one side of the body
• Sudden severe headache, confusion, problems with vision, speech, or balance
• Chest pain like stabbing, sudden coughing, sighing, breathing very fast, fast heart rate
• Pain, swelling, warmth, or redness in one or both legs
• Nausea, vomiting, loss of appetite, thirst, muscle weakness, confusion, and feeling tired or restless
• Lumps in the breast
• Feel like passing out
• Pain, swelling, or tenderness in the stomach or
• Jaundice (yellow skin or eyes).

The milder side effects of the hormone drug Estradiol are:

• Mild nausea, vomiting, bloating, stomach cramps
• Tender, tender, or swollen breasts
• Speckled or darkened facial skin
• Hair loss
• Vagina itching or discharge or
• Changes in menstrual periods, bleeding

Not everyone experiences the following side effects. There may be some side effects not listed above.

If you have concerns about certain side effects, consult your doctor or pharmacist.

Precautions & Warnings

What to know before using Estradiol?

Here are some things you need to pay attention to before using Estradiol:

• If you are allergic to any type of oral estrogen, other estrogen products, any medications, or any of the ingredients in estrogen tablets.
• If you are going to use Estradiol, tell your doctor and pharmacist that you are allergic to aspirin or tartrazine (a food coloring agent). Ask your pharmacist or check the manufacturer's patient information for a list of the inactive ingredients in the brand of estrogen tablets you plan to take.
• Prescription and nonprescription drugs, vitamins, and nutritional supplements that you are or will be taking. Your doctor may need to change the dose of your medication or watch you closely for side effects.
• If you are pregnant, planning to become pregnant, or are breastfeeding. If you become pregnant while using estrogen, contact your doctor as soon as possible.
• Talk to your doctor about the risks and benefits of using estrogen if you are 65 years or older. Older women usually should not take estrogen if they are not taking other hormones. Oral estrogen taken without other hormones is not as safe or effective as other drugs that can be used to treat the same condition.
• If you are taking estrogen to prevent osteoporosis, talk to your doctor about other ways to prevent the disease, such as exercising and taking vitamin D and / or calcium supplements.

Is Estradiol safe for pregnant or breastfeeding women?

Studies in animals or pregnant women have shown evidence of fetal abnormalities due to use of Estradiol during pregnancy. Estradiol should not be used in women who are or may become pregnant because the risks outweigh any benefit.

Studies show that this drug might change the production or composition of breast milk. If these alternatives are not prescribed, you should watch your baby for side effects and limit milk intake.

Interaction

What medicines may interact with Estradiol?

Tell your doctor about all other medicines you take, especially:

• Blood thinners or anticoagulants (warfarin)
• Cimetidine (Tagamet)
• Carbamazepine (Carbatrol, Tegretol)
• Phenobarbital (Luminal, Solfoton)
• Phenytoin (Dilantin)
• Rifampin (Rifadin, Rifater, Rifamate, Rimactane) or
• Ritonavir (Norvir)
• St. John's wort
• Antibiotics such as clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab) or
• Antifungal drugs such as ketoconazole (Extina, Ketozole, Nizoral, Xolegal).

This list is not complete and other drugs may interact with estradiol. Tell your doctor about all other medicines you use, which includes prescription drugs, over-the-counter drugs, vitamins, and herbal products. Don't start taking new medications without telling your doctor.

Can food or alcohol interact with Estradiol?

These drugs cannot be used while consuming caffeine because drug interactions can occur. Smoking tobacco or consuming alcohol with certain drugs can also cause interactions to occur.

When used together, your doctor may change your dose or how often you use this drug, or give you specific instructions about using food, alcohol, or tobacco.

What health conditions may interact with Estradiol?

The presence of other medical disorders may affect the use of this drug. Make sure you tell your doctor if you have any other medical problems.

According to Drugs.com, the following are health conditions that may interact with this drug:

• heart disease
• liver disease
• stroke
• Kidney illness
• cancer
• urinary tract infection
• asthma
• epilepsy (seizures)
• migraine
• lupus
• endometriosis or uterine fibroid tumor
• hereditary angioedema
• porphyria (enzyme disorder)
• thyroid gland disorders
• high levels of calcium in the blood (hypercalcemia)

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (119) or immediately to the nearest hospital emergency department.

Overdose symptoms may include:

• Stomach upset
• Gag
• Vaginal bleeding

What should I do if I miss a dose?

If you forget a dose of this medicine, use it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.