Sevoflurane: functions, dosage, side effects, how to use

Sevoflurane What Medicine?

What is sevoflurane for?

Sevoflurane is an anesthetic. It works by suppressing activity in the central nervous system, leading to loss of consciousness. Causes general or general anesthesia (loss of consciousness) before and during surgery.

How is sevoflurane used?

Use Sevoflurane as directed by your doctor. Check the label on the medicine for precise dosing instructions. Sevoflurane is usually given by a doctor or other health care provider during surgery. If you miss a dose of Sevoflurane, contact your doctor immediately.

Ask your doctor any questions you have about how to use Sevoflurane.

How is sevoflurane stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Sevoflurane dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the sevoflurane dosage for adults?

12-25 years

2.6% in oxygen or 1.4% with 65% N2O / 35% oxygen

25-40 years

2.1% in oxygen or 1.1% with 65% N2O / 35% oxygen

40-60 years

1.7% in oxygen or 0.9% with 65% N2O / 35% oxygen

60-80 years

1.4% in oxygen or 0.7% with 65% N2O / 35% oxygen

reference.medscape.com/drug/ultane-sojourn-Sevoflurane-343101

What is the sevoflurane dosage for children?

0-1 month full term neonate

3.3% in oxygen

1-6 months

3% in oxygen

6 months <3 years

2.8% in oxygen or 2% with 65% N2O / 35% oxygen

3-12 years

2.5% in oxygen or 2.5% with 65% N2O / 35% oxygen

12-25 years

2.6% in oxygen or 1.4% with 65% N2O / 35% oxygen

reference.medscape.com/drug/ultane-sojourn-Sevoflurane-343101

In what dosage is sevoflurane available?

250mL inhalation

Sevoflurane side effects

What side effects can be experienced due to sevoflurane?

All drugs can cause side effects, but many people have no, or few, side effects. Check with your doctor if you experience the following COMMON side effects: anxiety; dizzy; drowsiness; increased cough; increased salivation; the head feels light; nausea; trembling; gag.

Seek medical help immediately if you experience any serious side effects such as a severe allergic reaction (rash; hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue); chills; fast, slow, or irregular heartbeat; fever; seizures; unusual changes in the amount or urine; yellowing of the skin or eyes.

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Sevoflurane Drug Warnings and Cautions

What should be known before using sevoflurane?

Several medical conditions can interact with Sevoflurane. Tell your doctor or pharmacist if you have any medical conditions, especially if you experience any of the following:

• if you are pregnant, planning to become pregnant, or are breastfeeding
• if you are taking prescription or nonprescription drugs, herbal preparations, or dietary supplements
• if you have an allergy to drugs, food, or other substances
• if you have liver or kidney problems or seizures

Some DRUGS MAY INTERACT with Sevoflurane. Tell your doctor if you are taking other medicines, especially any of the following: Amiodarone, droxidopa, or labetalol because side effects, such as an increased risk of low or high blood pressure and other heart complications, can occur.

Is sevoflurane safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Sevoflurane Drug Interactions

What medicines may interact with sevoflurane?

Although some drugs should not be taken at the same time, in other cases some drugs can also be used together even though interactions may occur. In such cases, the doctor may change the dose, or take other preventive measures as needed. Tell your doctor if you are taking any other over-the-counter or prescription drugs.

Taking this drug with any of the following medicines is not recommended. Your doctor may not prescribe this drug to you or will replace some of the drugs you are already taking.

• Amifampridine
• Bepridil
• Cisapride
• Dronedarone
• Mesoridazine
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Alfuzosin
• Amiodarone
• Amitriptyline
• Anagrelide
• Apomorphine
• Aripiprazole
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bedaquiline
• Buserelin
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Clozapine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Dasatinib
• Delamanid
• Desipramine
• Deslorelin
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Doxepin
• Droperidol
• Ebastine
• Eribulin
• Erythromycin
• Escitalopram
• Famotidine
• Felbamate
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Formoterol
• Foscarnet
• Fosphenytoin
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydromorphone
• Hydroquinidine
• Ibutilide
• Iloperidone
• Imipramine
• Itraconazole
• Ivabradine
• Ketoconazole
• Lapatinib
• Leuprolide
• Levofloxacin
• Lumefantrine
• Mefloquine
• Methadone
• Metronidazole
• Mifepristone
• Mizolastine
• Moxifloxacin
• Nafarelin
• Nilotinib
• Nitrous Oxide
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Paliperidone
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Perflutren Lipid Microsphere
• Perphenazine
• Posaconazole
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Rilpivirine
• Risperidone
• Ritonavir
• Sertindole
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• St. John's Wort
• Sunitinib
• Tacrolimus
• Tamoxifen
• Telaprevir
• Telavancin
• Telithromycin
• Tetrabenazine
• Tizanidine
• Tolterodine
• Toremifene
• Trazodone
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voriconazole
• Vorinostat

Taking this medication with the drugs below may increase your risk of side effects, but in some cases, a combination of these two drugs may be the best treatment. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Alcuronium
• Atracurium
• Doxacurium
• Metocurine
• Mivacurium
• Pancuronium
• Pipecuronium
• Rocuronium
• Tubocurarine
• Vecuronium

Can food or alcohol interact with sevoflurane?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with sevoflurane?

Other health conditions you have may affect the use of this drug. Make sure that you tell your doctor if you have any other health problems, especially:

• diseases that can cause muscle weakness, such as periodic familial paralysis, muscular dystrophy, myasthenia gravis, or myasthenia syndrome - muscle weakness may increase
• head injury - Sevoflurane can make this condition worse
• kidney disease - Sevoflurane can make this condition worse
• liver disease - side effects of Sevoflurane may increase
• malignant hypertemia, during or immediately after receiving anesthetic (history, or family history) side effects - it may happen again
• Portwine stain - Sevoflurane can interfere with laser treatment to remove portwine stains

Sevoflurane overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.