Ferric hydroxide sucrose complex: functions, dosage, side effects, how to use

What Drug Ferric Hydroxide Sucrose Complex?

What is the ferric hydroxide sucrose complex for?

This medicine is used to treat iron deficiency in the blood (anemia) in people with prolonged kidney disease, you may need extra iron because of blood loss during kidney dialysis. Your body also may need more iron if you are taking the drug erythropoietin to help make new red blood cells.

Iron is an essential part of red blood cells and is needed to transport oxygen in the body. Many patients with kidney disease cannot get enough iron from food and need injections.

How to use the ferric hydroxide sucrose complex?

This medicine is used to treat iron deficiency in the blood (anemia) in people with prolonged kidney disease. You may need extra iron due to blood loss during kidney dialysis. Your body also may need more iron if you are taking the drug erythropoietin to help make new red blood cells.

Iron is an essential part of red blood cells and is needed to transport oxygen in the body. Many patients with kidney disease cannot get enough iron from food and need injections.

How is the ferric hydroxide sucrose complex stored?

This medication is best stored at room temperature, away from direct light and damp places. Don't keep it in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product package or ask your pharmacist. Keep all medicines away from children and pets.

Do not flush medicines down the toilet or down the drain unless instructed to do so. Discard this product when it has expired or when it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dosage of Ferric Hydroxide Sucrose Complex

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dosage for ferric hydroxide sucrose complex for adults?

Normal Dosage for Adults with Iron Deficiency (Anemia)

Hemodialysis-dependent Chronic Kidney Disease (HDD-CKD):

5 mL (100 mg iron) pure slow IV for 2 to 5 minutes. Alternatively, 5 ml (100 mg iron) is diluted in a maximum of 100 mL 0.9% IV sodium chloride for at least 15 minutes. Repeat for successive hemodialysis sessions for a total cumulative dose of 1000 mg.

Dialysis Independent Chronic Kidney Disease (NDD-CKD):

10 mL (200 mg iron), pure, IV over 2 to 5 minutes is given on 5 different occasions over a 14-day period to achieve a total cumulative dose of 1000 mg over a 14-day period.

Alternatively, 25 mL (500 mg iron), diluted in a maximum of 250 mL 0.9% sodium chloride, IV over 210 to 240 minutes is given on day 1 and day 14 to give a cumulative dose of 1000 mg over a period of 14- day. However, there is limited experience with this dosage regimen. A clinical trial (n = 30) reported hypotension in 2 patients following administration of this dosing regimen.

Peritoneal Dialysis Dependent Chronic Kidney Disease (PDD-CKD):

Two infusions of 15 mL (300 mg elemental iron) each diluted in a maximum of 250 mL 0.9% sodium chloride are given IV over 90 minutes 14 days apart, followed by one infusion of 20 ml (400 mg elemental iron) diluted in maximum 250 mL of 0.9% sodium chloride given for 150 minutes 14 days after the second dose for a total cumulative dose of 1000 mg infusion over a period of 28 days.

What is the dosage for ferric hydroxide sucrose complex for children?

Treatment of Iron Treatment in Patients with CKD Dependent Hemodialysis

IV

Children ≥2 years: 0.5 mg / kg (not to exceed 100 mg per dose) every 2 weeks for 12 weeks; can be done by slow IV injection for 5 minutes or diluted in 25 ml 0.9% sodium chloride injection over 5-60 minutes.

Repeat treatment if necessary.

Treatment of iron medication in patients with CKD on ESA recipients independent of hemodialysis

IV

Children ≥2 years: 0.5 mg / kg (not to exceed 100 mg per dose) every 4 weeks for 12 weeks; can be done by slow IV injection for 5 minutes or diluted in 25 ml 0.9% sodium chloride injection over 5-60 minutes.

Repeat treatment if necessary.

Treatment of Iron Medication in Patients with CKD. ESA Recipient Dependent Peritoneal Dialysis

IV

Children ≥2 years: 0.5 mg / kg (not to exceed 100 mg per dose) every 4 weeks for 12 weeks; It can be done by slow IV injection for 5 minutes or diluted in 25 ml 0.9% sodium chloride injection over 5-60 minutes.

Repeat treatment if necessary.

In what dosage is the ferric hydroxide sucrose complex available?

Solution, intravenous: 20 mg / mL (2.5 mL, 5 mL, 10 mL)

Part 3: Side Effects

Ferric Hydroxide Sucrose Complex side effects

What side effects can be experienced due to the ferric hydroxide sucrose complex?

Common side effects include muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, swelling of the arms / legs, or pain, swelling, or redness at the injection area.

Get emergency medical help if you have any of the following signs of an allergic reaction: hives, hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have serious side effects such as:

• chest pain
• feeling like you might pass out
• swelling in your hands, ankles, or feet
• difficulty breathing; or
• high blood pressure (severe headache, blurred vision, ringing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeat, seizures).

Less serious side effects may include:

• muscle cramp
• weakness, tired feeling
• dizziness, anxiety, headache
• nausea, vomiting, stomach pain
• diarrhea, constipation
• earache
• sore throat, sinus pain, or stuffy nose
• decreased sense of taste
• joint pain
• pain, swelling, burning, or irritation around the IV needle.

Not everyone experiences this side effect. There may be some side effects not listed above. If you have any concerns about side effects, please consult a doctor or pharmacist.

Drug Warnings and Cautions Ferric Hydroxide Sucrose Complex

What should be known before using the ferric hydroxide sucrose complex?

Before receiving iron sucrose injection, tell your doctor and pharmacist if you are allergic to iron sucrose injection. other iron injections such as ferumoxytol (Feraheme), iron dextran (Dexferrum, Infed, Proferdex), or sodium ferrous gluconate (Ferrlecit); other drugs; or one of the ingredients in iron sucrose injection. Ask your pharmacist for a list of ingredients.

Tell your doctor and pharmacist what prescription and non-prescription drugs, vitamins, nutritional supplements, and herbal products you use or plan to use. Be sure to mention iron supplements taken by mouth. Your doctor may need to change the dose of your medication or monitor you carefully for side effects.
Tell your doctor if you have or have ever had certain medical conditions. Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. If you become pregnant while receiving iron sucrose injection treatment, call your doctor.

Is ferric hydroxide sucrose complex safe for pregnant and lactating women?

There are no adequate studies regarding the risks of using this drug in pregnant or breastfeeding women. Always consult your doctor to weigh the potential benefits and risks before using this medication. This drug is included in the risk of pregnancy category B according to the US Food and Drug Administration (FDA).

The following references the pregnancy risk categories according to the FDA:

• A = No risk,
• B = not at risk in several studies,
• C = May be risky,
• D = There is positive evidence of risk,
• X = Contraindicated,
• N = Unknown

Studies in women show that this drug poses only minimal risk to the baby when used during breastfeeding.

Drug Interactions of Ferric Hydroxide Sucrose Complex

What medicines may interact with ferric hydroxide sucrose complex?

Drug interactions can change the performance of your medications or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / non-prescription drugs and herbal products) and consult your doctor or pharmacist. Do not start, stop, or change the dose of any medication without your doctor's approval.

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Eltrombopag

Using this medication with some of the medicines below is not usually recommended, but in some cases it may be necessary. If both drugs are prescribed for you, your doctor will usually change the dosage or determine how often you should take them.

• Minocycline
• Mycophenolic Acid
• Zinc

Can food or alcohol interact with the ferric hydroxide sucrose complex?

Certain drugs should not be used with meals or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

Using this medication with any of the following may cause an increased risk of certain side effects, but they may not be avoided in some cases. When used together, your doctor may change the dose or how often you use these drugs, or give specific instructions about use of food, alcohol, or tobacco.

• foods containing phytic acid

What health conditions may interact with ferric hydroxide sucrose complex?

Any other health conditions you have can affect the use of this drug. Always tell your doctor if you have other health problems, especially:

• hypotension (low blood pressure) - use with caution. Can make this condition worse.
• iron overload - use is not recommended in patients with this condition

Overdosage of Ferric Hydroxide Sucrose Complex

What should I do in an emergency or overdose?

In case of an emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget a dose of this medicine, take it as soon as possible. However, when it is nearing the time of the next dose, skip the missed dose and return to the usual dosing schedule. Don't double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.