Methylthioninium chloride: functions, dosage, side effects, how to use

Use

What is methylthioninium chloride for?

Methylthioninium chloride is a drug used in the treatment of chronic methaemoglobinaemia, prophylaxis of oxalate urinary stone formations, and acute methaemoglobinaemia.

How is methylthioninium chloride used?

Use this product as directed. Follow all directions on the product box. If you are unsure about any information, consult your doctor or pharmacist. Tell your doctor if condition does not persist or gets worse or if new symptoms develop. If you think you may have a serious medical problem, get medical help right away.

How is methylthioninium chloride stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of methylthioninium chloride for adults?

Oral

Treatment of chronic methaemoglobinaemia

Adults: 100-300 mg per day.

Urinary tract infection

Adults: 65-130 mg tid. Maximum dose: 390 mg / day.

Prophylaxis of oxalate urinary stone formation

Adults: 65-130 mg tid. Maximum dose: 390 mg / day.

Intravenous

Acute methaemoglobinaemia

Adults: as 1% solution in a dose of 1-2 mg / kg or 25-50 mg / m2 for several minutes. Repeat dose after 1 hour if necessary. Dosages of up to 300 mg daily have been used.

What is the dosage of methylthioninium chloride for children?

Intravenous

Acute methaemoglobinaemia

Children: as 1% solution in a dose of 1-2 mg / kg or 25-50 mg / m2 for several minutes. Repeat dose after 1 hour if necessary. Doses up to 300 mg daily have been used.

In what dosage is methylthioninium chloride available?

Solution, injection: 5 mg / ml

Side effects

What side effects can be experienced due to methylthioninium chloride?

Side effects include:

• Saliva, urine, feces and skin are blue
• IV (high dose): Nausea, vomiting, stomach and chest pain, headache, dizziness, mental confusion, profuse sweating, dyspnea, hypertension, methaemoglobinaemia, hemolysis.
• Oral: GI disorders, dysuria, fever (high doses), bladder irritation.
• Intra-amniotic: Hemolytic anemia and hyperbilirubinemia in newborns.

Not everyone experiences this side effect. There may be some side effects not listed above. If you want to know about side effects, consult your doctor or pharmacist.

Precautions & Warnings

What should be known before using methylthioninium chloride?

Before using Methylthioninium chloride, tell your doctor and pharmacist:

• If you are allergic to Methylthioninium chloride or other medicines.
• The types of prescription and over-the-counter medications you are taking, including vitamins.
• If you are pregnant, planning to become pregnant, or breastfeeding. If you become pregnant while using Methylthioninium chloride, call your doctor.

Is methylthioninium chloride safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category X according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Interaction

What medicines may interact with methylthioninium chloride?

Drug interactions may change how medications work or increase the risk of serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription / over the counter medicines and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change your dose without your doctor's approval.

Can food or alcohol interact with methylthioninium chloride?

Certain drugs cannot be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Talk to your healthcare professional about using your medication with food, alcohol, or cigarettes.

What health conditions may interact with methylthioninium chloride?

The presence of other medical problems may affect the use of the drug. Make sure you tell your doctor if you have any other medical problems, especially severe kidney problems.

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms: Nausea, vomiting, precordial pain, hypertension, methaemoglobinaemia, cyanosis. Treatment: symptomatic and supportive.

What should I do if I miss a dose?

If you forget a dose of this medicine, get it as soon as possible. However, when it is near the time of the next dose, skip the missed dose and return to the usual dosing schedule. Do not double up on a dose to make up for a missed dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.