Dinoprostone: functions, dosage, side effects, how to use

What Drug Dinoprostone?

What is dinoprostone for?

Dinoprostone is a drug used to help prepare the cervix (the lower opening of the uterus) for labor. It is used in women who are experiencing normal pregnancies and who are at or near the due date of delivery. Dinoprostone is a natural substance your body uses to prepare for labor. This medicine relaxes and softens your cervix (cervical ripening) to allow the baby to pass through the birth canal during labor.

Dinoprostone dosage

How to use dinoprostone?

Dinoprostone is a drug that is inserted into the vagina near the cervix by a doctor or nurse. You will lie down while the medicine is being applied, and you will usually need to continue lying down for 2 hours after insertion. The health nurse will let you know when you can get up and take a walk.

Dinoprostone is a drug that should only be used in a hospital with a trained medical nurse. Your cervical changes will be continuously monitored, for signs of active labor (eg, water breaking, strong continuous contractions), and for your baby's condition. The health care professional will release the medication if there are side effects, after 12 hours, or when it is no longer needed. The effect of the drug wears off quickly after the drug is released.

How to store dinoprostone?

Dinoprostone is a drug that should be stored in the refrigerator. Don't freeze it. Other brands of this drug can have different storage rules. Pay attention to the storage instructions on the packaging of your product, or ask your pharmacist. Keep all medicines out of reach of children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product

Dinoprostone side effects

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dinoprostone dosage for adults?

For adults Childbirth Induction

Cervical Gel:A careful vaginal examination will reveal a degree of thinning that will regulate the size of the protected endocervical catheter to use. A 20 mm endocervical catheter should be used if there is no thinning, and a 10 mm catheter should be used if the cervix is ​​50% removed. Cervical dinoprostone gel should not be administered above the level of the internal os.

After administration of cervical dinoprostone gel, the patient should remain in the supine position for at least 15 to 30 minutes to minimize leakage from the cervical canal. If the desired response is obtained, the recommended interval before giving IV oxytocin is 6 to 12 hours.

If there is no cervical or uterine response to the initial dose of cervical gel, repeat doses may be given. The recommended repeated dose is 0.5 mg dinoprostone with a dosing interval of 6 hours. The need for additional doses and intervals should be determined by the attending physician based on the course of the clinical event. The maximum recommended cumulative dose for 24 hours is 1.5 mg of dinoprostone (7.5 mL Prepidil (R) Gel).

Vaginal Insert:

The dinoprostone dose in vaginal insert is 10 mg designed to be released at approximately 0.3 mg / hour for 12 hours. The dinoprostone for vaginal inserts should be removed at the start of active labor or 12 hours after insertion.

A vaginal dinoprostone insert is placed across the posterior vaginal fornix immediately after opening. When the drug is inserted into the vagina, it does not require sterile conditions. After admission, the patient must remain in a lying position for 2 hours afterward, but after that may walk. Care must be taken to ensure the vaginal insert remains in place if it is an outpatient basis.

After removing the dinoprostone vaginal insert, it is important to ensure that the slab has been removed.

Normal Adult Dose for Abortion

• Vaginal suppositories

Suppositories that use 20 mg of dinoprostone must be inserted into the vagina. The patient must remain in a sleeping position for 10 minutes after insertion.

Additional intravaginal administration of each subsequent suppository should be at intervals of 3 to 5 hours until the abortion occurs. In the timing of treatment, the intervals recommended above should be determined by the progress of the abortion, response to uterine contractility, and by the patient's tolerance. Continuous use of the drug for more than 2 days is not recommended.

What is the dose of dinoprostone for children?

Dinoprostone is a drug that does not have a fixed dosage for children. This medicine can be dangerous for children. It is important to understand the safety of drugs before use. Consult your doctor or pharmacist for more information.

In what dosage is dinoprostone available?

Dinoprostone is a drug that is available in dosages:

Gel, vaginal:Predipil: 0.5 mg / 3 g (3 g)

Insert, vagina:Cervidile: 10 mg

Suppositories, vaginal: Prostin E2: 20 mg

Dinoprostone Drug Warnings and Cautions

What side effects can be experienced due to dinoprostone?

Dinoprostone is a drug that can cause side effects. Side effects are rare and usually mild and include fever, nausea, vomiting, diarrhea or stomach pain.

Get emergency medical help if you have any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Tell your doctor right away if your contractions slow down or become inconsistent, or if you have:

• fever
• sudden vaginal bleeding
• coughing, wheezing, chest tightness, difficulty breathing
• pale skin, blue lips.

After the baby is born, get emergency medical attention if you have signs of excessive bleeding, such as:

• weakness or fainting
• unusual bleeding from your nose, mouth, vagina, or rectum
• bloody stools or, coughing up blood or vomiting that looks like coffee grounds
• sudden numbness or weakness, especially on one side of the body
• sudden, severe headache, confusion, problems with vision, sound, or balance
• unusual bruising, purple or red spots under your skin
• bleeding from the wound, surgical incision, or vein where the IV was inserted
• any bleeding that doesn't stop

Less serious side effects may include:

• nausea, stomach pain
• back pain
• a feeling of warmth in the vaginal area.

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Dinoprostone Drug Interactions

What should be known before using dinoprostone?

Dinoprostone is a drug that must be used under a doctor's supervision. Before using dinoprostone, tell your doctor and pharmacist if you are allergic to dinoprostone or any other medications.

Tell your doctor and pharmacist what prescription and nonprescription drugs you are taking, including vitamins.

Tell your doctor if you have or have ever had asthma. anemia; caesarean section or other uterine surgery; diabetes; high or low blood pressure; placenta previa; seizure disorders; six or more previous term pregnancies; glaucoma or increased pressure in the eye; cephalopelvic disproportion; difficult labor or previous trauma; unexplained vaginal bleeding; or heart, liver, or kidney disease.

Is dinoprostone safe for pregnant or breastfeeding women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category C according to the Food and Drug Administration in the United States (BPOM).

Following are references to pregnancy risk categories according to the Food and Drug Administration in the United States (BPOM):

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

There are not sufficient studies in women to find out the risk to the baby when the mother takes this drug during breastfeeding. Consider the potential benefits and potential risks before taking this medication during breastfeeding.

Dinoprostone overdose

What drugs may interact with dinoprostone?

Dinoprostone is a drug that can cause interactions. Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Does food or alcohol interact with dinoprostone?

Dinoprostone is certain drugs that should not be used while eating or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

• What health conditions can interact with dinoprostone?

The presence of other medical problems may affect the use of this drug. Make sure you tell your doctor if you have any other medical problems, especially:

• anemia (or history) - Dinoprostone, when used in doses that stimulate uterine contractions, can result in blood loss in some patients who may require blood transfusions
• asthma (or a history, including asthma in children)
• pulmonary disease - Dinoprostone can cause constriction of blood vessels in the lungs or narrowing of the lung passages, especially when used in doses that stimulate the uterus to contract
• epilepsy (or history) - although rare, seizures occur with dinoprostone when used in doses that stimulate the uterus to contract
• glaucoma - although rare, the pressure inside the eye has increased and pupil constriction has occurred during the use of medications such as dinoprostone; this may also be a problem with dinoprostone when used in doses that stimulate the uterus to contract
• heart or blood vessel disease (or history)
• high blood pressure (or history)
• low blood pressure (history) - Dinoprostone can cause changes in heart function or changes in blood pressure; two patients with a history of heart disease had heart attacks when dinoprostone was used in doses that stimulated the uterus to contract
• kidney disease (or history)
• liver disease (or history) - the body may not remove dinoprostone from the bloodstream at the usual rate, which may make dinoprostone work again or cause an increased chance of side effects, especially when dinoprostone is used in doses that stimulate the uterus to contract
• problems during childbirth
• uterine surgery (history)
• unusual vaginal bleeding - there is an increased risk of occurring with dinoprostone when used in doses that stimulate the uterus to contract

Overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.