Prednisolone: ​​functions, dosage, side effects, how to use it

What Drug Prednisolone?

What is Prednisolone for?

Prednisolone is a drug with the function of treating conditions such as arthritis, blood problems, immune system disorders, skin and eye conditions, respiratory problems, cancer, and severe allergies. Prednisolone is a man-made drug that mimics a natural substance (corticosteroid hormone) made by the adrenal glands. This medicine reduces your immune system's response to various diseases to reduce symptoms of an allergic reaction such as pain and swelling.

The prednisolone dosage and side effects of prednisolone are detailed below.

How do I use Prednisolone?

Take this medication, with food or milk to prevent stomach upset, exactly as directed by your doctor. Carefully measure the dose using a special measuring device / spoon. Don't use a household spoon as you may not get the correct dose.

There are many brands, measures, and forms of liquid prednisolone available. Read the dosage instructions carefully for each product because the amount of prednisolone may differ between products. See also precautions and storage section.

Use the drug according to the dosage with caution. The dosage and length of treatment are based on your medical condition and response to treatment. Your doctor may direct you to take prednisolone 1-4 times a day or take a single dose every day. Mark your calendar with reminders to help you.

Do not stop taking this medication without consulting your doctor. Some conditions (such as seizures) can get worse when this drug is stopped. Your doctor will reduce the dose gradually.

If you have used prednisolone regularly for a long time or in high doses, you may experience symptoms if you stop taking this drug suddenly. To prevent these symptoms (such as weakness, weight loss, nausea, muscle pain, headache, fatigue, dizziness), the doctor may reduce the dose gradually. Consult your doctor or pharmacist for more details, and report any discontinuation reactions immediately. See also Warning section.

Tell your doctor if your condition does not improve or if it gets worse.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have any questions, consult your doctor or pharmacist.

How is Prednisolone stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Prednisolone dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the prednisolone dosage for adults?

Usual Adult Dose for Multiple Sclerosis

Tablets and syrup for acute exacerbations: 200 mg daily for one week followed by 80 mg daily for 1 month.

Usual Adult Dose for Branchopulmonary Dysplasia

Tablets and syrups for acute exacerbations: 200 mg daily for one week followed by 80 mg daily for 1 month.

Usual Adult Dose for Anti-Inflammatory

Sodium Phosphate:

Oral: 5-60 mg per day in divided doses 1-4 times / day.

Intravenous or intramuscular: 4-60 mg / day

For intraarticular, intralesional or fine tissue administration:

Large joints: 10 to 20 mg

Small joints: 4 to 5 mg

Bursae: 10 to 15 mg

Tendon sheath: 2-5 mg

Fine tissue infiltration: 10 to 30 mg

Ganglia: 5 to 10 mg

Injectable suspension (tebutate) for intraarticular, intralesional or fine tissue administration:

Large joints: 20 to 30 mg (doses> 40 mg not recommended)

Small joints: 8 to 10 mg

Bursae: 20 to 30 mg

Tendon sheath: 4-10 mg

Ganglia: 10 to 20 mg

Injectable suspension (acetate) for intraarticular, intralesional or soft tissue administration: 4-100 mg

Bursae: 10 to 15 mg

Tendon sheath: 2-5 mg

Fine tissue infiltration: 10 to 30 mg

What is the Prednisolone dosage for children?

Usual children's dose for immunosuppression

Oral: 0.1-2 mg / kg / day in divided doses 1-4 times a day.

Intravenous: 0.1-2 mg / kg / day in divided doses 1-4 times a day.

Usual children's dosage for asthma - acute

Oral: 1-2 mg / kg / day in divided doses 1-2 times a day for 3 to 5 days.

Intravenous: 2-4 mg / kg / day divided 3 or 4 times daily.

Usual children's dosage for Nephrotic Syndrome

First 3 episodes: Initial dose: 2 mg / kg / day (maximum dose 80 mg / day) until the urine is free of protein for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg / kg / dose daily for 4 weeks.

Regular use or long-term maintenance dose: 0.5-1 mg / kg / dose given daily for 3 to 6 months.

Usual children's dose for branchopulmonary dysplasia

2 mg / kg / day orally divided, twice daily for 5 days, followed by 1 mg / kg / day once daily for 3 days, followed by 1 mg / kg / daily dose for 3 doses.

In what dosage is Prednisolone available?

Suspension, oral: 15 mg / 5 mL

Prednisolone side effects

What side effects can be experienced due to Prednisolone?

Get emergency medical help if you have any of these signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, difficulty breathing, swelling of your face, lips, tongue, or throat, or feel like you might pass out.

Stop using Prednisolone and call your doctor if you have any of the following serious side effects:

• Problems with your eyesight;
• Swelling, rapid weight gain, feeling short of breath;
• Severe depression, unusual thoughts or behavior, seizures;
• Bloody stools or, coughing up blood;
• Pancreatitis (severe pain in the upper abdomen spreading to the back, nausea and vomiting, fast heartbeat);
• Low potassium (confusion, uneven heart rate, extreme thirst, increased urination, discomfort in the legs, muscle weakness or a feeling of weakness); or
• Dangerously high blood pressure (severe headache, blurred vision, ringing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeat, seizures)

Less serious side effects may include:

• Sleep problems (insomnia), mood changes;
• Acne, dry skin, thinning of the skin, bruising or discoloration of the skin;
• Slow wound healing;
• Sweating easily;
• Headache, dizziness, feeling spinning;
• Nausea, stomach pain, bloating; or
• Changes in the shape or location of body fat (especially in the arms, legs, face, neck, chest, and waist)

Not everyone experiences the following side effects. There may be some side effects not listed above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Prednisolone Drug Warnings and Cautions

What should be known before using Prednisolone?

In deciding to use a drug, the risks of taking the drug must be considered. It is up to you and your doctor. For this drug, the following should be considered:

Allergy

Tell your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read labels or ingredients carefully.

Children

The precise studies carried out to date have not demonstrated a specific pediatric problem that would limit the use of prednisolone in children. However, pediatric patients are more likely to have slow growth and bone problems if prednisolone is used for a long time. The recommended dosage should not be exceeded, and the patient should be monitored during therapy.

Elderly

The precise studies conducted to date have not shown specific problems in older people that may limit the usefulness of prednisolone in older people. However, elderly patients are more likely to have age-related kidney and bone problems, which may require adjusting the dose for patients receiving prednisolone.

Is Prednisolone safe for pregnant and lactating women?

There are not sufficient studies in women to find out the risk to the baby when the mother takes this drug during breastfeeding. Consider the potential benefits and potential risks before taking this medication during breastfeeding.

Studies in women show that this drug poses minimal risk to the baby when used during breastfeeding.

Prednisolone Drug Interactions

What medicines may interact with Prednisolone?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Using this medication with any of the following medicines is not recommended. Your doctor may decide not to give you this medicine or change some of the other drugs you take.

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Using this medication with any of the following medicines is not usually recommended, but may be necessary in some cases. If the two drugs are prescribed together, your doctor may change the dose or how often you use one or both drugs.

• Aldesleukin
• Aripiprazole
• Asparaginase
• Bupropion
• Carbamazepine
• Ceritinib
• Cobicistat
• Dabrafenib
• Daclatasvir
• Eliglustat
• Elvitegravir
• Eslicarbazepine Acetate
• Idelalisib
• Itraconazole
• Mitotane
• Nilotinib
• Piperaquine
• Pixantrone
• Ritonavir
• Siltuximab
• Sorafenib

Using this medication with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If the two drugs are prescribed together, your doctor may change the dose or how often you use one or both drugs.

• Alatrofloxacin
• Alcuronium
• Amobarbital
• Aspirin
• Atracurium
• Balofloxacin
• Cinoxacin
• Ciprofloxacin
• Clinafloxacin
• Desogestrel
• Dienogest
• Drospirenone
• Enoxacin
• Estradiol Cypionate
• Estradiol Valerate
• Ethinyl Estradiol
• Ethynodiol Diacetate
• Etonogestrel
• Fleroxacin
• Flumequine
• Fosphenytoin
• Gallamine
• Gemifloxacin
• Grepafloxacin
• Hexafluorenium
• Levofloxacin
• Levonorgestrel
• Licorice
• Lomefloxacin
• Medroxyprogesterone Acetate
• Mestranol
• Metocurine
• Moxifloxacin
• Norelgestromin
• Norethindrone
• Norfloxacin
• Norgestimate
• Norgestrel
• Ofloxacin
• Pefloxacin
• Phenytoin
• Primidone
• Prulifloxacin
• Rifampin
• Rosoxacin
• Rufloxacin
• Saiboku-To
• Sparfloxacin
• Temafloxacin
• Tosufloxacin
• Trovafloxacin Mesylate
• Vecuronium

Can food or alcohol interact with Prednisolone?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Prednisolone?

The presence of other health problems in your body may affect the use of this drug. Tell your doctor if you have other health problems.:

• Cataract or
• Congenital heart failure or
• Cushing's syndrome (adrenal gland problems) or
• Diabetes or
• Eye infection or
• Glaucoma or
• Hyperglycemia (high blood sugar) or
• Hypertension (high blood pressure) or
• Infections (for example, bacterial, viral, or fungal) or
• Mood changes, including depression or
• Myasthenia gravis (severe muscle weakness) or
• Osteoporosis (weak bones) or
• Peptic ulcer, active or a history of disease or
• Change in personality or
• Stomach or intestinal problems (eg, diverticulitis, ulcerative colitis) or
• Inactive tuberculosis - Use with caution. It might make things worse.
• Yeast infection or
• Herpes simplex eye infection - this drug cannot be used in patients with this condition.
• Kidney disease - Use with caution. The effect can be increased due to the slow cleansing of the drug from the body

Prednisolone overdose

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.