Daunorubicin: functions, dosage, side effects, how to use

Daunorubicin What Medicine?

What is Daunorubicin for?

Daunorubicin is a cancer drug that is often used to treat leukemia and other cancers.

Daunorubicin is a drug that belongs to the anthracyclines class of drugs. These drugs work by slowing or stopping the growth of cancer cells.

How to use Daunorubicin?

This medicine is given by injection into a vein by a health care professional. Dosage is based on your medical condition, body size, and response to treatment.

If this medicine comes in contact with your skin, immediately wash the area with soap and water. If this medicine touches your eyes, open your eyelids and flush with water for 15 minutes, then get medical help right away. Your nurse should take precautions (for example, wear gloves) to prevent contact with patient urine and other bodily fluids.

Drink plenty of fluids while using this medication, unless directed by your doctor otherwise. Drinking plenty of water can help reduce the risk of certain side effects (for example, increased uric acid).

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How to store Daunorubicin?

Daunorobicin is a drug that should be stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Daunorubicin dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for Daunorubicin for adults?

To treat acute leukemia, the dosage of daunorubicin is 45 mg / m2 / day which is given by infusion of 2 to 5 minutes once a day on days 1, 2, and 3 for first use.

What is the dosage of Daunorubicin for children?

To treat leukemia in children, the dosage of daunorubicin is 30 to 60 mg / m2 / which is given intravenously on a 1 to 3 day cycle. Or 20 mg / m2 / day for 4 days every 14 days.

In what dosage is Daunorubicin available?

The available dosages of Daunorubicin are:

• Infusion injection 5 mg / mL (4 mL, 10 mL)
• Liquid dissolved by infusion of 20 mg (cerubidine)

Daunorubicin side effects

What side effects can be experienced due to daunorubicin?

Common side effects of the drug Daunorubicin are

• Nausea
• Gag
• Diarrhea
• Constipation
• Decreased appetite
• Hair loss

In addition, this drug can also cause urine to be reddish in color. This condition is harmless and should not be confused with blood in the urine. Temporary hair loss is a common side effect. Normal hair growth can return after treatment has ended.

Not everyone experiences this side effect. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Daunorubicin Drug Warnings and Cautions

What should be known before using Daunorubicin?

Some things you should know before taking Daunorubicin are:

• Tell your doctor and pharmacist if you are allergic to this drug, any other medications, or any of the ingredients in Daunorubicin injections. Ask your pharmacist for a list of the ingredients that make up the drug.
• Tell your doctor and pharmacist about prescription and nonprescription drugs, vitamins, nutritional supplements, and herbal products that you are using or will be using. Be sure to mention the following: drugs listed in the IMPORTANT WARNING section and one of the following: azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex, Trexall), sirolimus (Rapamune), and tacrolimus (Prograf). Your doctor may need to change the dose of your medication or monitor you carefully for side effects. Other drugs can also interact with Daunorubicin, so be sure to tell your doctor about all medications you use, even those that don't appear on this list.
• Tell your doctor if you have or have ever had any other medical conditions.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not get pregnant while you are using Daunorubicin. If you become pregnant while receiving Daunorubicin, contact your doctor. Daunorubicin can harm the fetus.

Is Daunorubicin safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category D according to the US Food and Drug Administration (FDA) United States, or the equivalent of the POM in Indonesia.

The following references the pregnancy risk categories according to the FDA:

• A = Not at risk
• B = No risk in several studies
• C = May be risky
• D = There is positive evidence of risk
• X = Contraindicated
• N = Unknown

There are not sufficient studies in women to find out the risk to the baby when the mother takes this drug during breastfeeding. Consider the potential benefits and potential risks before taking this medication during breastfeeding.

Daunorubicin Drug Interactions

What medicines may interact with daunorubicin?

Although certain drugs should not be used together, in other cases two different drugs can be used together even if interactions are possible. In this case, your doctor may want to change the dose or take other precautions that may be needed. When you are using this medicine it is important that your doctor knows if you are currently taking any of the medicines that are listed below. The following interactions are selected on the basis of their potential significance and are not necessarily all inclusive.

Using this medication with any of the following medicines is not recommended. Your doctor may decide not to treat you with this drug or change some of the other medicines you use.

• Rotavirus Vaccine, Live

Using this medication with any of the following medicines is not usually recommended, but may be necessary in some cases. If the two drugs are prescribed together, your doctor may change the dose or adjust how often you use one or both drugs.

• Adenovirus Vaccine Type 4, Live
• Adenovirus Vaccine Type 7, Live
• Bacillus of Calmette and Guerin Vaccine, Live
• Cobicistat
• Influenza Virus Vaccine, Live
• Measles Virus Vaccine, Live
• Mumps Virus Vaccine, Live
• Rubella Virus Vaccine, Live
• Vaccine Smallpox
• Trastuzumab
• Typhoid Vaccine
• Varicella Virus Vaccine
• Yellow Fever Vaccine

Can food or alcohol interact with daunorubicin?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Daunorubicin?

The presence of other health problems in your body may affect the use of this drug. Some of the conditions that may interact with the drug duanorubicin are:

• Chicken pox
• Shingles (shingles)
• History of gout
• Kidney stones
• Heart disease
• any kind of infection
• Kidney illness
• Liver disease

Daunorubicin overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.