Promazine: functions, dosage, side effects, how to use

Functions & Usage

What is Promazine used for?

Promazine is a drug for the short-term treatment of moderate and severe psychomotor agitation, as well as for treating agitation or anxiety in the elderly. Promazine is used as an adjunct drug.

What are the rules for using Promazine?

Take this medicine exactly as directed by your doctor.

Use this medicine regularly for maximum benefits.

Remember to use it at the same time every day - if specifically not ordered by your doctor.

A number of certain medical conditions may require different dosage instructions according to the doctor's advice.

It is important to continue this treatment even if you feel well, if your doctor doesn't tell you to stop.

How to save Promazine?

Store the medicine at room temperature away from light and moisture. Do not store in the bathroom and freeze medication. Medicines under different brands may have different storage methods. Check the product box for instructions on how to store it, or ask the pharmacist. Stay away from children and pets.

It is forbidden to flush the medicine in the toilet or throw it into the drain if not told to. Properly discard this product if it is past the deadline or is no longer needed. Consult a pharmacist or local waste disposal company for more in-depth details on how to safely dispose of the product.

Precautions & Warnings

What should be considered before using the drug Promazine?

Acute withdrawal symptoms, including nausea, vomiting, sweating and insomnia have been described after abrupt discontinuation of antipsychotic drugs. Psychotic symptoms may also recur, and involuntary movement disorders (such as akathisia, dystonia, and dyskinesia) have been reported. Hence, slow withdrawal is recommended.

Phenothiazine should only be used with extreme caution in patients with a history of jaundice or liver dysfunction, or blood dyscrasia (perform blood tests if infection or fever occurs without cause), or heart attack.

Respiratory depression is possible in patients with severe respiratory disease.

Promazine should be used with caution in patients with renal failure.

Patients receiving phenothiazine for an extended period require regular and careful monitoring with special attention to potential eye changes (opaque cornea and lens, as well as purplish color on the skin, cornea, conjunctiva, and retina), effects on haemopoiesis, dysfunction liver, myocardia conduction effect, especially if other drugs are given simultaneously also has the potential to affect this system.

The use of phenothiazines in high doses (relative or absolute) may trigger extrapyramidal side effects, dyskinesia, akathisia, dystonia. These effects may be especially severe in children. People with Parkinson's disease should be warned. Anti-Parkinson's agents should not be prescribed routinely because of the risk of worsening anticholinergic side effects, rapidly spreading toxins or interfering with the therapeutic efficacy of the drug. They must be provided as needed.

Prolonged administration of phenothiazines may result in dyskinesia that will not improve and the likelihood of irreversibility will increase as the duration of therapy and the total cumulative dose increase. Neuroleptic therapy should be discontinued if dyskinesia develops.

Care should be given if Promazine is used to treat people with cerebral arteriosclerosis, coronary heart disease or other conditions where a drop in blood pressure may be undesirable.

Patients who have epilepsy or with conditions that affect epilepsy should be watched carefully.

Is Promazine safe for pregnant and breastfeeding women?

Do not use the drug during pregnancy, especially during the first 3 months, if there is no urgent reason.

Side effects

What are the possible side effects of Promazine?

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (eg gynecomastia and menstrual disorders), sensitivity to sunlight and hemolytic anemia.

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Drug Interactions

What drugs can interfere with the drug Promazine?

Bromocriptine: Phenothiazine reduces the effects of bromocriptine

Cisapride: increases the risk of cardiotoxicity and arrhythmias

Dexfenfluramine: reduce the effects of anorexia, may improve psychotic symptoms

Diethylpropion: reduces the effects of anorexia, may improve psychotic symptoms

Donepezil: possible antagonistic action

Fenfluramine: reduces the effects of anorexia, may improve psychotic symptoms

Galantamine: possible antagonistic action

Gatifloxacin: increases the risk of cardiotoxicity and arrhythmias

Grepafloxacin: increases the risk of cardiotoxicity and arrhythmias

Guanethidine Promazine: might reduce the effects of guanethidine

Levofloxacin: increases the risk of cardiotoxicity and arrhythmias

Mazindol: reduces the effects of anorexia, may improve psychotic symptoms

Phentermine: reduces the effects of anorexia, may improve psychotic symptoms

Phenylpropanolamine: reduces the effects of anorexia, may improve psychotic symptoms

Terfenadine: increases the risk of cardiotoxicity and arrhythmias

Can certain foods and drinks interfere with the work of the drug Promazine?

Certain drugs cannot be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss with a healthcare professional about using drugs with food, alcohol, or tobacco.

What health conditions can interfere with the performance of the drug Promazine?

Other medical problems may affect the use of this drug. Make sure you tell your doctor if you have other medical problems.

Dose

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Promazine for adults?

Psychomotor agitation

Adults: 100-200 mg, 4 times a day.

Elderly: Half the normal starting dose may be sufficient for a therapeutic response.

Agitation and restlessness

Elderly: 25 mg initially, increased if necessary, to 50 mg, 4 times daily.

What is the dosage of Promazine for children?

Promazine is not recommended for children.

In what dosages and preparations is Promazine available?

Injection, as hydrochloride: 25 mg / mL (10 mL); 50 mg / mL (1 mL, 2 mL, 10 mL)

Tablets, as hydrochloride: 25 mg, 50 mg, 100 mg

What to do in an emergency or overdose?

Ingesting large amounts of Promazine is followed by deep sleep with or without a drop in blood pressure and without any particular change in respiratory rate, in addition to an additional slowing down after sedation. Occasionally an initial period of excitement may precede a coma, followed by a grand mal seizure.

If there is no specific antidote, treatment should be based on the usual therapeutic principles with special emphasis on the following measures:

• Gastric lavage
• Treatment of seizures if they occur
• Cure for acute hypotension if necessary
• Excessive neutralizing the effects of Promazine on the central nervous system
• Control and natural recovery of hypothermia

In case of an emergency or overdose, contact the local emergency services provider (118/119) or immediately to the nearest hospital emergency department.

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.