Antideoxyrobonuclease

Definition

What is an antideoxyrobonuclease-b titer?

This test is used to determine the presence of a Streptococcus infection.

Group A Streptococcus infection can be identified through several complications such as rheumatic fever, scarlet fever, glomerulonephritis. This test is generally used to look for Streptococcus infections (such as strep throat, pyoderma, pneumonia) caused by Streptococcus disease after infection. Disease that occurs after infection occurs at an advanced stage of infection and usually shows no symptoms during the incubation period.

Streptococcus produces an extracellular enzyme, streptolysin O, which can dissolve blood. Streptolysin O has the ability to stimulate ASO antigens. ASO is present in serum after 1 week to 1 month after Streptococcus infection. The titers of these antibodies are not used specifically to indicate any disease after infection, but to determine if you have a Streptococcus infection.

Like ASO antibody titres, IDA is also used to identify if you have been infected with Streptococcus. Although there is an ADB test that is more sensitive than ASO, doctors rarely use a single test to assess for ADB Streptococcus infection because results usually vary.

The Streptozyme test can determine the type of antibody surface antigen of group A Streptococci, such as anti-streptolysin O, anti-streptokinase and anti-hyaluronidase. About 80% of the samples were positive for anti-streptolysin with Streptozyme O, and 10% on anti-streptokinase or anti-hyaluronidase. 10% were caused by ADB antibodies or other Streptococcal extracellular antibodies.

Group B Streptococcus antigen accumulates in CSF, serum or urine. The antigen can help in determining the microbial antigen. This antigen can be associated with acute infection and is not associated with disease after the Streptococcus infection above.

To confirm a diagnosis of Streptococcus, you must be isolated.

When should I take an antideoxyrobonuclease-b titer?

This test is usually recommended if your doctor suspects you have Streptococcus and fever or kidney problems (glomerulonephritis) caused by these bacterial infections.

The anti-DNase B test and serologic test are used for antibodies to other streptococci, such as the enzyme hyaluronidase antibody test, which can be used if the ASO test result is negative when identifying whether Streptococcus has occurred before.

Rheumatic fever symptoms:

• fever
• swelling and pain in more than one joint, such as the ankles, knees, elbows and wrists. Sometimes it moves from one joint to another
• painless, small nodules under the skin.
• jolt movement (Syndenham's chorea)
• rash
• sometimes there is swelling of the heart (pericarditis), this situation may have no symptoms but can cause shortness of breath, palpitations or chest pain.

Other symptoms of glomerulonephritis:

• fatigue
• decreased amount of urine
• bleeding on urination
• edema
• hypertension

It should be noted that these symptoms can be found in other conditions.

Precautions & warnings

What should I know before taking antideoxyrobonuclease-b titer?

Beta-lipoprotein levels can increase the inhibition of Streptolysin O and cause a false increase in ASO titres.

Adrenocorticosteroids and antibiotics are drugs that can reduce the amount of ASO.

If there is an increase in the ASO level in the blood, it is not necessary to continue the Anti-DNase B test. However, if the ASO test result is negative, Anti-DNase B can be used to determine Streptococcus in people who do not produce ASO or have low ASO levels.

It is important that you understand the above warnings before running this test. If you have any questions, consult your doctor for further information and instructions.

Process

What should I do before taking antideoxyrobonuclease-b titer?

Things that need to be considered before undergoing the test:

• pay attention to the doctor's explanation of the test process.
• fasting before the test is usually not necessary

How does the antideoxyrobonuclease-b titer process?

The medical personnel in charge of drawing your blood will take the following steps:

• wrap an elastic belt around your upper arm to stop blood flow. This makes the blood vessel under the bundle enlarge making it easier to insert the needle into the vessel
• clean the area to be injected with alcohol
• inject a needle into a vein. More than one needle may be required.
• Insert the tube into the syringe to fill it with blood
• untie the knot from your arm when enough blood is drawn
• sticking gauze or cotton on the injection site, after the injection is complete
• apply pressure to the area and then put a bandage on

The doctor will store the blood sample in a tube with a red cap.

What should I do after taking a b-titer antideoxyrobonuclease?

While you generally won't feel any pain, some people can feel pain when a new needle is injected. However, when the needle is in the blood vessel, the pain is usually not felt. Pain depends on the skills of the nurse, the condition of the blood vessels, and your sensitivity to pain.

After the blood draw, it is recommended that you wrap it with a bandage and apply light pressure to your vein to stop the bleeding. You can do your normal activities after the test.

If you have any questions about this test process, please consult with your doctor to understand more.

Explanation of the Test Results

What do my test results mean?

Normal result:

Antistreptolysin O Titer:

• adults: ≤ 160 Todd units / mL
• baby: same as the mother's results
• children 6 months - 2 years: ≤ 60 Todd units / mL
• children 2 - 4 years: ≤ 160 Todd units / mL
• children 5 - 12 years: 170-330 Todd units / mL

Antideoxyribonuclease-B Titre:

• adults: ≤85 Todd units / mL or below 1:85 titer
• preschool children: ≤60 Todd units / mL or less than 1:60 titer
• school-age children: ≤170 Todd units / mL or less than 1: 170 titers

• Streptozyme: titer less than 1: 100
• Group B Streptococcus antigen: not found.

Abnormal results:

Improvements to:

• streptococcus infection
• rheumatic fever
• acute glomerulonephritis
• endocarditis infection
• scarlet fever
• Acute streptococcal pyoderma

Test results may vary depending on the laboratory. Consult your doctor if you have questions about test results.