Brugada syndrome & bull; hello healthy

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Definition

What is Brugada Syndrome?

Brugada syndrome (BrS) is one of the causes of cardiac arrest (cardiac arrest) due to ventricular fibrillation in patients who do not have structural heart disease and do not have risk factors for heart disease, such as smoking, diabetes. and obesity. This condition is an inherited genetic disease that presents as an arrhythmic syndrome.

How common is Brugada syndrome?

Brugada syndrome was more common in men than women, 9 times higher in one analysis (10: 1 ratio). Men had a higher rate of syncope and sudden death in a prospective study, 3 symptoms first appearing around age 22-65 years. The cause is still not clearly known, but this condition can be caused by the predominance of men in autosomal dominant disorders.

Therefore, this condition is classified as a disorder involving young adult males, probably most predominantly in males immigrating from Southeast Asia, mean age 40, 41 years.

This condition often appears at night (resembling a nocturnal hypoglycemic episode) and / or after consuming alcohol. Sometimes this condition can also appear suddenly and worsen causing death during the stochastic daytime frame: working, having fun, or even eating.

BrS is rarely diagnosed in children, but it can occur in patients of any age.

Brugada syndrome in children:

Many studies on the clinical features of BrS in children have been illustrated, at 13 referral centers in Europe. The findings suggest the conclusion: “In children clinical manifestations of BrS and arrhythmic events are rare but arrhythmias are more likely to occur during febrile episodes. Potential causes for delayed presentation include the impact of hormones and progressive structural degradation of myocytes (M cells)."

In a 2007 population study of 30 children (<16 years), it was shown that in children and infants who had BrS from 26 families, fever was a major precipitating factor for arrhytimic cardiac events, including syncope and SCD. Due to data limitations, the optimal steps for treating children with BrS are still unknown.

Brugada syndrome can be treated by reducing risk factors. Talk to your doctor for more information.

Signs & symptoms

What are the signs and symptoms of Brugada syndrome?

Symptoms of BrS are often thought to mimic episodes of polymorphic ventricular tachyarrhythmias without prognosis:

• Fatigue
• Dyspnea
• Restless
• Irregular heartbeat (sudden cardiac arrest or ventricular arrhythmias - most significant)
• Chest pain, heavy chest, shortness of breath
• Passion or syncope
• Stroke

The above are some of the conditions that often occur due to PhD, clinical manifestations of BrS, contributed by many factors, such as:

• Right ventricular disorders (such as bundle block, left axis deviation (LAD).)
• Mutations in the cardiac sodium channel gene SCN5A cause dispersion of repolarization in the ventricular wall, most notably in the right ventricle, causing a transmural voltage gradient that is "loss of function" of sodium channel blockers to expose ECG changes / symptoms on the electrocardiogram as ST segment elevation. However, the differences in clinical manifestations may be due to electrophysiological abnormalities caused by specific mutations associated with “overlap” symptoms.
• Autonomic dysfunction (tone)
• Use of cocaine and psychotropic drugs.

There may be signs and symptoms not listed above. If you have concerns about a particular symptom, consult your doctor.

When should I see a doctor?

You should call your doctor if you experience any of the following symptoms:

• Have a family member who has SCD, syncope or is diagnosed with ventricular tachycardia. VT / ventricular fibrillation / atrial fibrillation AF (only accounts for 20% of evidence showing an increase in cases)
• Using drugs that increase the ST segment, such as procainamide, flecainide
• Fainting, arrhythmia on previous episodes of restlessness or fever
• Born in a third world country in Asia.

If you have any signs or symptoms above or any other questions, please consult your doctor. Everyone's body is different. Always consult a doctor to treat your health condition.

Cause

What causes Brugada syndrome?

Until now researchers have found several causes associated with mutations, but due to variations and as yet undiscovered, the etiology is described as follows:

Additional derivatives of autosomal loci account for 25% of diseases such as the Malfunction Cardiac calcium channel gene, mutations in loci (SCN5A) on chromosome 3p22-25 and others in genes that transcribe sodium channels.

Reduced sodium channels in myocyte membranes have been identified as familial with BS, leading to less sodium channel concentrations and early repolarization of M cell membranes.

Risk factors

What increases my risk for Brugada syndrome?

A male patient with a family history of SCD was identified as a risk factor for the following SCD associated with BrS. Approximately 40 years old.

Risk stratification usually begins with determining the presence / absence of the associated symptoms:

• Sudden cardiac arrest (SDA) or syncope without cause
• Fever that triggers / plays a role in increasing episodes of ventricular tachycardia (VT) or ongoing arrhythmias in Brugada patients, and other serious complications
• History of asymptomatic dysfunction (high risk of atrial and / or ventricular fibrillation - “overlap” syndrome)
• Abuse of cocaine, psychotropic drugs

Medicines & Medicines

The information provided is not a substitute for medical advice. ALWAYS consult your doctor.

How is Brugada Syndrome diagnosed?

• Patients who have had previous syncope should undergo a typical ECG
• Detection of other clinical features (history of SCA, persistent ventricular tachy-arrhythmia or syncope with no apparent cause)
• Ultrasonic (echocardiogram), MRI, myocyte biopsy unspecified
• Genetic testing is promising.

What are the treatments for Brugada syndrome?

BrS can be resolved by indicating implantable cardioverter-defibrillator therapy. Although treatments have been tried - the drugs, quinine and hydroquinine, may benefit patients with BS, it has been concluded that amiodarone and beta-blockers do NOT protect BrS patients against SCD.

The ICD is the most efficient method. However, implantation of the ICD carries several risks, including a high rate of shock during a normal rhythm and causing pain.

Small research has shown quidinine reduces the risk of recurrent ventricular tachyarrhythmias and is being studied further.

Home remedies

What are some lifestyle changes or home remedies that can be done to treat Brugada syndrome?

Brugada syndrome is an inherited disease, so there's nothing you can do to prevent it. Here are the lifestyle and home remedies that can help you deal with Brugada syndrome:

• Patients with abnormal heart structure and function should be diagnosed with clinical features, especially ECG to eliminate the high risk of Brugada symptoms and further complications.
• Patients with BrS should be monitored and treated with an ICD. The study's mortality ratio in patients with ICD to 0% after 10 years increases the likelihood of surviving and preventing SCD in patients.

If you have any questions, consult your doctor for the best solution to your problem.