Selegiline: functions, dosage, side effects, how to use it

What Drug Selegiline?

What is selegiline for?

Selegiline prevents damage to a chemical in your brain called dopamine. When the level of this substance is low, it can cause us to develop Parkinson's disease. Selegiline is usually used with other medicines to treat symptoms of Parkinson's disease.

Selegiline can also be used for other treatments.

How is selegiline used?

Use selegiline as prescribed to you. Do not use the drug with an amount more than the doctor recommended. Excessive doses will increase the side effects, but serious side effects can also occur. Follow the directions in your recipe.

When you are taking selegiline and 14 days after stopping, you should not consume any food that says "What should I avoid when using selegiline?" in your flyer. Eating these foods while using selegiline can raise blood pressure to dangerous levels.

The foods you MAY be able to eat are:

• meat, poultry, or fish (including lunch meat, hotdogs, sausages and ham)
• vegetables, except fava beans
• Process cheese, mozzarella, ricotta, cottage
• pizza with low-tyramine cheese
• soy milk, yogurt
• yeast

Selegiline capsules are usually taken twice a day, at breakfast and at lunch. Follow the doctor's instructions.

The crushed tablet form of selegiline (zelapar) should be taken once a day before breakfast and without any drinking.

To take Zelapar:

1. Store the tablets in the package until you are ready to take the medicine. Unpack and tear off the foil in the package. Do not push the tablet from the foil or you will damage the tablet.
2. With dry hands, remove the tablet and put it in your mouth. The tablets will thaw immediately.
3. Do not swallow the tablet whole. Crush the tablet without chewing it in your mouth. After several times it dissolves, swallow the tablet.
4. Do not drink or eat anything for at least 5 minutes after taking Zelapar.

Parkinson's disease is often treated with a combination of different drugs. The best treatment for your condition, use all medications recommended by your doctor. When you are taking selegiline, the dosage of other drugs may have to be changed. Do not change your dose or medication schedule without your doctor's advice.

Do not stop taking selegiline suddenly or you will experience dangerous side effects. For best results, keep taking the medication as prescribed by your doctor.

How is selegiline stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Selegiline dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the selegiline dosage for adults?

Adult dosage for Parkinson's disease:

Oral tablet:

Recommended dose: 5 mg orally 2 times a day

Maximum dose: 10 mg orally a day

Zelapar:

Initial dose: 1.25 mg taken once daily for at least 6 weeks. After 6 weeks, the dosage can be increased to 2.5 mg orally once a day if needed.

Development dose: 1.25mg to 2.5 mg taken daily

Maximum dose: 2.5 mg taken per day

Adult dosage for depression:

Initial dose: Take 6 mg per day inside transdermal patch and interact to the skin every 24 hours

Development dose: Use 6 mg / 24 hours or 12 mg / 24 hours transdermal patch applied to the skin once a day.

Maximum dose: 12 mg / 24 hours transdermal patch applied to the skin once a day.

What is the selegiline dosage for children?

The safety and effectiveness of the drug has not been announced by the pediatrician (less than 18 years).

In what dosage is selegiline available?

5mg capsules

Selegiline side effects

What side effects can be experienced due to selegiline?

Serious side effects generally don't occur. Stop using selegiline and call your doctor if an allergic reaction occurs (hives, difficulty breathing, closure of the throat, swelling of the lips, face, or tongue).

Stop using selegiline and call your doctor if you experience serious side effects such as:

• sudden headache, confusion, blurred vision, difficulty speaking, nausea, vomiting, chest pain, convulsions, and sudden numbness or feeling weak (especially in one part of the body)
• head feeling light, passed out
• hallucinating
• feeling restless or irritated
• muscle twitching
• pain when urinating or difficulty urinating

Less serious side effects include:

• dizziness, feeling weak
• insomnia
• runny nose
• back pain
• bowel obstruction
• mouth sores or mouth sores, pain when swallowing (when using Zelapar).

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Selegiline Drug Warnings and Cautions

What should be known before using selegiline?

Before using certain drugs, consider the risks and benefits first. This is a decision you and your doctor will have to make. For this drug, pay attention to the following:

Allergy

Tell your doctor if you have any unusual or allergic reactions to this or any other medicine. Also tell your doctor if you have any other types of allergies such as to food, coloring, preservatives, or animal allergies. For over-the-counter products, read the labels on the packaging carefully.

Children

Research on this drug has only been conducted in adults, and there is no specific information on the use of selegiline in children.

Elderly

Many drugs are not studied in the elderly. Therefore, it is not known whether this drug works the same way as adults or if it could cause different side effects or other problems if it is used in the elderly. There is no specific information on the use of selegiline in the elderly.

Is selegiline safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medicine. This drug is included in the risk of pregnancy category C according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = Not at risk
• B = No risk in several studies
• C = May be risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

Selegiline Drug Interactions

What medicines may interact with selegiline?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Using selegiline with the drugs below is not recommended. Your doctor may not recommend using this drug or changing it for another:

• Amitriptyline
• Amoxapine
• Amphetamine
• Apraclonidine
• Atomoxetine
• Benzphetamine
• Brimonidine
• Bupropion
• Carbamazepine
• Carbinoxamine
• Citalopram
• Clomipramine
• Cyclobenzaprine
• Cyproheptadine
• Desipramine
• Desvenlafaxine
• Dexfenfluramine
• Dexmethylphenidate
• Dextroamphetamine
• Dextromethorphan
• Diethylpropion
• Doxylamine
• Duloxetine
• Ephedrine
• Escitalopram
• Fenfluramine
• Fluoxetine
• Fluvoxamine
• Furazolidone
• Guanadrel
• Guanethidine
• Hydroxytryptophan
• Imipramine
• Iproniazid
• Isocarboxazid
• Isometheptene
• Levomethadyl
• Levomilnacipran
• Linezolid
• Lisdexamfetamine
• Maprotiline
• Mazindol
• Meperidine
• Methadone
• Methamphetamine
• Methotrimeprazine
• Methyldopa
• Methylene Blue
• Methylphenidate
• Milnacipran
• Mirtazapine
• Moclobemide
• Nefopam
• Nialamide
• Nortriptyline
• Opipramol
• Paroxetine
• Phendimetrazine
• Phenelzine
• Phenmetrazine
• Phentermine
• Phenylalanine
• Phenylephrine
• Phenylpropanolamine
• Procarbazine
• Propoxyphene
• Protriptyline
• Pseudoephedrine
• Rasagiline
• Reserpine
• Selegiline
• Sertraline
• Sibutramine
• St. John's Wort
• Sumatriptan
• Tapentadol
• Tetrabenazine
• Tramadol
• Tranylcypromine
• Trazodone
• Trimipramine
• Tryptophan
• Venlafaxine
• Vilazodone
• Vortioxetine

The use of selegiline with the following drugs is not usually recommended, but is needed in some cases. If both of these drugs are listed together in your prescription, your doctor may change the dose or intensity of use of one or both drugs.

• Albuterol
• Alizapride
• Altretamine
• Amineptine
• Amisulpride
• Amitriptylinoxide
• Arformoterol
• Avocado
• Bambuterol
• Bitter Orange
• Bromocriptine
• Bromperidol
• Buspirone
• Clenbuterol
• Clovoxamine
• Colterol
• Dibenzepin
• Difenoxin
• Diphenoxylate
• Dolasetron
• Domperidone
• Dothiepin
• Doxepin
• Droperidol
• Ethchlorvynol
• Femoxetine
• Phenoterol
• Fentanyl
• Fluspirilene
• Formoterol
• Frovatriptan
• Granisetron
• Guarana
• Haloperidol
• Hexoprenaline
• Hydrocodone
• Hydromorphone
• Indacaterol
• Iobenguane I 123
• Isoetharine
• Kava
• Levalbuterol
• Licorice
• Lofepramine
• Lorcaserin
• Ma Huang
• Mate
• Melitracen
• Mephentermine
• Metaproterenol
• Metaraminol
• Metoclopramide
• Metopimazine
• Morphine
• Morphine Sulfate Liposome
• Naratriptan
• Nefazodone
• Nilotinib
• Olodaterol
• Oxycodone
• Palonosetron
• Penfluridol
• Pentazocine
• Pimozide
• Pirbuterol
• Procaterol
• Reboxetine
• Reproterol
• Ritodrine
• Salmeterol
• Sulpiride
• Sultopride
• Terbutaline
• Tianeptine
• Tiapride
• Tretoquinol
• Tulobuterol
• Tyrosine
• Veralipride
• Vilanterol

Using selegiline with the drugs below may increase your risk of side effects, but using both may be the best treatment for you. If both of these drugs are listed together in your prescription, your doctor may change the dose or intensity of use of one or both drugs.

• Acarbose
• Acetohexamide
• Benfluorex
• Chlorpropamide
• Desogestrel
• Dienogest
• Dopamine
• Drospirenone
• Estradiol Cypionate
• Estradiol Valerate
• Ethinyl Estradiol
• Ethynodiol Diacetate
• Etonogestrel
• Ginseng
• Gliclazide
• Glimepiride
• Glipizide
• Gliquidone
• Glyburide
• Guar Gum
• Insulin
• Aspart Insulin, Recombinant
• Degludec Insulin
• Insulin Detemir
• Insulin Glargine, Recombinant
• Glulisine Insulin
• Human Regular Insulin
• Lyspro Insulin, Recombinant
• Levonorgestrel
• Medroxyprogesterone Acetate
• Mestranol
• Metformin
• Miglitol
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Repaglinide
• Tolazamide
• Tolbutamide
• Troglitazone

Can food or alcohol interact with selegiline?

Certain drugs should not be used with meals or at certain foods because they can cause drug interactions. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your drug use related to food, alcohol, or tobacco with your health care provider.

The use of selegiline is not recommended with the products below, but is sometimes inseparable in some cases. If used concurrently, your doctor may have changed the dose, or changed the time you take the drug, or give specific instructions about food, alcohol, or tobacco.

• Foods containing tyramine.

What health conditions can interact with selegiline?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• dyskinesia (abnormal muscle movements)
• hypertension (high blood pressure)
• mental disorders
• postural hypotension (dizziness, lightheadedness, or fainting when you wake up from sleep or in a sitting position) - use with caution because it can make the situation worse
• recurrent kidney disease — usually the use of drugs in this condition is not recommended
• liver disease - use with caution. High blood pressure due to selegiline can occur, and can increase the risk of side effects
• phenylketonuria (PKU) - crushed tablets containing phenylalanine, which can worsen this condition.

Selegiline overdose

What should I do in an emergency or overdose?

In case of emergency or overdose, contact your local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of an overdose include:

• drowsiness
• dizzy
• passed out
• disturbed
• Hyperactive
• restless
• headache
• hallucinations
• stiff jaw
• stiff back
• coma
• fast and irregular heartbeat
• chest pain
• breath slows down
• sweating
• fever
• cool skin

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.