Oseni: function, dosage, side effects, how to use it

Use

What is Oseni's medicine for?

Oseni is an oral diabetes medication that is given if lifestyle changes (diet and exercise programs) do not bring maximum results in controlling blood sugar levels in a person. Oseni is used for adult patients with type two diabetes. Patients with type one diabetes do not use Oseni as a treatment therapy.

Good blood sugar control can prevent you from kidney damage, blindness, nerve problems, loss of limbs, and problems with sexual function. Blood sugar that is well controlled will also lower your risk of heart attack or stroke.

Oseni consists of a combination of two drugs, namely allogliptin and pioglitazone. Pioglitazone contained in Oseni works by restoring the body's response to insulin. Meanwhile, allogliptin works by increasing the body's natural hormone called incretin.

Incretin is a natural hormone in the body that helps control blood sugar by increasing the release of insulin, especially after eating. Incretin also functions to reduce the amount of sugar produced by the liver.

What are the rules for drinking Oseni?

Oseni is a drinking drug that is taken by mouth. Take Oseni according to the dosage recommended by your doctor. Follow all directions on the packaging of your medicine.

Oseni is usually taken once a day with or without food. The manufacturer of this drug advises against splitting, crushing, or chewing the Oseni. However, several similar drugs (immediate-release tablet) can be split or crushed. Follow your doctor's directions for taking this medication.

The dosage given takes into account your health condition and your body's response to treatment. Use this remedy regularly to get the expected results. To make it easier for you to remember, take this drug at the same time every day.

How to save Oseni?

This medication is best stored at room temperature. Keep away from heat and direct light and damp places. Do not store this medication in the bathroom. When not in use, close the bottle of this medicine tightly. Read the storage instructions that are on the product package or follow the directions given by your pharmacist. Keep out of reach of children and pets.

Do not flush this medication down the toilet or drain unless instructed to do so. Discard this product when it has expired or is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the Oseni dosage for adult patients?

For patients who fail to control blood sugar with diet and exercise or metformin monotherapy

Initial dose: alogliptin-pioglitazone 25 mg / 15 mg or 25 mg / 30 mg once a day

For patients on allogliptin therapy who need additional blood sugar control

Initial dose: alogliptin-pioglitazone 25 mg / 15 mg or 25 mg / 30 mg once a day

For patients on pioglitazone therapy who require additional blood sugar control

Initial dose: alogliptin-pioglitazone 25 mg / 15 mg or 25 mg / 30 mg, or 25 mg / 45 mg, once daily

For patients with congestive heart failure conditions

Initial dose: alogliptin-pioglitazone 25 mg / 15 mg, once daily

For patients switching from two drugs (allogliptin and pioglitazone) to Oseni

Initial dose: use the same dose as the current medication

The titration dose is determined based on the glycemic response seen from HbA1C.

Maximum daily dose: allogliptin 25 mg; pioglitazone 45 mg

In what dosages and preparations is Oseni (alogliptin-pioglitazone) available?

Tablet, Oral: 12.5 mg / 15 mg; 12.5 mg / 30 mg; 12.5 mg / 45 mg; 25 mg / 15 mg; 25 mg / 30 mg; 25 mg / 45 mg

Side effects

What side effects may arise due to consumption of Oseni?

Call your doctor immediately when you notice symptoms of an allergic reaction due to consumption of Oseni, such as itching, shortness of breath, swelling of the face or throat and severe skin reactions (fever, sore throat, hot eyes, redness or purplishness that spreads and makes the skin peel off.

Remember that your doctor prescribes this medicine because the benefits outweigh the risk of possible side effects. The use of this drug in many people is known to not bring serious side effects.

Stop using Oseni and contact your doctor immediately if you notice symptoms of pancreatitis, such as nausea or vomiting, pain in the upper abdomen that radiates to the back.

Some of the side effects that may arise due to using Oseni are:

• Severe autoimmune reactions, such as itching, sores, cracked skin
• Joint pain that doesn't go away
• Red urine, burning sensation when urinating, irresistible urination
• Liver problems characterized by symptoms of upper abdominal pain, vomiting, fatigue, loss of appetite, concentrated urine, and jaundice
• Symptoms of heart failure, namely shortness of breath even when lying down, swelling in the legs, and rapid weight gain

The more common side effects that appear as side effects of Oseni are:

• Back pain
• Flu symptoms, such as nasal congestion, sinus pain, sore throat

Treatment with this medicine will affect your blood sugar levels. The risk of hypoglycemia or hyperglycemia can occur as one of the side effects that it carries. Recognize the symptoms of both, such as body shaking, sweating, blurred vision, tingling in the hands and feet for hypoglycemia and symptoms of hyperglycemia which include excessive thirst, increased urination frequency, flushed face, rapid breathing, and fruity breath.

The above list is not a complete list of the side effects produced by Oseni. Consult with your doctor about the possible side effects you are worried about will arise.

Warnings and Precautions

What should be considered before using Oseni?

• Tell your doctor about any drug allergies you have, including allogliptin or pioglitazone, along with other drugs.
• Before using this medicine, please inform your medical history including any diseases you have or are currently experiencing, such as bladder cancer, diabetes ketoacidosis, heart problems (heart failure or chest pain), kidney disease, liver problems, fluid in the lungs. lung, certain eye problems (macular edema, a condition in which the middle part of the retina, the macula, is swollen), pancreatitis, or gallstones.
• Tell me about all medicinal products that you are currently taking, including prescription, non-prescription drugs, vitamins, or other herbal medicines. Some drugs may interact so that it requires advice from a doctor when taking them
• You may experience blurred vision, dizziness, or drowsiness due to the drop in blood sugar that is too extreme or blood sugar that is too high. Do not engage in activities requiring high alertness after taking this medicine until you know its effect on your body
• Inform your doctor or dentist before undergoing a surgical procedure about using Oseni
• This medicine may increase the risk of fractures (usually in the upper arm, wrist, or leg, especially in women. Talk to your doctor about precautions you can take.
• Pioglitazone in Oseni is able to trigger ovulation even in women who have entered the premenopausal period and increase the chances of having an unplanned pregnancy. Tell your doctor if you have any birth control plans.
• Tell your doctor if you are planning to become pregnant or are pregnant and need blood sugar control. Your doctor may provide alternative treatments while you are pregnant

Is Oseni safe for pregnant and lactating women?

There is not sufficient information whether Oseni can pose a risk to the fetus, miscarriage, and cause birth defects. Breastfeeding a newborn to a mother who consumes Oseni may also be unsafe and risky. Breastfeeding is not recommended if the mother is using Oseni. Consult your doctor regarding the use of Oseni during pregnancy or breastfeeding.

Drug Interactions

What drugs might interact with Oseni?

Drug interactions may change how your medications work or increase your risk of serious side effects. The following are drugs that may cause interactions:

• Gemfibrozil
• Rifamycins (rifampin / rifabutin)

Tell your doctor about insulin use. Taking Oseni while on insulin can increase the risk of serious heart problems.

The above list does not include the entire list of drugs that may interact with Oseni. Keep a list of all the medications you take and keep your doctor informed, including prescription / nonprescription drugs, vitamins, and herbal remedies.

Overdose

What should I do in an emergency or overdose of Oseni?

Seek emergency medical help immediately by calling 119 or immediately to the nearest hospital emergency department if you overdose on Oseni. Symptoms of Oseni's overdose can include fainting or difficulty breathing.

What if I miss my medication schedule?

Take the missed dose as soon as you remember. If the time is too close to the next schedule, ignore the missed schedule and move on to the next schedule. Do not double your dose on a single medication schedule.