Tiotixene: functions, dosage, side effects, how to use

What Drug Tiotixene?

What is the drug Tiotixene used for?

Thiothixene is a medication to treat psychotic symptoms. This drug belongs to the class of antipsychotic drugs from the thioxanthene series. Thiothixene shares certain chemical and pharmacological properties with the piperazine phenothiazines and is different from the aliphatic group of phenothiazines.

How do you use Tiotixene?

Follow the medication instructions given by your doctor or pharmacist before you start using this medicine. If you have questions, ask your doctor or pharmacist.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How to store Tiotixene?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Tiotixene dosage

What should be considered before using the drug Tiotixene?

The risks of using this drug must be weighed against its benefits. Consult your doctor before using this medication.

Is Tiotixene safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication.

Tiotixene side effects

What are the possible side effects of Tiotixene?

Some of the side effects you may have while using Thiothixene:

• Cardiovascular effects

Tachycardia, hypotension, dizziness and syncope. In case of hypotension, epinephrine should not be used as a pressor agent because a further drop in blood pressure can paradoxically occur. Specific ECG changes have been observed in some patients receiving thiothixene. These changes are usually reversible and often disappear with continued thiothixene therapy. The incidence of these changes is lower than that observed with some phenothiazines. The clinical significance of these changes is unknown.

• CNS effect

Drowsiness, usually mild, may occur although it usually relieves with continuation of thiothixene therapy. The incidence of sedation appeared similar to that of the piperazine group of phenothiazines but less than that of certain aliphatic phenothiazines. Restlessness, agitation and insomnia have occurred with the use of thiothixene. Seizures and paradoxical exacerbations of psychotic symptoms have occurred with rare thiothixene use.

Hyperreflexia has been reported in babies born to mothers who received structurally related drugs.

In addition, phenothiazine derivatives have been associated with cerebral edema and cerebrospinal fluid abnormalities.

Extrapyramidal symptoms, such as pseudoparkinsonism, akathisia and dystonia have been reported. Management of extrapyramidal symptoms depends on the type and severity. Rapid relief from acute symptoms may require the use of injections of anti-Parkinson's agents. Slower-appearing symptoms can be managed by reducing the dose of thiothixene and / or administering oral anti-Parkinson's agents.

• Dystonia

Class effect: Symptoms of dystonia, prolonged abnormal contractions of a group of muscles, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes causing tightness of the throat, difficulty swallowing, difficulty breathing, and / or a protrusion on the tongue. Because these symptoms can occur at low doses they also occur more frequently and are more severe with high potency with the use of high doses of first generation antipsychotic drugs. An increased risk of acute dystonia was observed in men and younger age groups.

• Persistent Dyskinesia Tardive

Like all other antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may occur after drug therapy has been discontinued. This syndrome is characterized by rhythmic involuntary movements of the tongue, face, mouth or jaw (eg, protrusion of the tongue, puffing of the cheeks, wrinkling of the mouth, chewing movements). Sometimes it can be accompanied by involuntary movements of the extremities.

Because early detection of tardive dyskinesia is important, the patient must be monitored closely. It has been reported that gentle vermicular movement of the tongue may be an early sign of this syndrome. If these or other signs of the syndrome appear, the healthcare professional should consider stopping the antipsychotic medication. (See WARNING.)

• Heart effect

High levels of serum transaminase and alkaline phosphatase, usually transient, and rarely observed in some patients. No confirmed cases by health professionals of thiothixene-induced jaundice have been reported.

• Hematological effect

As with certain other psychotropic drugs, leukopenia and leukocytosis which are usually temporary, can occur occasionally with the use of thiothixene. Other antipsychotic drugs have been associated with agranulocytosis, eosinophilia, hemolytic anemia, thrombocytopenia and pancytopenia.

• Allergic reactions

Rash, pruritus, urticaria, photosensitivity, and rare cases of anaphylaxis have been reported with the use of thiothixene. Nonessential sun exposure should be avoided. Despite inexperience with thiothixene, exfoliative dermatitis and contact dermatitis (in nursing personnel) have been reported with the use of certain phenothiazines.

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Tiotixene Drug Warnings and Cautions

What drugs can interfere with the drug Tiotixene?

Although certain drugs should not be used at the same time, in other cases two different drugs can be used together even if interactions are possible. In this case, your doctor may be able to change the dose or take other precautions that may be needed. Tell your health care professional if you are taking any other prescription or nonprescription drugs on the market

Can certain foods and drinks interfere with the drug Tiotixene?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interfere with the performance of the drug Tiotixene?

The presence of other health problems in your body may affect the use of this medicine. Tell your doctor if you have other health problems.

Tiotixene Drug Interactions

The information provided is not a substitute for a doctor's prescription. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage of Tiotixene for adults?

In mild conditions, the initial dose is 2 mg three times a day. If indicated, increasing the dose to 15 mg / day to the total daily dose is often effective.

In more severe conditions, the initial dose is 5 mg twice daily.

The usual optimal dose is 20-30 mg daily. If indicated, increasing the dose to 60 mg / day to the total daily dose is often effective. An increase of more than 60 mg rarely provides a beneficial response.

What is the dosage of the drug Tiotixene for children?

Safety and effectiveness are not known in pediatric patients (less than 18 years).

In what dosages and preparations is Tiotixene available?

Capsules 1 mg, 2 mg, 5 mg, 10 mg

What to do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (118/119) or immediately to the nearest hospital emergency department.

Overdose symptoms may include: CNS depression, stiffness, weakness, torticollis, tremors, increased salivation, dysphagia, hypotension, gait disturbances, or coma.

What should I do if I forget to take medicine or forget to take medicine?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical consultation, diagnosis or treatment.